NOAEL Studies
Cosmetic Ingredient
Diethyl Carbonate NOAEL Studies
INCI: DIETHYL CARBONATE
CAS: 105-58-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_inhalation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | >1.268 | mg/L | - | Inhalation | Duration=7 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2044; Record_ID=acute_inhalation_582; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3025041; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=1.268; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14116/7/3/3/?documentUUID=0d83214e-2383-41dc-80d2-f360bf2a03fc; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3025041; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3025041 |
| NTP_ICE_acute_inhalation | LC50 | >1.83 | mg/L | - | Inhalation | Duration=7 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2046; Record_ID=acute_inhalation_584; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3025041; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=1.83; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14116/7/3/3/?documentUUID=0d83214e-2383-41dc-80d2-f360bf2a03fc; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3025041; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3025041 |
| NTP_ICE_acute_inhalation | LC50 | >17.75 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2047; Record_ID=acute_inhalation_586; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3025041; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=17.75; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/3/3/?documentUUID=8f75bd1f-0764-4ff3-99be-7e207dc6b3c3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3025041; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3025041 |
ToxValDB_ECHA_IUCLID 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =252 | mg/kg bw/day | Mouse | oral | chronic; 83 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c0a1d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/6/2?documentUUID=cdf3ec07-71e1-43a6-9f4c-2a96e2844604; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15845098_15850283:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_571abfbc47f6dbcde74046e0a21908a1 |
| ToxValDB_ECHA_IUCLID | LEL | =19500 | mg/m3 | Rat | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/3/3?documentUUID=cdf3ec07-71e1-43a6-9f4c-2a96e2844604; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15797949_15799164:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2ab446e17c3656da121a2e401137b27c |
| ToxValDB_ECHA_IUCLID | LOAEL | =12.6 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2caa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/8?documentUUID=cdf3ec07-71e1-43a6-9f4c-2a96e2844604; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15820279:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3054d755c0313c698c9fd4a92a059d68 |
| ToxValDB_ECHA_IUCLID | LOAEL | =35.7 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/9/3?documentUUID=cdf3ec07-71e1-43a6-9f4c-2a96e2844604; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15823936:F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_de81f7adeb86c0d6415a624c0534f50a |
| ToxValDB_ECHA_IUCLID | NOAEC | >=1593 | mg/m3 | Rat | inhalation | acute; 7 hours | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/6/3?documentUUID=a7f8d8fe-b14c-491d-a395-65e07f47b237; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15828464:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c1c2629f237e2c9b29ee0939e024bff2 |
| ToxValDB_ECHA_IUCLID | NOAEC | =18995 | mg/m3 | Rat | inhalation | acute; 7 hours | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/6/3?documentUUID=a7f8d8fe-b14c-491d-a395-65e07f47b237; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827697_15828485:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_85c9f3b868a79c18b639e62e1c11d986 |
| ToxValDB_ECHA_IUCLID | NOAEC | =20971 | mg/m3 | Rat | inhalation | acute; 7 hours | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/6/3?documentUUID=a7f8d8fe-b14c-491d-a395-65e07f47b237; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827697_15828485:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8ff3ae1642a31635988a51cc0b5b25b2 |
| ToxValDB_ECHA_IUCLID | NOAEL | =10.7 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b55a3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/9/2?documentUUID=cdf3ec07-71e1-43a6-9f4c-2a96e2844604; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=F2:; STUDY_GROUP=ECHA IUCLID:15862492:F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6445f12bb9d346953055567e5c775e15 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=130 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b55a3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/9/2?documentUUID=cdf3ec07-71e1-43a6-9f4c-2a96e2844604; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15862491:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_20fa39b2e83d9a86a60d111d7fa39a00 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~140 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2ca8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/8?documentUUID=a7f8d8fe-b14c-491d-a395-65e07f47b237; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15820278:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2660f88b40c63c272835609530292a99 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=214.3 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3bd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/9/3?documentUUID=cdf3ec07-71e1-43a6-9f4c-2a96e2844604; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821938_15823940:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_777cd6533034bb0fc8f802933c1a6f1e |
| ToxValDB_ECHA_IUCLID | NOAEL | =300 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2ca6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/8?documentUUID=a7f8d8fe-b14c-491d-a395-65e07f47b237; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15820277:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cf7fe54809eb56c423753cfdbbe42a3f |
| ToxValDB_ECHA_IUCLID | NOAEL | >=956 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/9/3?documentUUID=cdf3ec07-71e1-43a6-9f4c-2a96e2844604; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15823939:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3347de20bbd7a7f74b5a7f4632629e13 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3c1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7106/7/9/3?documentUUID=cdf3ec07-71e1-43a6-9f4c-2a96e2844604; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15823937:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_36bf5ab127e305545b3d7c91d9344c67 |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =17.6 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631173_15631174:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b6cf11d425c0bfc57ddc6d8bf2ab4fbf |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =69.792 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631173_15631174:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_533b24e4fa6fe5b9ff4231ca33bbf2f1 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 3UA92692HG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H10O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3UA92692HG"} |
| openFDA substances | FDA UNII substance identifier | 3UA92692HG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H10O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3UA92692HG"} |
| openFDA substances | FDA UNII substance identifier | 3UA92692HG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H10O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3UA92692HG"} |
| openFDA substances | FDA UNII substance identifier | 3UA92692HG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H10O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3UA92692HG"} |