NOAEL Studies Cosmetic Ingredient

DIHYDRO PENTAMETHYLINDANONE NOAEL Studies

CAS: 33704-61-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2901 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_5713; row=14499; data_type=In Vivo; mixture=Chemical; chemical_name=Dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone; preferred_name=Cashmeran; dtxsid=DTXSID8047399; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8047399; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =10 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1ee4b0a7c65d1c7966; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15957/7/6/2?documentUUID=1af2f395-5c67-4f0b-b69b-ef8e8df74d31; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15831928:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1786ddb60857c5bd1bf9ecdcd1b50e3c
ToxValDB_ECHA_IUCLID NOAEL >=107 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8f6e4b0a7c65d21ad4a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/15957?documentUUID=b4a66925-42e5-469e-a4ca-44fc371068cd; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15855445:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_db76de2f3e76a7fb2b9f21aea40332a8
ToxValDB_ECHA_IUCLID NOAEL =150 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b8162; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15957/7/9/2?documentUUID=1af2f395-5c67-4f0b-b69b-ef8e8df74d31; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=P0: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID:15855483:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cffb8eeb3ccfe991e266d6bdbb8d2561
ToxValDB_ECHA_IUCLID NOAEL >=110 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8f6e4b0a7c65d21ad4a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/15957?documentUUID=b4a66925-42e5-469e-a4ca-44fc371068cd; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15856258:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_df8d6419e9a342d3411a3c5e762bcf1f
ToxValDB_ECHA_IUCLID NOAEL =1875 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b8162; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15957/7/9/2?documentUUID=1af2f395-5c67-4f0b-b69b-ef8e8df74d31; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15856297:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_770408bfcab9d55d70d26416ca8902b1
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =1.47 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632490:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ff550a24ec8917bce0089e6617b83e5a
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier BZR4438MY4 UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H22O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BZR4438MY4"}
openFDA substances FDA UNII substance identifier BZR4438MY4 UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H22O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BZR4438MY4"}
openFDA substances FDA UNII substance identifier BZR4438MY4 UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H22O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BZR4438MY4"}
openFDA substances FDA UNII substance identifier BZR4438MY4 UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H22O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BZR4438MY4"}