Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate (CAS 130905-60-1) is a cosmetic cosmetic ingredient functioning as Emollient, skin conditioning agent (complex mixed diglyceryl ester). NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
US NotesPermitted — not listed in 21 CFR 700; CIR reviewed glyceryl monoesters as a class and found them safe
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Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate.
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Toxicological Studies
1 study endpoint found for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=1800 mg/kg bw/day
oral
Rat
short-term
ToxValDB_ECHA_IUCLID
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate across SCCS product categories, with measured dermal absorption where available.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate.
Public NOAEL study rows linked to Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate by CAS number or substance name.
Studies
1
Lowest NOAEL
1800 mg/kg bw/day
Highest NOAEL
1800 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Chemical Function
Softener and conditioner
Australian Status
AICIS status:listed
Frequently Asked Questions
Is Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate safe in cosmetics?
Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Is Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate allowed in the EU?
Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate do in cosmetics?
Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate functions as: Emollient, skin conditioning agent (complex mixed diglyceryl ester). It is classified as a cosmetic ingredient in our database. CAS number: 130905-60-1.
What is the NOAEL for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate?
The NOAEL (No Observed Adverse Effect Level) for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate is =1800 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Compliance Tools
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