Good Cosmetic Ingredient GHS Classified

Diethyl Succinate

Also known as: Butanedioic acid, diethyl ester, 4-02-00-01914, BRN 0907645, Diethyl ethanedicarboxylate, EINECS 204-612-0 (+3 more)

INCI: DIETHYL SUCCINATE

Diethyl Succinate (CAS 123-25-1) is a cosmetic cosmetic ingredient functioning as Fragrance, Plasticizer, Emollient, Solvent. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 123-25-1 →

Auto-generated CPSR Part A draft with source citations

CAS Number

123-25-1

View industrial chemical safety profile →

Function

Fragrance, Plasticizer, Emollient, Solvent

Safety Rating

GOOD

Chemistry & Identifiers

Formula

C8H14O4

174.19 g/mol

EC Number

204-612-0

PubChem CID

31249

IUPAC Name

diethyl butanedioate

InChIKey

DKMROQRQHGEIOW-UHFFFAOYSA-N

ChEBI: CHEBI:169507 UNII: ELP55C13DR Wikidata: Q1978959

Regulatory Status

EU EU Status permitted

US US Status permitted

US Notes CIR Expert Panel (2010/2012 Final Report) concluded safe in present practices of use and concentration as part of a 56-ingredient dicarboxylic acid group assessment. Holds FEMA GRAS No. 2377 for food flavoring.

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Diethyl Succinate.

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects

The substance is mildly irritating to the eyes.

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Diethyl Succinate across SCCS product categories, with measured dermal absorption where available.

HRIPT Human Patch Test Studies

1 human repeat insult patch test aggregated from dermatological literature.

Test Type	N	Sensitized	Dose µg/cm²	NESIL µg/cm²	Potency
HMT	-	0	2700	-	-

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

100 - 1,000 tonnes

Substance Type

SUBSTANCE

SVHC Candidate

Additional Ingredient Properties

1 property record from structured ingredient metadata.

ecotoxicity

{"biodegradable": "yes", "biodegradation_days": "28-60", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "low aquatic toxicity", "freshwater_toxicity": "minimal impact", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "no", "pa…

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (1)

ICSC Safety Card

1079

Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Regulatory (5)

JECFA Number

617