NOAEL Studies Cosmetic Ingredient

Dimethyl Sulphide NOAEL Studies

INCI: DIMETHYL SULPHIDE

CAS: 75-18-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 300 mg/kg bw/day rat oral 70 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 15 mg/kg bw/day rat oral 225 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =250 mg/kg bw/day Rat oral: feed 98 days subchronic EFSA AFC - 2009 - OutputID 2318 - no adverse effect observed at single/highest dose - Flavouring Group Evaluation 8 (FGE.08): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20 - doi:10.2903/j.efsa.2009.986
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOEL =250 mg/kg bw/day Rat - 98 days subchronic EFSA CEF - 2010 - OutputID 2042 - Scientific Opinion on Flavouring Group Evaluation 91 (FGE.91): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev1 (2009). EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) - doi:10.2903/j.efsa.2010.1337
INCHEM_WHO_jecfa_jecmono_v44jec09 46 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =250 mg/kg bw/day Rat - 14-week Toxicology study document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=fb2371703f2bfc41; raw_unit=mg/kg bw; context=A NOEL of 250 mg/kg bw N/R No safety sulfide per day was reported in concern a 14-week study in rats treated with methyl sulfide at multiple doses.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =1.4 mg/kg bw Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=19dd1c63d69daef1; raw_unit=mg/kg bw; context=A NOEL of 1.4 mg/kg bw per N/R No safety day was reported in a 90-day syudy concern in rats given 2-(methylthiomethyl)-3-phenyl-propenal (No.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =3.1 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=d244788b1031da46; raw_unit=mg/kg bw per day; context=A NOEL of 3.1 mg/kg bw per day N/R No safety dithiane was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.44 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=a29510e69acb7586; raw_unit=mg/kg bw per day; context=A NOEL of 0.44 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =9.2 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=85024a0d3f5195f8; raw_unit=mg/kg bw per day; context=A NOEL of 9.2 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =7 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=0cf9fb7375a297ae; raw_unit=mg/kg bw per day; context=A NOEL of 7 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.2 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=73a8cabd5a402b85; raw_unit=mg/kg bw per day; context=A NOEL of 0.2 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.56 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=19c489ae12152e8b; raw_unit=mg/kg bw per day; context=A NOEL of 0.56 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with cyclopentanethiol (No.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.06 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=72a586b88360d9d3; raw_unit=mg/kg bw per day; context=A NOEL of 0.06 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.52 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=bddabac45dc4e79e; raw_unit=mg/kg bw per day; context=A NOEL of 0.52 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.43 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=6083c840e2727c0d; raw_unit=mg/kg bw per day; context=A NOEL of 0.43 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =3.4 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=9c509e4f83a464ef; raw_unit=mg/kg bw per day; context=A NOEL of 3.4 mg/kg bw per day N/R No safety was reported in a 90-day study in concern rats treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =1.9 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=fc01cae697d6aac0; raw_unit=mg/kg bw per day; context=A NOEL of 1.9 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern given this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =2.8 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=a4e4f374ecaf7bad; raw_unit=mg/kg bw per day; context=A NOEL of 2.8 mg/kg bw per day N/R No safety alpha-methyl-beta-mercaptopropyl was reported in a 90-day study in rats concern sulfide given this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.7 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=614fa8b189602c37; raw_unit=mg/kg bw per day; context=A NOEL of 0.7 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern given this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =7.3 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=b4dd2eaed843d16c; raw_unit=mg/kg bw per day; context=A NOEL of 7.3 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with propyl disulfide (No.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =4.6 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=aae47f620c4cde7a; raw_unit=mg/kg bw per day; context=A NOEL of 4.6 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with diallyl trisulfide (No.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.23 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=f9e06793b0658fb2; raw_unit=mg/kg bw per day; context=A NOEL of 0.23 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =1.2 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=105735887671f2d0; raw_unit=mg/kg bw per day; context=A NOEL of 1.2 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =4.8 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=f5a6e32481039156; raw_unit=mg/kg bw per day; context=A NOEL of 4.8 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with dipropyl trisulfide (No.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =6.5 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=a563eac5a47eb539; raw_unit=mg/kg bw per day; context=A NOEL of 6.5 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with ethyl thioacetate (No.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =1000 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=327f962c90548d9c; raw_unit=mg/kg bw per day; context=483) only at that dose, and a NOEL of 1000 mg/kg bw per day was reported in a 90-day study in rats treated with methyl thio-butyrate (No.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =3000 mg/kg bw/day Human; Rat; Dog; Monkey - 87 weeks Toxicology study document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=3380cd7e7b733379; raw_unit=mg/kg bw per day; context=A NOEL of 3000 mg/kg bw per day N/R No safety was reported in monkeys given this concern substance at multiple doses for 74-87 weeks; similar results in rats, dogs, and humans.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =250 mg/kg bw/day Rat - 14-week Toxicology study document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=fb2371703f2bfc41; raw_unit=mg/kg bw; context=A NOEL of 250 mg/kg bw N/R No safety sulfide per day was reported in concern a 14-week study in rats treated with methyl sulfide at multiple doses.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =1.4 mg/kg bw Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=19dd1c63d69daef1; raw_unit=mg/kg bw; context=A NOEL of 1.4 mg/kg bw per N/R No safety day was reported in a 90-day syudy concern in rats given 2-(methylthiomethyl)-3-phenyl-propenal (No.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =3.1 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=d244788b1031da46; raw_unit=mg/kg bw per day; context=A NOEL of 3.1 mg/kg bw per day N/R No safety dithiane was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.44 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=a29510e69acb7586; raw_unit=mg/kg bw per day; context=A NOEL of 0.44 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =9.2 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=85024a0d3f5195f8; raw_unit=mg/kg bw per day; context=A NOEL of 9.2 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =7 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=0cf9fb7375a297ae; raw_unit=mg/kg bw per day; context=A NOEL of 7 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.2 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=73a8cabd5a402b85; raw_unit=mg/kg bw per day; context=A NOEL of 0.2 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.56 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=19c489ae12152e8b; raw_unit=mg/kg bw per day; context=A NOEL of 0.56 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with cyclopentanethiol (No.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.06 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=72a586b88360d9d3; raw_unit=mg/kg bw per day; context=A NOEL of 0.06 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.52 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=bddabac45dc4e79e; raw_unit=mg/kg bw per day; context=A NOEL of 0.52 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.43 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=6083c840e2727c0d; raw_unit=mg/kg bw per day; context=A NOEL of 0.43 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =3.4 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=9c509e4f83a464ef; raw_unit=mg/kg bw per day; context=A NOEL of 3.4 mg/kg bw per day N/R No safety was reported in a 90-day study in concern rats treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =1.9 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=fc01cae697d6aac0; raw_unit=mg/kg bw per day; context=A NOEL of 1.9 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern given this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =2.8 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=a4e4f374ecaf7bad; raw_unit=mg/kg bw per day; context=A NOEL of 2.8 mg/kg bw per day N/R No safety alpha-methyl-beta-mercaptopropyl was reported in a 90-day study in rats concern sulfide given this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.7 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=614fa8b189602c37; raw_unit=mg/kg bw per day; context=A NOEL of 0.7 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern given this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =7.3 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=b4dd2eaed843d16c; raw_unit=mg/kg bw per day; context=A NOEL of 7.3 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with propyl disulfide (No.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =4.6 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=aae47f620c4cde7a; raw_unit=mg/kg bw per day; context=A NOEL of 4.6 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with diallyl trisulfide (No.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =0.23 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=f9e06793b0658fb2; raw_unit=mg/kg bw per day; context=A NOEL of 0.23 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =1.2 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=105735887671f2d0; raw_unit=mg/kg bw per day; context=A NOEL of 1.2 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with this substance only at that dose.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =4.8 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=f5a6e32481039156; raw_unit=mg/kg bw per day; context=A NOEL of 4.8 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with dipropyl trisulfide (No.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =6.5 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=a563eac5a47eb539; raw_unit=mg/kg bw per day; context=A NOEL of 6.5 mg/kg bw per day N/R No safety was reported in a 90-day study in rats concern treated with ethyl thioacetate (No.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =1000 mg/kg bw/day Rat - 90-day Subchronic toxicity document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=327f962c90548d9c; raw_unit=mg/kg bw per day; context=483) only at that dose, and a NOEL of 1000 mg/kg bw per day was reported in a 90-day study in rats treated with methyl thio-butyrate (No.
INCHEM_WHO_jecfa_jecmono_v44jec09 NOEL =3000 mg/kg bw/day Human; Rat; Dog; Monkey - 87 weeks Toxicology study document_id=jecfa_jecmono_v44jec09; title=973. Simple aliphatic and aromatic sulfides and thiols (WHO Food Additives Series 44); path=mirror/documents/jecfa/jecmono/v44jec09.htm; row_hash=3380cd7e7b733379; raw_unit=mg/kg bw per day; context=A NOEL of 3000 mg/kg bw per day N/R No safety was reported in monkeys given this concern substance at multiple doses for 74-87 weeks; similar results in rats, dogs, and humans.
NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 102.2158 mg/L - Inhalation - In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5120; Record_ID=acute_inhalation_987; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9026398; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=102.2158; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026398
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =3300 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10018; row=15678; data_type=In Vivo; mixture=Chemical; chemical_name=Dimethyl sulfide; preferred_name=Dimethyl sulfide; dtxsid=DTXSID9026398; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026398; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10030; Record_ID=skin_sensitization_invivo_2218; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026398; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026398
NTP_ICE_skin_sensitization Induction dose per skin area 675 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10028; Record_ID=skin_sensitization_invivo_2218; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026398; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=675; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026398
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10034; Record_ID=skin_sensitization_invivo_2218; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9026398; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026398
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =55904.6 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=DOE Protective Action Criteria:15514739:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cd2813ba231d286578f6cc60d64ebecc
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >=250 mg/kg bw/day Rat oral chronic; 14 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8ce4b0a7c65d1c9c82; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10176/7/6/2?documentUUID=cc7d04d9-200a-40c1-8438-643521c1195d; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15835308:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6faeb6d0a2b86552d6f064b47b9432d2
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =250 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA CEF (2011). Scientific Opinion on Flavouring Group Evaluation 91, Revision 1 (FGE.91Rev1): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev3 (2011). EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF). doi:10.2903/j.efsa.2011.2459.; TITLE=Scientific Opinion on Flavouring Group Evaluation 91, Revision 1 (FGE.91Rev1): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev3 (2011). EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2011.2459; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=EFSA:15621437:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fe101dc7f8b0f9a0bce8cd791582ec38
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =12.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631480:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_034e5ae3f3b64e6b8e858d7ba02b3b09
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier QS3J7O7L3U UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"QS3J7O7L3U"}
openFDA substances FDA UNII substance identifier QS3J7O7L3U UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"QS3J7O7L3U"}
openFDA substances FDA UNII substance identifier QS3J7O7L3U UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"QS3J7O7L3U"}
openFDA substances FDA UNII substance identifier QS3J7O7L3U UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"QS3J7O7L3U"}