Good Cosmetic Ingredient NOAEL Data

Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate

INCI: DIGLYCERYL ADIPATE/CAPRATE/CAPRYLATE/HYDROXYSTEARATE/ISOSTEARATE/STEARATE

Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate (CAS 130905-60-1) is a cosmetic cosmetic ingredient functioning as Emollient, skin conditioning agent (complex mixed diglyceryl ester). NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.

View industrial chemical safety profile for CAS 130905-60-1 →

Auto-generated CPSR Part A draft with source citations
Function
Emollient, skin conditioning agent (complex mixed diglyceryl ester)
Safety Rating
GOOD

Regulatory Status

EU EU Status permitted
US US Status permitted
US Notes Permitted — not listed in 21 CFR 700; CIR reviewed glyceryl monoesters as a class and found them safe

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =1800 mg/kg bw/day oral Rat short-term ToxValDB_ECHA_IUCLID

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate across SCCS product categories, with measured dermal absorption where available.

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Softener and conditioner

Expert Verdict

Expert safety assessment and concern-level summary for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate.

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate by CAS number or substance name.

Studies
1
Lowest NOAEL
1800 mg/kg bw/day
Highest NOAEL
1800 mg/kg bw/day
ToxValDB_ECHA_IUCLID

Chemical Function

Softener and conditioner

Australian Status

AICIS status: listed

Frequently Asked Questions

Is Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate safe in cosmetics?

Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.

Is Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate allowed in the EU?

Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate do in cosmetics?

Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate functions as: Emollient, skin conditioning agent (complex mixed diglyceryl ester). It is classified as a cosmetic ingredient in our database. CAS number: 130905-60-1.

What is the NOAEL for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate?

The NOAEL (No Observed Adverse Effect Level) for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate is =1800 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.

Related Ingredients

Acacia Decurrens/Jojoba/Sunflower Seed Wax Polyglyceryl-3 Esters
Excellent Same category
Skin conditioning emollient, texturizer
Acetic/Linoleic/Palmitic Triglyceride
Excellent Same category
Skin conditioning (emollient)
Acetyl Ornithine
Excellent Same category
Emollient
Acetyl Proline
Excellent Same category
Emollient
Acetyl Triethylhexyl Citrate
Excellent Same category
Emollient, Film Forming, Plasticiser
Acetyl Trihexyl Citrate
Excellent Same category
Plasticiser, Skin Conditioning (Emoll...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good Similar safety
Antioxidant
(ARCTIUM LAPPA/CARROT/COLOCASIA ESCULENTA/DIOSCOREA BATATAS/GARLIC/GINGER/IPOMOEA BATATAS/NELUMBO NUCIFERA/ONION/POTATO BULBS)/(CHESTNUT/CITRUS UNSHIU/EGGPLANT/FIG/GRAPE/KIWI/LYCOPERSICON ESCULENTUM/MALUS PUMILA/MUME/PEACH/PLUM/PUMPKIN/PYRUS SEROTINA/RADISH/ZIZIPHUS JUJUBA FRUIT)/(ALLIUM TUBEROSUM/ALOE BARBADENSIS/ANGELICA UTILIS/BRASSICA OLERACEA ACEPHALA/CABBAGE/CELERY/SACCHARINA JAPONICA/UNDARIA PINNATIFIDA LEAF)/(ALLIUM FISTULOSUM/ENTEROMORPHA COMPRESSA/OENANTHE JAVANICA STALK)/LENTINULA EDODES/SUCROSE FERMENT FILTRATE
Good Similar safety
Humectant, Skin Conditioning - Humect...
DIHYDRO PENTAMETHYLINDANONE
Good Browse nearby
Fragrance, Perfuming
DIHYDROGENATED TALLOW HYDROXYETHYLMONIUM METHOSULFATE
Good Browse nearby
Antistatic, Hair Conditioning
DIHYDROMYRICETIN
Good Browse nearby
Skin Conditioning

Is Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Diglyceryl Adipate/Caprate/Caprylate/Hydroxystearate/Isostearate/Stearate in your formulation.