Is Diisobutyl Adipate safe in cosmetics?
Diisobutyl Adipate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Diisobutyl Adipate
Also known as: 4-02-00-01962, BRN 1791084, EINECS 205-450-3, UNII-8OPY05ZY7S
INCI: DIISOBUTYL ADIPATE
Diisobutyl Adipate (CAS 141-04-8) is a cosmetic cosmetic ingredient functioning as Emollient / skin conditioning agent; also evaluated as a food-grade flavouring. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 141-04-8 →
Auto-generated CPSR Part A draft with source citations
Function
Emollient / skin conditioning agent; also evaluated as a food-grade flavouring agent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
bis(2-methylpropyl) hexanedioate
InChIKey
RDOFJDLLWVCMRU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — JECFA evaluation: no safety concern at current levels of intake (2010)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diisobutyl Adipate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diisobutyl Adipate across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 13500 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1967
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
DIISOBUTYL ADIPATE | 2010 | No safety concern at current levels of intake when used as a flavouring agent | TRS 960-JECFA 73/71
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Plasticizer
Processing aids not otherwise specified
Softener and conditioner
Solvent
Regulatory List Membership (5)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
FDA Indirect Food Contact Additives
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Diisobutyl Adipate.
Regulatory Flags
endocrine_disruptor
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
4-02-00-01962
BRN 1791084
EINECS 205-450-3
UNII-8OPY05ZY7S
Chemical Function
Solvent
Softener and conditioner
Plasticizer
Deodorizer
Fragrance
Regulatory Lists
detected; Europe; Toys and children's products
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
consumer_product
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184260
Frequently Asked Questions
Is Diisobutyl Adipate allowed in the EU?
Diisobutyl Adipate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diisobutyl Adipate do in cosmetics?
Diisobutyl Adipate functions as: Emollient / skin conditioning agent; also evaluated as a food-grade flavouring agent. It is classified as a cosmetic ingredient in our database. CAS number: 141-04-8.
Is Diisobutyl Adipate used outside cosmetics?
Diisobutyl Adipate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diisobutyl Adipate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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