Is Diethylhexyl Syringylidenemalonate safe in cosmetics?
Diethylhexyl Syringylidenemalonate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Diethylhexyl Syringylidenemalonate
Also known as: 1,3-bis(2-ethylhexyl) 2-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]propanedioate, Oxynex ST
INCI: DIETHYLHEXYL SYRINGYLIDENEMALONATE
Diethylhexyl Syringylidenemalonate (CAS 444811-29-4) is a cosmetic antioxidant functioning as Skin Protecting, Photostabilizer, Antioxidant. Reported NOAEL =200 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 444811-29-4 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Protecting, Photostabilizer, Antioxidant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
bis(2-ethylhexyl) 2-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]propanedioate
InChIKey
NSBAXYINVVKQQI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not an approved sunscreen active; used as cosmetic ingredient (stabilizer/antioxidant)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethylhexyl Syringylidenemalonate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Diethylhexyl Syringylidenemalonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =200 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Safe; antioxidant", "source": "dermatology literature"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Expert Verdict
Expert safety assessment and concern-level summary for Diethylhexyl Syringylidenemalonate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Diethylhexyl Syringylidenemalonate by CAS number or substance name.
Studies
1
Lowest NOAEL
200 mg/kg bw/day
Highest NOAEL
200 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
1,3-bis(2-ethylhexyl) 2-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]propanedioate
Oxynex ST
Chemical Function
Humectant
Frequently Asked Questions
Is Diethylhexyl Syringylidenemalonate allowed in the EU?
Diethylhexyl Syringylidenemalonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethylhexyl Syringylidenemalonate do in cosmetics?
Diethylhexyl Syringylidenemalonate functions as: Skin Protecting, Photostabilizer, Antioxidant. It is classified as a Antioxidant in our database. CAS number: 444811-29-4.
What is the NOAEL for Diethylhexyl Syringylidenemalonate?
The NOAEL (No Observed Adverse Effect Level) for Diethylhexyl Syringylidenemalonate is =200 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Diethylhexyl Syringylidenemalonate used outside cosmetics?
Diethylhexyl Syringylidenemalonate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diethylhexyl Syringylidenemalonate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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