NOAEL Studies
Cosmetic Ingredient
Diethanolamine (DEA) NOAEL Studies
INCI: DIETHANOLAMINE
CAS: 111-42-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR_vision_codex 36 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR_vision_codex | NOAEL | =250 | mg/kg | rat | - | 5 d | NOAEL study | {"citation":"250; 500; 99","dose":", 250, and 500 mg/kg bw/d diethanolamine (purity >99%) in 95% ethanol were applied to the backs of 10 male and 10 female F344/N rats, 5 d/wk for 13 weeks.35 Vehicle only was applied to the negative control group.","effect":", 250, and 500 mg/kg bw/d diethanolamine (purity >99%) in 95% ethanol were applied to the backs of 10 male and 10 female F344/N rats, 5 d/wk for 13 weeks.35 Vehicle only was applied to the negative control group. (The square area of the dose site was not provided.) One male and 2 females given 500 mg/kg died or were killed in moribund condition during the study. Clinical signs of toxicity, observed in males and females given 125 to 500 mg/kg diethanolamine, were irritation and crusting at the application site. The no observable adverse effect level (NOAEL) for ulceration was 125 mg/kg for male rats and 63 mg/kg for female rats. Final mean bws were statistically sig- nificantly decreased in males dosed with 250 and 500 mg/kg and females dosed with 125 to 500 mg/kg diethanolamine. Increases in absolute and relative kidney weights were observed with increased incidence of renal lesions. Nephropa- thy was observed in lower and mid-dose females, but a clear treatment effect was not seen in males. Increases in absolute and relative liver weights were not accompanied by an increase in he...","page":11,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_001"} |
| CIR_vision_codex | NOAEL | =250 | mg/kg d | rat | oral | 7 weeks | oral toxicity | {"citation":"125; 500; (7","dose":"ed with 125 to 500 mg/kg diethanolamine.","effect":"ed with 125 to 500 mg/kg diethanolamine. Increases in absolute and relative kidney weights were observed with increased incidence of renal lesions. Nephropa- thy was observed in lower and mid-dose females, but a clear treatment effect was not seen in males. Increases in absolute and relative liver weights were not accompanied by an increase in hepatic lesions. Demyelination in the medulla oblongata was seen in all high-dose animals (7 females) given 250 mg/kg diethanolamine; this lesion was minimal in severity. An NOAEL was not achieved regarding hematological changes, but the researchers did note that the differences between con- trols and male rats exposed to 32 mg/kg diethanolamine were minimal. Oral. A previous safety assessment of triethanolamine, dietha- nolamine, and monoethanolamine reported on oral studies con- ducted in which neonatal rats were dosed with 1 to 3 mM/kg/d diethanolamine, as a neutralized salt, on days 5 to 15 after birth, male rats were dosed with 4 mg/mL neutralized diethanolamine in drinking water for 7 weeks, and rats were fed 0 to 0.68 g/kg/d diethanol...","page":11,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_002"} |
| CIR_vision_codex | NOAEL | =1.5 | mg/m3 | rat | inhalation | 3 months | repeated dose toxicity | {"citation":"0, 1; 5, 3; 8","dose":"et concentrations of 0, 1.5, 3, and 8 mg/m3 diethanolamine using the same dosing schedule as above, and recovery groups of 10 females were exposed to 3 or 8 mg/m3, with a postexposure period of 3 months.","effect":"et concentrations of 0, 1.5, 3, and 8 mg/m3 diethanolamine using the same dosing schedule as above, and recovery groups of 10 females were exposed to 3 or 8 mg/m3, with a postexposure period of 3 months. No dose- related clinical signs were observed. Liver weights of test, but not recovery, females dosed with 8 mg/m3 were statistically significantly increased. Laryngeal effects were similar to those described above. No microscopic changes were observed in the upper respiratory tract of recovery animals. The 90-day no observed effect concentration (NOAEC) was determined to be 1.5 mg/m3 diethanolamine. In inhalation studies, Sprague Dawley rats, Hartley guinea pigs, and beagle dogs (number per species and sex not speci- fied) were each exposed to 0.5 ppm diethanolamine for 6 h/d, 5 d/wk, for a total of 45 exposures.40 All animals survived until study termination. There were no clinical signs of toxicity and no evidence of irritation. No gross or microscopic lesions were observed at necropsy. Reproductive and Developmental Toxicity Dermal No developmental or reproductive effects were...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_003"} |
| CIR_vision_codex | NOAEL | =380 | mg/kg/d | rabbit | dermal | - | developmental toxicity | {"citation":"150, 500; 1,500; 6","dose":"ere dosed dermally with 150, 500, or 1,500 mg/kg/d dietha- nolamine in deionized water, 6 h/d, on days 6 to 15 of gestation, under an occlusive covering.","effect":"ere dosed dermally with 150, 500, or 1,500 mg/kg/d dietha- nolamine in deionized water, 6 h/d, on days 6 to 15 of gestation, under an occlusive covering. Dosing volume was 4 mL/kg/d. Control animals were dosed with vehicle only. Teratogenic effects were not seen at any dose. Dermal application of 500 mg/kg diethanolamine resulted in alterations in maternal hema- tological parameters but did not affect embryonal/fetal devel- opment. Other signs of maternal toxicity were seen at this dose and with 1,500 mg/kg/d. The NOEL for embryonal/fetal toxi- city was estimated to be 380 mg/kg/d, which incorporates an adjustment for the 10% to 24% deficit in expected dose that occurred on days 12 to 15 of gestation. Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were obs...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_004"} |
| CIR_vision_codex | NOAEL | =35 | mg/kg/d | mouse | oral | - | developmental toxicity | {"citation":"15; 35, 100; 350","dose":"Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering.","effect":"gestation. Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were observed at this dose. No developmental toxicity was observed, and there was no evidence of teratogeni- city at any dose. The NOEL for maternal toxicity of diethano- lamine in rabbits was 35 mg/kg/d, and the embryonal/fetal NOEL was 350 mg/kg/d diethanolamine. Oral In a Chernoff-Kavlock screening test, groups of 4 gravid CD-1 mice were dosed orally, by gavage, with 200, 380, 720, 1,370, or 2,605 mg/kg bw diethanolamine in distilled water on days 6 to 15 of gestation; a control group was dosed with vehicle only.36 Two, 3, and 4 of 4 animals of the 720, 1,370, and 2,605 mg/kg dose groups died during the study. Rough hair coats were observed at all dose levels. Group of 50 female gravid CD-1 femal...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_005"} |
| CIR_vision_codex | NOAEL | =350 | mg/kg/d | mouse | oral | - | developmental toxicity | {"citation":"6; 18; 2","dose":"Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only.","effect":"ine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were observed at this dose. No developmental toxicity was observed, and there was no evidence of teratogeni- city at any dose. The NOEL for maternal toxicity of diethano- lamine in rabbits was 35 mg/kg/d, and the embryonal/fetal NOEL was 350 mg/kg/d diethanolamine. Oral In a Chernoff-Kavlock screening test, groups of 4 gravid CD-1 mice were dosed orally, by gavage, with 200, 380, 720, 1,370, or 2,605 mg/kg bw diethanolamine in distilled water on days 6 to 15 of gestation; a control group was dosed with vehicle only.36 Two, 3, and 4 of 4 animals of the 720, 1,370, and 2,605 mg/kg dose groups died during the study. Rough hair coats were observed at all dose levels. Group of 50 female gravid CD-1 female mice were dosed orally, by gavage, with 0 or 450 mg/kg bw diethanolamine in distilled water on d...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_006"} |
| CIR_vision_codex | NOAEL | =50 | mg/kg/d | rat | oral | - | developmental toxicity | {"citation":"0; 3; 50, 200, 500, 800","dose":"Gravid Sprague Dawley rats were dosed orally, by gavage, with 50, 200, 500, 800, or 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation.44 Maternal mortality was observed at doses of 50 to 1200 mg/kg/d.","effect":"ber of live litters on day 0 were not affected by dosing, but the average number of live litters on day 3 was decreased. Mean bws and bw gains of pups were also decreased on PND 3. Gravid Sprague Dawley rats were dosed orally, by gavage, with 50, 200, 500, 800, or 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation.44 Maternal mortality was observed at doses of 50 to 1200 mg/kg/d. At doses of 50 and 200 mg/kg/d, no differences in gross developmental end points were found between test and control animals. The NOEL for embryonal/ Fiume et al 101S","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_007"} |
| CIR_vision_codex | NOAEL | =10 | mg/kg/d | mouse | dermal | 4 weeks | NOAEL study | {"citation":"74; 4; 10","dose":"The dose–response, reversibility, and strain dependence of diethanolamine effects on hepatic choline deficiency were studied.74 B6C3F1 mice were dosed dermally with diethanolamine in ethanol for 4 weeks.","effect":"were seen without fatty livers, an observation often associated with cho- line deficiency. The dose–response, reversibility, and strain dependence of diethanolamine effects on hepatic choline deficiency were studied.74 B6C3F1 mice were dosed dermally with diethanolamine in ethanol for 4 weeks. Control animals were either not dosed or dosed with ethanol only. The pat- tern of changes observed in choline metabolites after dietha- nolamine treatment was very similar to that observed in choline-deficient mice, and the NOEL for diethanolamine- induced changes in choline homeostasis was 10 mg/kg/d. Fatty livers were not observed. The reactions were dose dependent and reversible. Strain dependency was evaluated by dosing male C57BL/6 mice with 0 or 160 mg diethano- lamine/kg bw for a similar 4-week period. Hepatic choline deficiency was found to be strain dependent. Dermal appli- cation of 95% ethanol decreased hepatic betaine levels, sug- gesting that the use of ethanol as a vehicle for dermal application of diethanolamine could exacerbate the bio- chemical effects of diethanolamine. Oc...","page":17,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_009"} |
| CIR_vision_codex | NOAEL | =200 | mg/kg/ d | rat | oral | - | developmental toxicity | {"citation":"(20; 320; 1,500","dose":"creased at all doses (20-320 mg/kg) in a dose-dependent manner.","effect":"creased at all doses (20-320 mg/kg) in a dose-dependent manner. In rats and rabbits, dermal dosing with up to 1,500 mg/kg and 350 mg/kg diethanolamine, respectively, during gestation did not have any fetotoxic or teratogenic effects. The NOEL for embryonal/fetal toxicity was 380 mg/kg/d for rats and 350 mg/kg/d for rabbits. In an oral developmental toxicity study in which rats were dosed with up to 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation, maternal mortality was observed at doses of \u000550 mg/kg; the NOEL for embryonal/fetal toxicity was 200 mg/kg/ d. In a study in which gravid rats were dosed orally with up to 300 mg/kg/d diethanolamine, the dams of the 300 mg/kg group were killed due to excessive toxicity; the LD50 was calculated to be 218 mg/kg. The LOAEL for both maternal toxicity and teratogenicity was 125 mg/kg/d. In a developmental toxicity study in which rats were exposed by inhalation to diethanolamine on days 6 to 15 of gestation, the NOAEC for both maternal and developmental toxicity was 0.05 mg/L and the NOAEC for teratogenicity was >0.2 mg/L. Diethanolam...","page":18,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_010"} |
| CIR_vision_codex | NOAEL | =250 | mg/kg | rat | - | 5 d | NOAEL study | {"citation":"250; 500; 99","dose":", 250, and 500 mg/kg bw/d diethanolamine (purity >99%) in 95% ethanol were applied to the backs of 10 male and 10 female F344/N rats, 5 d/wk for 13 weeks.35 Vehicle only was applied to the negative control group.","effect":", 250, and 500 mg/kg bw/d diethanolamine (purity >99%) in 95% ethanol were applied to the backs of 10 male and 10 female F344/N rats, 5 d/wk for 13 weeks.35 Vehicle only was applied to the negative control group. (The square area of the dose site was not provided.) One male and 2 females given 500 mg/kg died or were killed in moribund condition during the study. Clinical signs of toxicity, observed in males and females given 125 to 500 mg/kg diethanolamine, were irritation and crusting at the application site. The no observable adverse effect level (NOAEL) for ulceration was 125 mg/kg for male rats and 63 mg/kg for female rats. Final mean bws were statistically sig- nificantly decreased in males dosed with 250 and 500 mg/kg and females dosed with 125 to 500 mg/kg diethanolamine. Increases in absolute and relative kidney weights were observed with increased incidence of renal lesions. Nephropa- thy was observed in lower and mid-dose females, but a clear treatment effect was not seen in males. Increases in absolute and relative liver weights were not accompanied by an increase in he...","page":11,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_001"} |
| CIR_vision_codex | NOAEL | =250 | mg/kg d | rat | oral | 7 weeks | oral toxicity | {"citation":"125; 500; (7","dose":"ed with 125 to 500 mg/kg diethanolamine.","effect":"ed with 125 to 500 mg/kg diethanolamine. Increases in absolute and relative kidney weights were observed with increased incidence of renal lesions. Nephropa- thy was observed in lower and mid-dose females, but a clear treatment effect was not seen in males. Increases in absolute and relative liver weights were not accompanied by an increase in hepatic lesions. Demyelination in the medulla oblongata was seen in all high-dose animals (7 females) given 250 mg/kg diethanolamine; this lesion was minimal in severity. An NOAEL was not achieved regarding hematological changes, but the researchers did note that the differences between con- trols and male rats exposed to 32 mg/kg diethanolamine were minimal. Oral. A previous safety assessment of triethanolamine, dietha- nolamine, and monoethanolamine reported on oral studies con- ducted in which neonatal rats were dosed with 1 to 3 mM/kg/d diethanolamine, as a neutralized salt, on days 5 to 15 after birth, male rats were dosed with 4 mg/mL neutralized diethanolamine in drinking water for 7 weeks, and rats were fed 0 to 0.68 g/kg/d diethanol...","page":11,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_002"} |
| CIR_vision_codex | NOAEL | =1.5 | mg/m3 | rat | inhalation | 3 months | repeated dose toxicity | {"citation":"0, 1; 5, 3; 8","dose":"et concentrations of 0, 1.5, 3, and 8 mg/m3 diethanolamine using the same dosing schedule as above, and recovery groups of 10 females were exposed to 3 or 8 mg/m3, with a postexposure period of 3 months.","effect":"et concentrations of 0, 1.5, 3, and 8 mg/m3 diethanolamine using the same dosing schedule as above, and recovery groups of 10 females were exposed to 3 or 8 mg/m3, with a postexposure period of 3 months. No dose- related clinical signs were observed. Liver weights of test, but not recovery, females dosed with 8 mg/m3 were statistically significantly increased. Laryngeal effects were similar to those described above. No microscopic changes were observed in the upper respiratory tract of recovery animals. The 90-day no observed effect concentration (NOAEC) was determined to be 1.5 mg/m3 diethanolamine. In inhalation studies, Sprague Dawley rats, Hartley guinea pigs, and beagle dogs (number per species and sex not speci- fied) were each exposed to 0.5 ppm diethanolamine for 6 h/d, 5 d/wk, for a total of 45 exposures.40 All animals survived until study termination. There were no clinical signs of toxicity and no evidence of irritation. No gross or microscopic lesions were observed at necropsy. Reproductive and Developmental Toxicity Dermal No developmental or reproductive effects were...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_003"} |
| CIR_vision_codex | NOAEL | =380 | mg/kg/d | rabbit | dermal | - | developmental toxicity | {"citation":"150, 500; 1,500; 6","dose":"ere dosed dermally with 150, 500, or 1,500 mg/kg/d dietha- nolamine in deionized water, 6 h/d, on days 6 to 15 of gestation, under an occlusive covering.","effect":"ere dosed dermally with 150, 500, or 1,500 mg/kg/d dietha- nolamine in deionized water, 6 h/d, on days 6 to 15 of gestation, under an occlusive covering. Dosing volume was 4 mL/kg/d. Control animals were dosed with vehicle only. Teratogenic effects were not seen at any dose. Dermal application of 500 mg/kg diethanolamine resulted in alterations in maternal hema- tological parameters but did not affect embryonal/fetal devel- opment. Other signs of maternal toxicity were seen at this dose and with 1,500 mg/kg/d. The NOEL for embryonal/fetal toxi- city was estimated to be 380 mg/kg/d, which incorporates an adjustment for the 10% to 24% deficit in expected dose that occurred on days 12 to 15 of gestation. Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were obs...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_004"} |
| CIR_vision_codex | NOAEL | =35 | mg/kg/d | mouse | oral | - | developmental toxicity | {"citation":"15; 35, 100; 350","dose":"Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering.","effect":"gestation. Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were observed at this dose. No developmental toxicity was observed, and there was no evidence of teratogeni- city at any dose. The NOEL for maternal toxicity of diethano- lamine in rabbits was 35 mg/kg/d, and the embryonal/fetal NOEL was 350 mg/kg/d diethanolamine. Oral In a Chernoff-Kavlock screening test, groups of 4 gravid CD-1 mice were dosed orally, by gavage, with 200, 380, 720, 1,370, or 2,605 mg/kg bw diethanolamine in distilled water on days 6 to 15 of gestation; a control group was dosed with vehicle only.36 Two, 3, and 4 of 4 animals of the 720, 1,370, and 2,605 mg/kg dose groups died during the study. Rough hair coats were observed at all dose levels. Group of 50 female gravid CD-1 femal...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_005"} |
| CIR_vision_codex | NOAEL | =350 | mg/kg/d | mouse | oral | - | developmental toxicity | {"citation":"6; 18; 2","dose":"Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only.","effect":"ine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were observed at this dose. No developmental toxicity was observed, and there was no evidence of teratogeni- city at any dose. The NOEL for maternal toxicity of diethano- lamine in rabbits was 35 mg/kg/d, and the embryonal/fetal NOEL was 350 mg/kg/d diethanolamine. Oral In a Chernoff-Kavlock screening test, groups of 4 gravid CD-1 mice were dosed orally, by gavage, with 200, 380, 720, 1,370, or 2,605 mg/kg bw diethanolamine in distilled water on days 6 to 15 of gestation; a control group was dosed with vehicle only.36 Two, 3, and 4 of 4 animals of the 720, 1,370, and 2,605 mg/kg dose groups died during the study. Rough hair coats were observed at all dose levels. Group of 50 female gravid CD-1 female mice were dosed orally, by gavage, with 0 or 450 mg/kg bw diethanolamine in distilled water on d...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_006"} |
| CIR_vision_codex | NOAEL | =50 | mg/kg/d | rat | oral | - | developmental toxicity | {"citation":"0; 3; 50, 200, 500, 800","dose":"Gravid Sprague Dawley rats were dosed orally, by gavage, with 50, 200, 500, 800, or 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation.44 Maternal mortality was observed at doses of 50 to 1200 mg/kg/d.","effect":"ber of live litters on day 0 were not affected by dosing, but the average number of live litters on day 3 was decreased. Mean bws and bw gains of pups were also decreased on PND 3. Gravid Sprague Dawley rats were dosed orally, by gavage, with 50, 200, 500, 800, or 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation.44 Maternal mortality was observed at doses of 50 to 1200 mg/kg/d. At doses of 50 and 200 mg/kg/d, no differences in gross developmental end points were found between test and control animals. The NOEL for embryonal/ Fiume et al 101S","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_007"} |
| CIR_vision_codex | NOAEL | =10 | mg/kg/d | mouse | dermal | 4 weeks | NOAEL study | {"citation":"74; 4; 10","dose":"The dose–response, reversibility, and strain dependence of diethanolamine effects on hepatic choline deficiency were studied.74 B6C3F1 mice were dosed dermally with diethanolamine in ethanol for 4 weeks.","effect":"were seen without fatty livers, an observation often associated with cho- line deficiency. The dose–response, reversibility, and strain dependence of diethanolamine effects on hepatic choline deficiency were studied.74 B6C3F1 mice were dosed dermally with diethanolamine in ethanol for 4 weeks. Control animals were either not dosed or dosed with ethanol only. The pat- tern of changes observed in choline metabolites after dietha- nolamine treatment was very similar to that observed in choline-deficient mice, and the NOEL for diethanolamine- induced changes in choline homeostasis was 10 mg/kg/d. Fatty livers were not observed. The reactions were dose dependent and reversible. Strain dependency was evaluated by dosing male C57BL/6 mice with 0 or 160 mg diethano- lamine/kg bw for a similar 4-week period. Hepatic choline deficiency was found to be strain dependent. Dermal appli- cation of 95% ethanol decreased hepatic betaine levels, sug- gesting that the use of ethanol as a vehicle for dermal application of diethanolamine could exacerbate the bio- chemical effects of diethanolamine. Oc...","page":17,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_009"} |
| CIR_vision_codex | NOAEL | =200 | mg/kg/ d | rat | oral | - | developmental toxicity | {"citation":"(20; 320; 1,500","dose":"creased at all doses (20-320 mg/kg) in a dose-dependent manner.","effect":"creased at all doses (20-320 mg/kg) in a dose-dependent manner. In rats and rabbits, dermal dosing with up to 1,500 mg/kg and 350 mg/kg diethanolamine, respectively, during gestation did not have any fetotoxic or teratogenic effects. The NOEL for embryonal/fetal toxicity was 380 mg/kg/d for rats and 350 mg/kg/d for rabbits. In an oral developmental toxicity study in which rats were dosed with up to 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation, maternal mortality was observed at doses of \u000550 mg/kg; the NOEL for embryonal/fetal toxicity was 200 mg/kg/ d. In a study in which gravid rats were dosed orally with up to 300 mg/kg/d diethanolamine, the dams of the 300 mg/kg group were killed due to excessive toxicity; the LD50 was calculated to be 218 mg/kg. The LOAEL for both maternal toxicity and teratogenicity was 125 mg/kg/d. In a developmental toxicity study in which rats were exposed by inhalation to diethanolamine on days 6 to 15 of gestation, the NOAEC for both maternal and developmental toxicity was 0.05 mg/L and the NOAEC for teratogenicity was >0.2 mg/L. Diethanolam...","page":18,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_010"} |
| CIR_vision_codex | NOAEL | =250 | mg/kg | rat | - | 5 d | NOAEL study | {"citation":"250; 500; 99","dose":", 250, and 500 mg/kg bw/d diethanolamine (purity >99%) in 95% ethanol were applied to the backs of 10 male and 10 female F344/N rats, 5 d/wk for 13 weeks.35 Vehicle only was applied to the negative control group.","effect":", 250, and 500 mg/kg bw/d diethanolamine (purity >99%) in 95% ethanol were applied to the backs of 10 male and 10 female F344/N rats, 5 d/wk for 13 weeks.35 Vehicle only was applied to the negative control group. (The square area of the dose site was not provided.) One male and 2 females given 500 mg/kg died or were killed in moribund condition during the study. Clinical signs of toxicity, observed in males and females given 125 to 500 mg/kg diethanolamine, were irritation and crusting at the application site. The no observable adverse effect level (NOAEL) for ulceration was 125 mg/kg for male rats and 63 mg/kg for female rats. Final mean bws were statistically sig- nificantly decreased in males dosed with 250 and 500 mg/kg and females dosed with 125 to 500 mg/kg diethanolamine. Increases in absolute and relative kidney weights were observed with increased incidence of renal lesions. Nephropa- thy was observed in lower and mid-dose females, but a clear treatment effect was not seen in males. Increases in absolute and relative liver weights were not accompanied by an increase in he...","page":11,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_001"} |
| CIR_vision_codex | NOAEL | =250 | mg/kg d | rat | oral | 7 weeks | oral toxicity | {"citation":"125; 500; (7","dose":"ed with 125 to 500 mg/kg diethanolamine.","effect":"ed with 125 to 500 mg/kg diethanolamine. Increases in absolute and relative kidney weights were observed with increased incidence of renal lesions. Nephropa- thy was observed in lower and mid-dose females, but a clear treatment effect was not seen in males. Increases in absolute and relative liver weights were not accompanied by an increase in hepatic lesions. Demyelination in the medulla oblongata was seen in all high-dose animals (7 females) given 250 mg/kg diethanolamine; this lesion was minimal in severity. An NOAEL was not achieved regarding hematological changes, but the researchers did note that the differences between con- trols and male rats exposed to 32 mg/kg diethanolamine were minimal. Oral. A previous safety assessment of triethanolamine, dietha- nolamine, and monoethanolamine reported on oral studies con- ducted in which neonatal rats were dosed with 1 to 3 mM/kg/d diethanolamine, as a neutralized salt, on days 5 to 15 after birth, male rats were dosed with 4 mg/mL neutralized diethanolamine in drinking water for 7 weeks, and rats were fed 0 to 0.68 g/kg/d diethanol...","page":11,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_002"} |
| CIR_vision_codex | NOAEL | =1.5 | mg/m3 | rat | inhalation | 3 months | repeated dose toxicity | {"citation":"0, 1; 5, 3; 8","dose":"et concentrations of 0, 1.5, 3, and 8 mg/m3 diethanolamine using the same dosing schedule as above, and recovery groups of 10 females were exposed to 3 or 8 mg/m3, with a postexposure period of 3 months.","effect":"et concentrations of 0, 1.5, 3, and 8 mg/m3 diethanolamine using the same dosing schedule as above, and recovery groups of 10 females were exposed to 3 or 8 mg/m3, with a postexposure period of 3 months. No dose- related clinical signs were observed. Liver weights of test, but not recovery, females dosed with 8 mg/m3 were statistically significantly increased. Laryngeal effects were similar to those described above. No microscopic changes were observed in the upper respiratory tract of recovery animals. The 90-day no observed effect concentration (NOAEC) was determined to be 1.5 mg/m3 diethanolamine. In inhalation studies, Sprague Dawley rats, Hartley guinea pigs, and beagle dogs (number per species and sex not speci- fied) were each exposed to 0.5 ppm diethanolamine for 6 h/d, 5 d/wk, for a total of 45 exposures.40 All animals survived until study termination. There were no clinical signs of toxicity and no evidence of irritation. No gross or microscopic lesions were observed at necropsy. Reproductive and Developmental Toxicity Dermal No developmental or reproductive effects were...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_003"} |
| CIR_vision_codex | NOAEL | =380 | mg/kg/d | rabbit | dermal | - | developmental toxicity | {"citation":"150, 500; 1,500; 6","dose":"ere dosed dermally with 150, 500, or 1,500 mg/kg/d dietha- nolamine in deionized water, 6 h/d, on days 6 to 15 of gestation, under an occlusive covering.","effect":"ere dosed dermally with 150, 500, or 1,500 mg/kg/d dietha- nolamine in deionized water, 6 h/d, on days 6 to 15 of gestation, under an occlusive covering. Dosing volume was 4 mL/kg/d. Control animals were dosed with vehicle only. Teratogenic effects were not seen at any dose. Dermal application of 500 mg/kg diethanolamine resulted in alterations in maternal hema- tological parameters but did not affect embryonal/fetal devel- opment. Other signs of maternal toxicity were seen at this dose and with 1,500 mg/kg/d. The NOEL for embryonal/fetal toxi- city was estimated to be 380 mg/kg/d, which incorporates an adjustment for the 10% to 24% deficit in expected dose that occurred on days 12 to 15 of gestation. Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were obs...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_004"} |
| CIR_vision_codex | NOAEL | =35 | mg/kg/d | mouse | oral | - | developmental toxicity | {"citation":"15; 35, 100; 350","dose":"Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering.","effect":"gestation. Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were observed at this dose. No developmental toxicity was observed, and there was no evidence of teratogeni- city at any dose. The NOEL for maternal toxicity of diethano- lamine in rabbits was 35 mg/kg/d, and the embryonal/fetal NOEL was 350 mg/kg/d diethanolamine. Oral In a Chernoff-Kavlock screening test, groups of 4 gravid CD-1 mice were dosed orally, by gavage, with 200, 380, 720, 1,370, or 2,605 mg/kg bw diethanolamine in distilled water on days 6 to 15 of gestation; a control group was dosed with vehicle only.36 Two, 3, and 4 of 4 animals of the 720, 1,370, and 2,605 mg/kg dose groups died during the study. Rough hair coats were observed at all dose levels. Group of 50 female gravid CD-1 femal...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_005"} |
| CIR_vision_codex | NOAEL | =350 | mg/kg/d | mouse | oral | - | developmental toxicity | {"citation":"6; 18; 2","dose":"Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only.","effect":"ine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were observed at this dose. No developmental toxicity was observed, and there was no evidence of teratogeni- city at any dose. The NOEL for maternal toxicity of diethano- lamine in rabbits was 35 mg/kg/d, and the embryonal/fetal NOEL was 350 mg/kg/d diethanolamine. Oral In a Chernoff-Kavlock screening test, groups of 4 gravid CD-1 mice were dosed orally, by gavage, with 200, 380, 720, 1,370, or 2,605 mg/kg bw diethanolamine in distilled water on days 6 to 15 of gestation; a control group was dosed with vehicle only.36 Two, 3, and 4 of 4 animals of the 720, 1,370, and 2,605 mg/kg dose groups died during the study. Rough hair coats were observed at all dose levels. Group of 50 female gravid CD-1 female mice were dosed orally, by gavage, with 0 or 450 mg/kg bw diethanolamine in distilled water on d...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_006"} |
| CIR_vision_codex | NOAEL | =50 | mg/kg/d | rat | oral | - | developmental toxicity | {"citation":"0; 3; 50, 200, 500, 800","dose":"Gravid Sprague Dawley rats were dosed orally, by gavage, with 50, 200, 500, 800, or 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation.44 Maternal mortality was observed at doses of 50 to 1200 mg/kg/d.","effect":"ber of live litters on day 0 were not affected by dosing, but the average number of live litters on day 3 was decreased. Mean bws and bw gains of pups were also decreased on PND 3. Gravid Sprague Dawley rats were dosed orally, by gavage, with 50, 200, 500, 800, or 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation.44 Maternal mortality was observed at doses of 50 to 1200 mg/kg/d. At doses of 50 and 200 mg/kg/d, no differences in gross developmental end points were found between test and control animals. The NOEL for embryonal/ Fiume et al 101S","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_007"} |
| CIR_vision_codex | NOAEL | =10 | mg/kg/d | mouse | dermal | 4 weeks | NOAEL study | {"citation":"74; 4; 10","dose":"The dose–response, reversibility, and strain dependence of diethanolamine effects on hepatic choline deficiency were studied.74 B6C3F1 mice were dosed dermally with diethanolamine in ethanol for 4 weeks.","effect":"were seen without fatty livers, an observation often associated with cho- line deficiency. The dose–response, reversibility, and strain dependence of diethanolamine effects on hepatic choline deficiency were studied.74 B6C3F1 mice were dosed dermally with diethanolamine in ethanol for 4 weeks. Control animals were either not dosed or dosed with ethanol only. The pat- tern of changes observed in choline metabolites after dietha- nolamine treatment was very similar to that observed in choline-deficient mice, and the NOEL for diethanolamine- induced changes in choline homeostasis was 10 mg/kg/d. Fatty livers were not observed. The reactions were dose dependent and reversible. Strain dependency was evaluated by dosing male C57BL/6 mice with 0 or 160 mg diethano- lamine/kg bw for a similar 4-week period. Hepatic choline deficiency was found to be strain dependent. Dermal appli- cation of 95% ethanol decreased hepatic betaine levels, sug- gesting that the use of ethanol as a vehicle for dermal application of diethanolamine could exacerbate the bio- chemical effects of diethanolamine. Oc...","page":17,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_009"} |
| CIR_vision_codex | NOAEL | =200 | mg/kg/ d | rat | oral | - | developmental toxicity | {"citation":"(20; 320; 1,500","dose":"creased at all doses (20-320 mg/kg) in a dose-dependent manner.","effect":"creased at all doses (20-320 mg/kg) in a dose-dependent manner. In rats and rabbits, dermal dosing with up to 1,500 mg/kg and 350 mg/kg diethanolamine, respectively, during gestation did not have any fetotoxic or teratogenic effects. The NOEL for embryonal/fetal toxicity was 380 mg/kg/d for rats and 350 mg/kg/d for rabbits. In an oral developmental toxicity study in which rats were dosed with up to 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation, maternal mortality was observed at doses of \u000550 mg/kg; the NOEL for embryonal/fetal toxicity was 200 mg/kg/ d. In a study in which gravid rats were dosed orally with up to 300 mg/kg/d diethanolamine, the dams of the 300 mg/kg group were killed due to excessive toxicity; the LD50 was calculated to be 218 mg/kg. The LOAEL for both maternal toxicity and teratogenicity was 125 mg/kg/d. In a developmental toxicity study in which rats were exposed by inhalation to diethanolamine on days 6 to 15 of gestation, the NOAEC for both maternal and developmental toxicity was 0.05 mg/L and the NOAEC for teratogenicity was >0.2 mg/L. Diethanolam...","page":18,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_010"} |
| CIR_vision_codex | NOAEL | =250 | mg/kg | rat | - | 5 d | NOAEL study | {"citation":"250; 500; 99","dose":", 250, and 500 mg/kg bw/d diethanolamine (purity >99%) in 95% ethanol were applied to the backs of 10 male and 10 female F344/N rats, 5 d/wk for 13 weeks.35 Vehicle only was applied to the negative control group.","effect":", 250, and 500 mg/kg bw/d diethanolamine (purity >99%) in 95% ethanol were applied to the backs of 10 male and 10 female F344/N rats, 5 d/wk for 13 weeks.35 Vehicle only was applied to the negative control group. (The square area of the dose site was not provided.) One male and 2 females given 500 mg/kg died or were killed in moribund condition during the study. Clinical signs of toxicity, observed in males and females given 125 to 500 mg/kg diethanolamine, were irritation and crusting at the application site. The no observable adverse effect level (NOAEL) for ulceration was 125 mg/kg for male rats and 63 mg/kg for female rats. Final mean bws were statistically sig- nificantly decreased in males dosed with 250 and 500 mg/kg and females dosed with 125 to 500 mg/kg diethanolamine. Increases in absolute and relative kidney weights were observed with increased incidence of renal lesions. Nephropa- thy was observed in lower and mid-dose females, but a clear treatment effect was not seen in males. Increases in absolute and relative liver weights were not accompanied by an increase in he...","page":11,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_001"} |
| CIR_vision_codex | NOAEL | =250 | mg/kg d | rat | oral | 7 weeks | oral toxicity | {"citation":"125; 500; (7","dose":"ed with 125 to 500 mg/kg diethanolamine.","effect":"ed with 125 to 500 mg/kg diethanolamine. Increases in absolute and relative kidney weights were observed with increased incidence of renal lesions. Nephropa- thy was observed in lower and mid-dose females, but a clear treatment effect was not seen in males. Increases in absolute and relative liver weights were not accompanied by an increase in hepatic lesions. Demyelination in the medulla oblongata was seen in all high-dose animals (7 females) given 250 mg/kg diethanolamine; this lesion was minimal in severity. An NOAEL was not achieved regarding hematological changes, but the researchers did note that the differences between con- trols and male rats exposed to 32 mg/kg diethanolamine were minimal. Oral. A previous safety assessment of triethanolamine, dietha- nolamine, and monoethanolamine reported on oral studies con- ducted in which neonatal rats were dosed with 1 to 3 mM/kg/d diethanolamine, as a neutralized salt, on days 5 to 15 after birth, male rats were dosed with 4 mg/mL neutralized diethanolamine in drinking water for 7 weeks, and rats were fed 0 to 0.68 g/kg/d diethanol...","page":11,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_002"} |
| CIR_vision_codex | NOAEL | =1.5 | mg/m3 | rat | inhalation | 3 months | repeated dose toxicity | {"citation":"0, 1; 5, 3; 8","dose":"et concentrations of 0, 1.5, 3, and 8 mg/m3 diethanolamine using the same dosing schedule as above, and recovery groups of 10 females were exposed to 3 or 8 mg/m3, with a postexposure period of 3 months.","effect":"et concentrations of 0, 1.5, 3, and 8 mg/m3 diethanolamine using the same dosing schedule as above, and recovery groups of 10 females were exposed to 3 or 8 mg/m3, with a postexposure period of 3 months. No dose- related clinical signs were observed. Liver weights of test, but not recovery, females dosed with 8 mg/m3 were statistically significantly increased. Laryngeal effects were similar to those described above. No microscopic changes were observed in the upper respiratory tract of recovery animals. The 90-day no observed effect concentration (NOAEC) was determined to be 1.5 mg/m3 diethanolamine. In inhalation studies, Sprague Dawley rats, Hartley guinea pigs, and beagle dogs (number per species and sex not speci- fied) were each exposed to 0.5 ppm diethanolamine for 6 h/d, 5 d/wk, for a total of 45 exposures.40 All animals survived until study termination. There were no clinical signs of toxicity and no evidence of irritation. No gross or microscopic lesions were observed at necropsy. Reproductive and Developmental Toxicity Dermal No developmental or reproductive effects were...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_003"} |
| CIR_vision_codex | NOAEL | =380 | mg/kg/d | rabbit | dermal | - | developmental toxicity | {"citation":"150, 500; 1,500; 6","dose":"ere dosed dermally with 150, 500, or 1,500 mg/kg/d dietha- nolamine in deionized water, 6 h/d, on days 6 to 15 of gestation, under an occlusive covering.","effect":"ere dosed dermally with 150, 500, or 1,500 mg/kg/d dietha- nolamine in deionized water, 6 h/d, on days 6 to 15 of gestation, under an occlusive covering. Dosing volume was 4 mL/kg/d. Control animals were dosed with vehicle only. Teratogenic effects were not seen at any dose. Dermal application of 500 mg/kg diethanolamine resulted in alterations in maternal hema- tological parameters but did not affect embryonal/fetal devel- opment. Other signs of maternal toxicity were seen at this dose and with 1,500 mg/kg/d. The NOEL for embryonal/fetal toxi- city was estimated to be 380 mg/kg/d, which incorporates an adjustment for the 10% to 24% deficit in expected dose that occurred on days 12 to 15 of gestation. Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were obs...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_004"} |
| CIR_vision_codex | NOAEL | =35 | mg/kg/d | mouse | oral | - | developmental toxicity | {"citation":"15; 35, 100; 350","dose":"Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering.","effect":"gestation. Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were observed at this dose. No developmental toxicity was observed, and there was no evidence of teratogeni- city at any dose. The NOEL for maternal toxicity of diethano- lamine in rabbits was 35 mg/kg/d, and the embryonal/fetal NOEL was 350 mg/kg/d diethanolamine. Oral In a Chernoff-Kavlock screening test, groups of 4 gravid CD-1 mice were dosed orally, by gavage, with 200, 380, 720, 1,370, or 2,605 mg/kg bw diethanolamine in distilled water on days 6 to 15 of gestation; a control group was dosed with vehicle only.36 Two, 3, and 4 of 4 animals of the 720, 1,370, and 2,605 mg/kg dose groups died during the study. Rough hair coats were observed at all dose levels. Group of 50 female gravid CD-1 femal...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_005"} |
| CIR_vision_codex | NOAEL | =350 | mg/kg/d | mouse | oral | - | developmental toxicity | {"citation":"6; 18; 2","dose":"Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only.","effect":"ine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were observed at this dose. No developmental toxicity was observed, and there was no evidence of teratogeni- city at any dose. The NOEL for maternal toxicity of diethano- lamine in rabbits was 35 mg/kg/d, and the embryonal/fetal NOEL was 350 mg/kg/d diethanolamine. Oral In a Chernoff-Kavlock screening test, groups of 4 gravid CD-1 mice were dosed orally, by gavage, with 200, 380, 720, 1,370, or 2,605 mg/kg bw diethanolamine in distilled water on days 6 to 15 of gestation; a control group was dosed with vehicle only.36 Two, 3, and 4 of 4 animals of the 720, 1,370, and 2,605 mg/kg dose groups died during the study. Rough hair coats were observed at all dose levels. Group of 50 female gravid CD-1 female mice were dosed orally, by gavage, with 0 or 450 mg/kg bw diethanolamine in distilled water on d...","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_006"} |
| CIR_vision_codex | NOAEL | =50 | mg/kg/d | rat | oral | - | developmental toxicity | {"citation":"0; 3; 50, 200, 500, 800","dose":"Gravid Sprague Dawley rats were dosed orally, by gavage, with 50, 200, 500, 800, or 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation.44 Maternal mortality was observed at doses of 50 to 1200 mg/kg/d.","effect":"ber of live litters on day 0 were not affected by dosing, but the average number of live litters on day 3 was decreased. Mean bws and bw gains of pups were also decreased on PND 3. Gravid Sprague Dawley rats were dosed orally, by gavage, with 50, 200, 500, 800, or 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation.44 Maternal mortality was observed at doses of 50 to 1200 mg/kg/d. At doses of 50 and 200 mg/kg/d, no differences in gross developmental end points were found between test and control animals. The NOEL for embryonal/ Fiume et al 101S","page":13,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_007"} |
| CIR_vision_codex | NOAEL | =10 | mg/kg/d | mouse | dermal | 4 weeks | NOAEL study | {"citation":"74; 4; 10","dose":"The dose–response, reversibility, and strain dependence of diethanolamine effects on hepatic choline deficiency were studied.74 B6C3F1 mice were dosed dermally with diethanolamine in ethanol for 4 weeks.","effect":"were seen without fatty livers, an observation often associated with cho- line deficiency. The dose–response, reversibility, and strain dependence of diethanolamine effects on hepatic choline deficiency were studied.74 B6C3F1 mice were dosed dermally with diethanolamine in ethanol for 4 weeks. Control animals were either not dosed or dosed with ethanol only. The pat- tern of changes observed in choline metabolites after dietha- nolamine treatment was very similar to that observed in choline-deficient mice, and the NOEL for diethanolamine- induced changes in choline homeostasis was 10 mg/kg/d. Fatty livers were not observed. The reactions were dose dependent and reversible. Strain dependency was evaluated by dosing male C57BL/6 mice with 0 or 160 mg diethano- lamine/kg bw for a similar 4-week period. Hepatic choline deficiency was found to be strain dependent. Dermal appli- cation of 95% ethanol decreased hepatic betaine levels, sug- gesting that the use of ethanol as a vehicle for dermal application of diethanolamine could exacerbate the bio- chemical effects of diethanolamine. Oc...","page":17,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_009"} |
| CIR_vision_codex | NOAEL | =200 | mg/kg/ d | rat | oral | - | developmental toxicity | {"citation":"(20; 320; 1,500","dose":"creased at all doses (20-320 mg/kg) in a dose-dependent manner.","effect":"creased at all doses (20-320 mg/kg) in a dose-dependent manner. In rats and rabbits, dermal dosing with up to 1,500 mg/kg and 350 mg/kg diethanolamine, respectively, during gestation did not have any fetotoxic or teratogenic effects. The NOEL for embryonal/fetal toxicity was 380 mg/kg/d for rats and 350 mg/kg/d for rabbits. In an oral developmental toxicity study in which rats were dosed with up to 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation, maternal mortality was observed at doses of \u000550 mg/kg; the NOEL for embryonal/fetal toxicity was 200 mg/kg/ d. In a study in which gravid rats were dosed orally with up to 300 mg/kg/d diethanolamine, the dams of the 300 mg/kg group were killed due to excessive toxicity; the LD50 was calculated to be 218 mg/kg. The LOAEL for both maternal toxicity and teratogenicity was 125 mg/kg/d. In a developmental toxicity study in which rats were exposed by inhalation to diethanolamine on days 6 to 15 of gestation, the NOAEC for both maternal and developmental toxicity was 0.05 mg/L and the NOAEC for teratogenicity was >0.2 mg/L. Diethanolam...","page":18,"pdf":"PRS575.pdf","row_type":"noael_study","study_id":"PRS575_noael_010"} |
California Proposition 65 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 listing | LCcancer | listing type | - | - | 2012-06-22 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2012-06-22","listing_mechanism":"LC","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | LCcancer | listing type | - | - | 2012-06-22 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2012-06-22","listing_mechanism":"LC","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | LCcancer | listing type | - | - | 2012-06-22 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2012-06-22","listing_mechanism":"LC","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2011 | IARC Monographs | {"additional_info":"volume_publication_year=2013","evaluation_year":2011,"source_table":"iarc_classifications","volume":"77, 101"} |
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2011 | IARC Monographs | {"additional_info":"volume_publication_year=2013","evaluation_year":2011,"source_table":"iarc_classifications","volume":"77, 101"} |
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2011 | IARC Monographs | {"additional_info":"volume_publication_year=2013","evaluation_year":2011,"source_table":"iarc_classifications","volume":"77, 101"} |
NTP_ICE_acute_oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =710 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1035; row=5551; data_type=In Vivo; mixture=Chemical; chemical_name=Diethanolamine; preferred_name=Diethanolamine; dtxsid=DTXSID3021932; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3021932; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =210 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1034; row=5552; data_type=In Vivo; mixture=Chemical; chemical_name=Diethanolamine; preferred_name=Diethanolamine; dtxsid=DTXSID3021932; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3021932; source_file=acute_oral.xlsx |
NTP_ICE_cancer 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=3744; Record_ID=cancer_5703; Data_Type=WOE; Formulation_Name=Diethanolamine; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/95; http://publications.iarc.fr/125; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_cancer | POLY-3 lowest dose | 40 | mg/kg bw/day | Mouse | Dermal | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=3735; Record_ID=cancer_5699; Data_Type=In Vivo; Formulation_Name=Diethanolamine; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=40; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dermal; Level_of_Evidence=Clear evidence; Tissue=Liver; Lesion=Hepatocellular carcinoma, hepatocellular adenoma, or hepatoblastoma; Reference=TR-478; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr478/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_cancer | POLY-3 lowest dose | 160 | mg/kg bw/day | Mouse | Dermal | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=3736; Record_ID=cancer_5699; Data_Type=In Vivo; Formulation_Name=Diethanolamine; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=160; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dermal; Level_of_Evidence=Clear evidence; Tissue=Kidney; Location=Renal tubule; Lesion=Adenoma; Reference=TR-478; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr478/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_cancer | Top dose | 160 | mg/kg | Mouse | Dermal | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=3737; Record_ID=cancer_5699; Data_Type=In Vivo; Formulation_Name=Diethanolamine; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=160; Response_Unit=mg/kg; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dermal; Reference=TR-478; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr478/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_cancer | Top dose | 64 | mg/kg | Rat | Dermal | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=3738; Record_ID=cancer_5698; Data_Type=In Vivo; Formulation_Name=Diethanolamine; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=64; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Male; Route=Dermal; Reference=TR-478; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr478/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_cancer | Top dose | 32 | mg/kg | Rat | Dermal | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=3747; Record_ID=cancer_5705; Data_Type=In Vivo; Formulation_Name=Diethanolamine; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=32; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Female; Route=Dermal; Reference=TR-478; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr478/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
NTP_ICE_dart 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_dart | LOEL | 15 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, Hematology | sheet=Data; excel_row=49725; Record_ID=dart_23877; Data_Type=In Vivo; DTXSID=DTXSID3021932; Assay=DART, Hematology; Endpoint=LOEL; Response=15; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0018935;CUI;Hematocrit procedure|UMLS;C0018941;CUI;Hematologic Tests; Reference=ToxRefDB v2 , ID = 5324; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_dart | LOEL | 15 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, Hematology | sheet=Data; excel_row=49726; Record_ID=dart_23878; Data_Type=In Vivo; DTXSID=DTXSID3021932; Assay=DART, Hematology; Endpoint=LOEL; Response=15; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0018935;CUI;Hematocrit procedure|UMLS;C0018941;CUI;Hematologic Tests; Reference=ToxRefDB v2 , ID = 5324; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_dart | LOEL | 15 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, Hematology | sheet=Data; excel_row=49727; Record_ID=dart_23882; Data_Type=In Vivo; DTXSID=DTXSID3021932; Assay=DART, Hematology; Endpoint=LOEL; Response=15; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0018935;CUI;Hematocrit procedure|UMLS;C0018941;CUI;Hematologic Tests; Reference=ToxRefDB v2 , ID = 5324; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_dart | LOEL | 1500 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=49728; Record_ID=dart_24045; Data_Type=In Vivo; DTXSID=DTXSID3021932; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=1500; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1282719;CUI;Incomplete ossification; Reference=ToxRefDB v2 , ID = 5324; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_dart | LOEL | 1500 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=49729; Record_ID=dart_24047; Data_Type=In Vivo; DTXSID=DTXSID3021932; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=1500; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1282719;CUI;Incomplete ossification; Reference=ToxRefDB v2 , ID = 5324; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_dart | LOEL | 1500 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=49730; Record_ID=dart_24049; Data_Type=In Vivo; DTXSID=DTXSID3021932; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=1500; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C0205394;CUI;Other; Reference=ToxRefDB v2 , ID = 5324; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_dart | LOEL | 1500 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=49731; Record_ID=dart_24051; Data_Type=In Vivo; DTXSID=DTXSID3021932; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=1500; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1282719;CUI;Incomplete ossification; Reference=ToxRefDB v2 , ID = 5324; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_dart | LOEL | 1500 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=49732; Record_ID=dart_24053; Data_Type=In Vivo; DTXSID=DTXSID3021932; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=1500; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1282719;CUI;Incomplete ossification; Reference=ToxRefDB v2 , ID = 5324; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_dart | LOEL | 1500 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=49733; Record_ID=dart_24054; Data_Type=In Vivo; DTXSID=DTXSID3021932; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=1500; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1282719;CUI;Incomplete ossification; Reference=ToxRefDB v2 , ID = 5324; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_dart | LOEL | 100 | mg/kg bw/day | Rabbit | Dermal | - | In Vivo; DART, In life observation | sheet=Data; excel_row=49734; Record_ID=dart_24082; Data_Type=In Vivo; DTXSID=DTXSID3021932; Assay=DART, In life observation; Endpoint=LOEL; Response=100; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 5325; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=7910; RecordID=ARPathway2016_567; DatasetName=ARPathway2016; DTXSID=DTXSID3021932; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
NTP_ICE_skin_sensitization 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD54, EC200 | 1281 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2342; Record_ID=skin_sensitization_invitro_572; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=1280.9000000000001; Reported_Response_Unit=ug/mL; Response=1281; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 1242.5 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2341; Record_ID=skin_sensitization_invitro_572; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=1242.5; Reported_Response_Unit=ug/mL; Response=1242.5; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 26.89 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8668; Record_ID=skin_sensitization_invitro_2399; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=26.89; Reported_Response_Unit=ug/mL; Response=26.89; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_skin_sensitization | CV70 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8667; Record_ID=skin_sensitization_invitro_2399; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_skin_sensitization | CV75 | 2277 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2343; Record_ID=skin_sensitization_invitro_572; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=h-CLAT; Endpoint=CV75; Reported_Response=2277; Reported_Response_Unit=ug/mL; Response=2277; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_skin_sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4750; Record_ID=skin_sensitization_invitro_1098; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
| NTP_ICE_skin_sensitization | Imax | 1 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4756; Record_ID=skin_sensitization_invitro_1098; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID3021932; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1; Reported_Response_Unit=Unitless; Response=1; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021932; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3021932 |
ToxRefDB_ToxRefDB_v3_pod.csv 28 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =79 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5308; toxval_study_source_id=studyid5308_Adult_F0_F_systemic; toxval_effect_list=hematology-reticulocyte-reticulocyte|organ weight-kidney-absolute|hematology-hematocrit (hct)-hematocrit (hct)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|organ weight-kidney-relative to body weight|in life observation-water consumption-water consumption|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-body weight-body weight gain|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|urinalysis-[other]-[other]|pathology microscopic-kidney-necrosis|urinalysis-glucose-glucose|urinalysis-protein-protein|in life observation-mortality-mortality|in life observation-clinical signs-reduced activity|in life observation-clinical signs-abnormal posture|in life observation-clinical signs-tremors; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =77 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5308; toxval_study_source_id=studyid5308_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|organ weight-kidney-relative to body weight|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-hematocrit (hct)-hematocrit (hct)|organ weight-kidney-absolute|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-reticulocyte-reticulocyte|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|urinalysis-[other]-[other]|in life observation-body weight-body weight gain|pathology gross-testes-reduced size|urinalysis-protein-protein|pathology microscopic-kidney-necrosis|pathology microscopic-epididymis-cellular alteration|in life observation-clinical signs-reduced activity|in life observation-mortality-mortality|in life observation-clinical signs-abnormal posture|in life observation-clinical signs-tremors|urinalysis-glucose-glucose|pathology microscopic-testes-degeneration|pathology microscopic-epididymis-oligospermia; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =326 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5311; toxval_study_source_id=studyid5311_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight|pathology microscopic-liver-cytologic alterations|in life observation-body weight-body weight|pathology microscopic-heart-degeneration|in life observation-clinical signs-abnormal posture|in life observation-clinical signs-fur (altered appearance)|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|in life observation-clinical signs-emaciation|in life observation-water consumption-water consumption; dose_level=2; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =205 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5311; toxval_study_source_id=studyid5311_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-cytologic alterations|organ weight-liver-absolute|organ weight-liver-relative to body weight|pathology microscopic-heart-degeneration|in life observation-clinical signs-emaciation|in life observation-water consumption-water consumption|in life observation-clinical signs-fur (altered appearance)|in life observation-body weight-body weight|in life observation-clinical signs-abnormal posture; dose_level=2; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =14 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5314; toxval_study_source_id=studyid5314_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-kidney-nephropathy|pathology microscopic-kidney-mineralization|organ weight-kidney-absolute|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|clinical chemistry-bile acids-bile acids|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|organ weight-liver-relative to body weight|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|organ weight-kidney-relative to body weight|in life observation-body weight-body weight|hematology-reticulocyte-reticulocyte|hematology-hematocrit (hct)-hematocrit (hct)|organ weight-liver-absolute|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-adrenal gland-vacuolization cytoplasmic|in life observation-clinical signs-tremors|pathology microscopic-brain-demyelination|in life observation-clinical signs-fur (altered appearance)|in life observation-clinical signs-emaciation|in life observation-clinical signs-abnormal posture|pathology microscopic-spinal cord-demyelination|pathology microscopic-kidney-necrosis|in life observation-water consumption-water consumption; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water (13-week study in rats). Toxicity Report Series No. 20.; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =25 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5314; toxval_study_source_id=studyid5314_Adult_F0_M_systemic; toxval_effect_list=hematology-hemoglobin (hgb)-hemoglobin (hgb)|organ weight-kidney-relative to body weight|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|organ weight-epididymis-relative to body weight|in life observation-water consumption-water consumption|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-body weight-body weight|clinical chemistry-bile acids-bile acids|organ weight-liver-relative to body weight|hematology-hematocrit (hct)-hematocrit (hct)|pathology microscopic-epididymis-hypospermia|pathology microscopic-epididymis-degeneration|organ weight-epididymis-absolute|pathology microscopic-testes-reduced spermatogenesis|pathology gross-testes-reduced size|organ weight-testes-absolute|pathology microscopic-kidney-mineralization|pathology microscopic-brain-demyelination|pathology microscopic-prostate-atrophy|in life observation-clinical signs-abnormal posture|organ weight-testes-relative to body weight|in life observation-clinical signs-fur (altered appearance)|pathology microscopic-seminal vesicle-atrophy|pathology gross-sperm measure-sperm count|pathology microscopic-spinal cord-demyelination|pathology microscopic-testes-degeneration|pathology gross-sperm measure-sperm motility|hematology-reticulocyte-reticulocyte|in life observation-clinical signs-emaciation|pathology microscopic-epididymis-congestion|in life observation-clinical signs-tremors|pathology microscopic-kidney-necrosis|pathology microscopic-kidney-nephropathy|pathology microscopic-adrenal gland-vacuolization cytoplasmic|in life observation-mortality-mortality; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water (13-week study in rats). Toxicity Report Series No. 20.; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =142 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5316; toxval_study_source_id=studyid5316_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|pathology microscopic-liver-cytologic alterations|organ weight-liver-relative to body weight|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|organ weight-kidney-relative to body weight|pathology microscopic-liver-necrosis|in life observation-body weight-body weight gain|organ weight-heart-relative to body weight|in life observation-clinical signs-tremors|in life observation-clinical signs-fur (altered appearance)|organ weight-heart-absolute|pathology microscopic-heart-degeneration|pathology microscopic-salivary glands-[other]|in life observation-mortality-mortality|in life observation-clinical signs-emaciation|pathology microscopic-kidney-nephropathy|in life observation-clinical signs-reduced activity|in life observation-clinical signs-abnormal posture|pathology microscopic-kidney-necrosis; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_13 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =104 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5316; toxval_study_source_id=studyid5316_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-nephropathy|organ weight-liver-absolute|pathology microscopic-liver-cytologic alterations|organ weight-liver-relative to body weight|organ weight-kidney-absolute|organ weight-kidney-relative to body weight|in life observation-body weight-body weight gain|in life observation-clinical signs-tremors|organ weight-heart-relative to body weight|pathology microscopic-salivary glands-[other]|pathology microscopic-liver-necrosis|in life observation-clinical signs-emaciation|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|in life observation-clinical signs-reduced activity|pathology microscopic-heart-degeneration|in life observation-clinical signs-fur (altered appearance)|in life observation-clinical signs-abnormal posture|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|in life observation-mortality-mortality|pathology microscopic-kidney-necrosis; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_13 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =125 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 day to 14 day | SAC | study_id=5317; toxval_study_source_id=studyid5317_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-hyperplasia|organ weight-kidney-absolute|organ weight-kidney-relative to body weight|hematology-hematocrit (hct)-hematocrit (hct)|pathology microscopic-skin-acanthosis|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-skin-inflammation|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-skin-ulcer|in life observation-clinical signs-emaciation|in life observation-mortality-mortality|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|in life observation-clinical signs-respiration (dyspnea)|pathology microscopic-kidney-necrosis|in life observation-clinical signs-scabbing|urinalysis-[other]-[other]|in life observation-body weight-body weight gain|in life observation-clinical signs-reduced activity; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_2 week study_Dermal_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =160 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 day to 14 day | SAC | study_id=5319; toxval_study_source_id=studyid5319_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-acanthosis|organ weight-liver-relative to body weight|organ weight-liver-absolute|pathology microscopic-liver-cytologic alterations|in life observation-mortality-mortality|in life observation-clinical signs-skin ulceration|pathology microscopic-skin-inflammation|pathology microscopic-skin-ulcer|in life observation-clinical signs-scabbing; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_2 week study_Dermal_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =32 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 week to 13 week | SUB | study_id=5320; toxval_study_source_id=studyid5320_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-hyperkeratosis|organ weight-kidney-relative to body weight|hematology-hemoglobin (hgb)-hemoglobin (hgb)|organ weight-liver-absolute|pathology microscopic-kidney-nephropathy|organ weight-kidney-absolute|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|organ weight-liver-relative to body weight|hematology-reticulocyte-reticulocyte|hematology-hematocrit (hct)-hematocrit (hct)|pathology microscopic-kidney-mineralization|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-skin-acanthosis|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|pathology microscopic-skin-inflammation|in life observation-clinical signs-scabbing|in life observation-body weight-body weight|pathology microscopic-skin-ulcer|pathology microscopic-kidney-necrosis|pathology microscopic-brain-demyelination|in life observation-mortality-mortality; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_13 week study_Dermal_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =80 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 week to 13 week | SUB | study_id=5322; toxval_study_source_id=studyid5322_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-absolute|organ weight-liver-absolute|organ weight-liver-relative to body weight|pathology microscopic-skin-acanthosis|pathology microscopic-liver-cytologic alterations|pathology microscopic-skin-inflammation|in life observation-clinical signs-scabbing|pathology gross-skin-thickened|pathology microscopic-skin-ulcer|organ weight-kidney-relative to body weight|organ weight-heart-absolute|organ weight-heart-relative to body weight|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|in life observation-mortality-mortality|pathology microscopic-kidney-necrosis|pathology microscopic-skin-hyperkeratosis|pathology microscopic-heart-degeneration|pathology microscopic-salivary glands-cellular alteration; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_13 week study_Dermal_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =8 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 week to 103 week | CHR | study_id=5327; toxval_study_source_id=studyid5327_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-exudate|pathology microscopic-skin-hyperkeratosis|pathology microscopic-kidney-nephropathy|pathology microscopic-skin-acanthosis|in life observation-clinical signs-skin ulceration|in life observation-body weight-body weight; dose_level=1; study_year=1999; study_citation=NTP_1999_Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies)_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =16 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 week to 103 week | CHR | study_id=5327; toxval_study_source_id=studyid5327_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-skin-acanthosis|pathology microscopic-skin-exudate|pathology microscopic-skin-hyperkeratosis|in life observation-clinical signs-skin ulceration|in life observation-body weight-body weight; dose_level=2; study_year=1999; study_citation=NTP_1999_Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies)_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =40 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 week to 103 week | CHR | study_id=5329; toxval_study_source_id=studyid5329_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-thyroid gland-hyperplasia|pathology microscopic-liver-hepatocellular adenoma|pathology microscopic-liver-syncytial alteration|in life observation-mortality-mortality|pathology microscopic-liver-hepatocellular carcinoma|pathology microscopic-skin-hyperkeratosis|pathology microscopic-skin-exudate; dose_level=1; study_year=1999; study_citation=NTP_1999_Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies)_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =371 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5308; toxval_study_source_id=studyid5308_Adult_F0_F_systemic; toxval_effect_list=urinalysis-[other]-[other]|pathology microscopic-kidney-necrosis|organ weight-kidney-relative to body weight|urinalysis-glucose-glucose|urinalysis-protein-protein|in life observation-body weight-body weight gain|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|organ weight-kidney-absolute; dose_level=3; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =319 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5308; toxval_study_source_id=studyid5308_Adult_F0_M_systemic; toxval_effect_list=organ weight-kidney-relative to body weight|organ weight-kidney-absolute|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh); dose_level=3; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =793 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5311; toxval_study_source_id=studyid5311_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to body weight; dose_level=3; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =415 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5311; toxval_study_source_id=studyid5311_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-cytologic alterations|organ weight-liver-absolute|organ weight-liver-relative to body weight; dose_level=3; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =1000 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 day to 14 day | SAC | study_id=5317; toxval_study_source_id=studyid5317_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-emaciation|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|in life observation-clinical signs-respiration (dyspnea)|pathology microscopic-kidney-necrosis|organ weight-kidney-absolute|organ weight-kidney-relative to body weight|urinalysis-[other]-[other]|in life observation-body weight-body weight gain|in life observation-clinical signs-reduced activity; dose_level=4; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_2 week study_Dermal_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =1250 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 day to 14 day | SAC | study_id=5319; toxval_study_source_id=studyid5319_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-acanthosis; dose_level=4; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_2 week study_Dermal_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5308; toxval_study_source_id=studyid5308_Adult_F0_F_systemic; toxval_effect_list=urinalysis-[other]-[other]|pathology microscopic-kidney-necrosis|in life observation-water consumption-water consumption|in life observation-clinical signs-abnormal posture|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|organ weight-kidney-relative to body weight|in life observation-mortality-mortality|in life observation-clinical signs-reduced activity|urinalysis-glucose-glucose|hematology-hemoglobin (hgb)-hemoglobin (hgb)|in life observation-body weight-body weight gain|urinalysis-protein-protein|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|hematology-hematocrit (hct)-hematocrit (hct)|hematology-reticulocyte-reticulocyte|in life observation-clinical signs-tremors|organ weight-kidney-absolute; dose_level=0; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =197 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5311; toxval_study_source_id=studyid5311_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-cytologic alterations|organ weight-liver-relative to body weight|organ weight-liver-absolute|pathology microscopic-heart-degeneration|in life observation-body weight-body weight|in life observation-clinical signs-abnormal posture|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|in life observation-clinical signs-fur (altered appearance)|in life observation-clinical signs-emaciation|in life observation-water consumption-water consumption; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =110 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5311; toxval_study_source_id=studyid5311_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-cytologic alterations|in life observation-water consumption-water consumption|in life observation-body weight-body weight|in life observation-clinical signs-fur (altered appearance)|organ weight-liver-absolute|in life observation-clinical signs-emaciation|pathology microscopic-heart-degeneration|organ weight-liver-relative to body weight|in life observation-clinical signs-abnormal posture; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =158 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5308; toxval_study_source_id=studyid5308_Adult_F0_F_systemic; toxval_effect_list=hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|organ weight-kidney-relative to body weight|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|in life observation-clinical signs-abnormal posture|urinalysis-[other]-[other]|in life observation-water consumption-water consumption|pathology microscopic-kidney-necrosis|hematology-hemoglobin (hgb)-hemoglobin (hgb)|urinalysis-glucose-glucose|in life observation-clinical signs-reduced activity|in life observation-mortality-mortality|urinalysis-protein-protein|in life observation-body weight-body weight gain|organ weight-kidney-absolute|hematology-reticulocyte-reticulocyte|in life observation-clinical signs-tremors|hematology-hematocrit (hct)-hematocrit (hct)|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh); dose_level=2; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =162 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5308; toxval_study_source_id=studyid5308_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|pathology microscopic-kidney-necrosis|in life observation-clinical signs-reduced activity|hematology-reticulocyte-reticulocyte|pathology microscopic-epididymis-cellular alteration|organ weight-kidney-relative to body weight|hematology-hemoglobin (hgb)-hemoglobin (hgb)|urinalysis-protein-protein|urinalysis-[other]-[other]|in life observation-water consumption-water consumption|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology gross-testes-reduced size|pathology microscopic-testes-degeneration|pathology microscopic-epididymis-oligospermia|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-hematocrit (hct)-hematocrit (hct)|urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|urinalysis-glucose-glucose|in life observation-clinical signs-tremors|organ weight-kidney-absolute|in life observation-mortality-mortality|in life observation-clinical signs-abnormal posture; dose_level=2; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =500 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 day to 14 day | SAC | study_id=5317; toxval_study_source_id=studyid5317_Adult_F0_F_systemic; toxval_effect_list=urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology microscopic-skin-inflammation|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-clinical signs-emaciation|hematology-hematocrit (hct)-hematocrit (hct)|in life observation-mortality-mortality|urinalysis-[other]-[other]|pathology microscopic-skin-hyperplasia|in life observation-body weight-body weight gain|in life observation-clinical signs-reduced activity|pathology microscopic-skin-ulcer|hematology-hemoglobin (hgb)-hemoglobin (hgb)|organ weight-kidney-absolute|organ weight-kidney-relative to body weight|in life observation-clinical signs-respiration (dyspnea)|in life observation-clinical signs-scabbing|pathology microscopic-kidney-necrosis|pathology microscopic-skin-acanthosis; dose_level=3; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_2 week study_Dermal_Rats; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =630 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 day to 14 day | SAC | study_id=5319; toxval_study_source_id=studyid5319_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-cytologic alterations|pathology microscopic-skin-ulcer|in life observation-clinical signs-scabbing|organ weight-liver-relative to body weight|in life observation-clinical signs-skin ulceration|pathology microscopic-skin-inflammation|pathology microscopic-skin-acanthosis|organ weight-liver-absolute|in life observation-mortality-mortality; dose_level=3; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water_2 week study_Dermal_Mice; dsstox_substance_id=DTXSID3021932; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_Cal_OEHHA_REL_derivations 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Cal_OEHHA_REL_derivations | LOAEL | =15 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | LONG_REF=Gamer AO, Hellwig J, and Hildebrand B. 1993. Study of the prenatal toxicity of diethanolamin in rats after inhalation. BASF Project No. 31RO233/90010. Ludwigshafen, FRG: BASF; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Chronic inflammation and squamous hyperplasia and metaplasia of the larynx; STUDY_GROUP=Cal OEHHA REL derivations:15952040:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_930e2caff1314a189d213b21a35ffaed |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =68801.7 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15514449:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_117e883898a6346e646070bd9ba72cf0 |
ToxValDB_EPA_TSCA_8e 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_TSCA_8e | LEL | =32 | mg/kg bw/day | Rat | dermal | chronic; 2 years | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88970000174_111422_3151EDD59E99671085256930004F3252.pdf; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=reduced weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EPA TSCA 8e:15957062:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5da827e988348456c5b607f3417b2b8e |
| ToxValDB_EPA_TSCA_8e | LEL | =40 | mg/kg bw/day | Mouse | dermal | chronic; 2 years | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88970000174_111422_3151EDD59E99671085256930004F3252.pdf; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=decreased body weight, decreased survival, increased incidence of hepatocellular adenoma, increased incidence of hepatocellular carcinoma, increased incidence of hepatoblastoma, increased incidence of renal tubule adenoma; STUDY_GROUP=EPA TSCA 8e:15957064:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0d43698dbd6f8c9c25dc4cfab25fbb02 |
| ToxValDB_EPA_TSCA_8e | LEL | =80 | mg/kg bw/day | Mouse | dermal | chronic; 2 years | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88970000174_111422_3151EDD59E99671085256930004F3252.pdf; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=decreased body weight, decreased survival; STUDY_GROUP=EPA TSCA 8e_dup_-_15957065_15957066:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_428008437f804e1ebb46404479ca74ee |
| ToxValDB_EPA_TSCA_8e | LEL | =300 | ppm | Rat | oral | - | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20984_Combined.pdf; TOXICOLOGICAL_EFFECT=P0: systemic toxicity, neurological toxicity; STUDY_GROUP=EPA TSCA 8e_dup_-_15957170_15957171_15957172:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6abc2aee4ac7feada31d461995f51f49 |
| ToxValDB_EPA_TSCA_8e | LEL | =100 | ppm | Rat | oral | - | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20984_Combined.pdf; TOXICOLOGICAL_EFFECT=F1: decreased thyroid hormone levels; STUDY_GROUP=EPA TSCA 8e_dup_-_15957170_15957171_15957172:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3add770b403d25ba13fbfcf81f44b176 |
| ToxValDB_EPA_TSCA_8e | NEL | =34 | mg/kg bw/day | Rat | dermal | chronic; 2 years | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88970000174_111422_3151EDD59E99671085256930004F3252.pdf; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=no effects on survival; STUDY_GROUP=EPA TSCA 8e:15957063:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6bba3683f458828733c3ce1157ede54e |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =0.5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632779_15632780:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_02b84a2ca155d8ccd68051525dae6c7d |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =0.75 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632779_15632780:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0e5b463fcd0df8f8a799eff9766760c6 |
ToxValDB_HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HESS | NOEL | <24.32 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e16e4b0a676289df6db; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Deaths|Clinical Observation: Tremors Emaciation Abnormal posture Rough fur|Body Weight Changes: decrease|Water Consumption: decrease|Urinalysis: TP increase, LDH increasep H increase|Hematology: MCV decrease, MCH decrease, Hct decrease, Hgb decrease, RBC decrease, MCHC increase, Ret decrease, WBC decrease, Seg decrease, Lymph decrease|Blood Chemistry: TP increase, Bile acid increase, Alb increase, BUN increase|Absolute Organ Weight: Rightkidney increase, Liver increase, Right testis decrease, Epididymis decrease|Relative Organ Weight: Rightkidney increase, Liver increase, Right testis decrease, Epididymis decrease|Histopathology: Rightkidney-Nephropathy Rightkidney-Tubular epithelial necrosis Rightkidney-Tubular mineralization Brain, medulla-Demyelination Spinal cord-Demyelination Epididymis-Seminiferous epithelium degeneration Testicular-degenerationadrenal cortex-Cytoplasmic vacuolization|Reproductive Tissue Evaluation: Spermatozoal measurements-Motility decrease, Spermatozoal measurements-Concentration decrease; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|mortality/survival|nonneoplastic histopathology|organ weight|reproduction|urinalysis; STUDY_GROUP=HESS:15638485:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c6eb3968e40c4cd90be9719c735c9fc0 |
ToxValDB_PPRTV_(CPHEA) 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_PPRTV_(CPHEA) | BMCL (10 HEC) | =0.63 | mg/m3 | Rat | inhalation | chronic; 99 days | chronic | LONG_REF=Gamer et al. 2008c; AUTHOR=Gamer et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1693; TOXICOLOGICAL_EFFECT=increased incidence of squamous metaplasia (level 1) (males); STUDY_GROUP=PPRTV (CPHEA):15653532:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bac2de5e03a44a5d8825ab2af710d982 |
| ToxValDB_PPRTV_(CPHEA) | BMDL (1SD) | =6.85 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP 1992a; AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1693; TOXICOLOGICAL_EFFECT=reduced relative kidney weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=PPRTV (CPHEA):15653860:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b8e0ad60d8eaa13ad00d467446fbd48b |
| ToxValDB_PPRTV_(CPHEA) | RfC (provisional) | =0.002 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Gamer et al. 2008c; AUTHOR=Gamer et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1693; TOXICOLOGICAL_EFFECT=Increase incidence of squamous metaplasia (level 1) in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653530_15653531:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_afdc1399f38c39d3a8d090df7602f92b |
| ToxValDB_PPRTV_(CPHEA) | RfD (provisional) | =0.02 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=NTP 1992a; AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1693; TOXICOLOGICAL_EFFECT=Significant reduction in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653339_15653486:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_457d666335813f0543011f0f7a5a8094 |
ToxValDB_Pennsylvania_DEP_ToxValues 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Pennsylvania_DEP_ToxValues | RfC | =0.0002 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650053:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c521e349fc7cc1ff38fce1227eff679 |
| ToxValDB_Pennsylvania_DEP_ToxValues | RfD | =0.002 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650052:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3512f298bb3d66eb7a5d86f9d524096e |
ToxValDB_TX_TCEQ 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_TX_TCEQ | BMDL (10 HEC) | =12.9 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | LONG_REF=Gamer, A.O., Rossbacher, R., Kaufmann, W. and van Ravenzwaay, B. 2008. The inhalation toxicity of di- and triethanolamine upon repeated exposure. Food and Chemical Toxicology. 46: 2173-2183; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b1b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/dea-tea.pdf; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=Increased relative liver weight in female rats.; STUDY_GROUP=TX TCEQ:15954406:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b833d5936cd82ce9a0439a2edef9b908 |
ToxValDB_ToxRefDB 26 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =79 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5308; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-reticulocyte-reticulocyte|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-kidney-absolute|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: in life observation-water consumption-water consumption|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-body weight-body weight gain|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: urinalysis-protein-protein|systemic: urinalysis-[other]-[other]|systemic: pathology microscopic-kidney-necrosis|systemic: urinalysis-glucose-glucose|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-clinical signs-tremors|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-reduced activity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708935_15708936_15708937:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_93892f9bf462c35d558035dd05e3e9c1 |
| ToxValDB_ToxRefDB | LEL | =77 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5308; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-reticulocyte-reticulocyte|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: urinalysis-[other]-[other]|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-tremors|systemic: urinalysis-glucose-glucose|systemic: urinalysis-protein-protein|systemic: pathology gross-testes-reduced size|systemic: pathology microscopic-testes-degeneration|systemic: pathology microscopic-kidney-necrosis|systemic: pathology microscopic-epididymis-cellular alteration|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-reduced activity|systemic: pathology microscopic-epididymis-oligospermia|systemic: in life observation-clinical signs-abnormal posture; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708938_15708939_15708940:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7736f9e1a60df28c45b45d1659602eb0 |
| ToxValDB_ToxRefDB | LEL | =326 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5311; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-cytologic alterations|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-heart-degeneration|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708941_15708942_15708943_15708944:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2a3906400a6c8974a0a944462e17461f |
| ToxValDB_ToxRefDB | LEL | =205 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5311; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-cytologic alterations|systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute|systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-heart-degeneration|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708945_15708946_15708947_15708948:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af46555bc95f8a7a9dcd77de7d95df62 |
| ToxValDB_ToxRefDB | LEL | =14 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water (13-week study in rats). Toxicity Report Series No. 20.; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water (13-week study in rats); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5314; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-kidney-mineralization|systemic: organ weight-kidney-absolute|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: pathology microscopic-kidney-nephropathy|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: clinical chemistry-bile acids-bile acids|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-reticulocyte-reticulocyte|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: organ weight-kidney-relative to body weight|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: pathology microscopic-spinal cord-demyelination|systemic: pathology microscopic-adrenal gland-vacuolization cytoplasmic|systemic: pathology microscopic-kidney-necrosis|systemic: in life observation-clinical signs-tremors|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-clinical signs-emaciation|systemic: pathology microscopic-brain-demyelination|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708949_15708950:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3bdf49e1807f9704c638f386898d5b02 |
| ToxValDB_ToxRefDB | LEL | =25 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water (13-week study in rats). Toxicity Report Series No. 20.; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically and in drinking water (13-week study in rats); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5314; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: organ weight-kidney-relative to body weight|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: organ weight-epididymis-relative to body weight|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: in life observation-water consumption-water consumption|systemic: clinical chemistry-bile acids-bile acids|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: organ weight-liver-relative to body weight|systemic: in life observation-body weight-body weight|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: pathology microscopic-kidney-mineralization|systemic: pathology gross-testes-reduced size|systemic: organ weight-testes-absolute|systemic: pathology microscopic-epididymis-hypospermia|systemic: pathology microscopic-epididymis-degeneration|systemic: organ weight-epididymis-absolute|systemic: pathology microscopic-testes-reduced spermatogenesis|systemic: pathology microscopic-brain-demyelination|systemic: pathology microscopic-prostate-atrophy|systemic: hematology-reticulocyte-reticulocyte|systemic: in life observation-clinical signs-emaciation|systemic: pathology gross-sperm measure-sperm count|systemic: in life observation-clinical signs-abnormal posture|systemic: pathology microscopic-spinal cord-demyelination|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: pathology microscopic-seminal vesicle-atrophy|systemic: pathology microscopic-testes-degeneration|systemic: pathology gross-sperm measure-sperm motility|systemic: pathology microscopic-epididymis-congestion|systemic: in life observation-clinical signs-tremors|systemic: organ weight-testes-relative to body weight|systemic: pathology microscopic-kidney-necrosis|systemic: pathology microscopic-adrenal gland-vacuolization cytoplasmic|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-kidney-nephropathy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ToxRefDB:15708951:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5d03c21d34f5d95a9a92be0a7aa98c42 |
| ToxValDB_ToxRefDB | LEL | =142 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_13 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_13 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5316; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: pathology microscopic-liver-cytologic alterations|systemic: organ weight-liver-relative to body weight|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: pathology microscopic-liver-necrosis|systemic: in life observation-body weight-body weight gain|systemic: organ weight-heart-relative to body weight|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-clinical signs-emaciation|systemic: pathology microscopic-kidney-nephropathy|systemic: organ weight-heart-absolute|systemic: in life observation-clinical signs-reduced activity|systemic: in life observation-clinical signs-tremors|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: pathology microscopic-heart-degeneration|systemic: pathology microscopic-salivary glands-[other]|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-kidney-necrosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708952_15708953:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e770e626a0480fbdba057c4573666938 |
| ToxValDB_ToxRefDB | LEL | =104 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_13 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_13 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5316; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-kidney-nephropathy|systemic: pathology microscopic-liver-cytologic alterations|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight|systemic: pathology microscopic-salivary glands-[other]|systemic: pathology microscopic-liver-necrosis|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-body weight-body weight gain|systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-clinical signs-reduced activity|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: in life observation-clinical signs-tremors|systemic: organ weight-heart-relative to body weight|systemic: pathology microscopic-heart-degeneration|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-kidney-necrosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708954_15708955:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a52c30df9849731414b36cde7231092 |
| ToxValDB_ToxRefDB | LEL | =125 | mg/kg bw/day | Rat | dermal | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5317; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-absolute|systemic: pathology microscopic-skin-hyperplasia|systemic: organ weight-kidney-relative to body weight|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: pathology microscopic-skin-acanthosis|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: pathology microscopic-skin-ulcer|systemic: pathology microscopic-skin-inflammation|systemic: in life observation-clinical signs-respiration (dyspnea)|systemic: pathology microscopic-kidney-necrosis|systemic: in life observation-clinical signs-scabbing|systemic: urinalysis-[other]-[other]|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-clinical signs-reduced activity|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708956_15708957_15708958:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3b9d49a6f12b0ae43279c3b35014de56 |
| ToxValDB_ToxRefDB | LEL | =160 | mg/kg bw/day | Mouse | dermal | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5319; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-acanthosis|systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute|systemic: in life observation-clinical signs-skin ulceration|systemic: pathology microscopic-liver-cytologic alterations|systemic: pathology microscopic-skin-inflammation|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-skin-ulcer|systemic: in life observation-clinical signs-scabbing; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708962_15708963_15708964:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d3f828f6afb19dd284bbaa6abee5bcf |
| ToxValDB_ToxRefDB | LEL | =32 | mg/kg bw/day | Rat | dermal | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_13 week study_Dermal_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_13 week study_Dermal_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5320; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-hyperkeratosis|systemic: hematology-reticulocyte-reticulocyte|systemic: organ weight-liver-absolute|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology microscopic-kidney-nephropathy|systemic: organ weight-kidney-relative to body weight|systemic: pathology microscopic-kidney-mineralization|systemic: organ weight-liver-relative to body weight|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: organ weight-kidney-absolute|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: pathology microscopic-skin-acanthosis|systemic: in life observation-clinical signs-scabbing|systemic: pathology microscopic-skin-inflammation|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-skin-ulcer|systemic: pathology microscopic-kidney-necrosis|systemic: pathology microscopic-brain-demyelination|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708968_15708969:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b698e6b9b7ca8d6694dc1870e204ee0d |
| ToxValDB_ToxRefDB | LEL | =80 | mg/kg bw/day | Mouse | dermal | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_13 week study_Dermal_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_13 week study_Dermal_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5322; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-skin-acanthosis|systemic: organ weight-kidney-absolute|systemic: organ weight-liver-absolute|systemic: pathology microscopic-liver-cytologic alterations|systemic: pathology microscopic-skin-inflammation|systemic: pathology gross-skin-thickened|systemic: pathology microscopic-skin-ulcer|systemic: in life observation-clinical signs-scabbing|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-heart-absolute|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-kidney-necrosis|systemic: pathology microscopic-salivary glands-cellular alteration|systemic: organ weight-heart-relative to body weight|systemic: pathology microscopic-skin-hyperkeratosis|systemic: pathology microscopic-heart-degeneration; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB:15708972:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a921380225503c8160817bd2a5608509 |
| ToxValDB_ToxRefDB | LEL | =8 | mg/kg bw/day | Rat | dermal | chronic; 103 weeks | chronic | LONG_REF=NTP_1999_Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies)_Rats; TITLE=Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies)_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5327; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-kidney-nephropathy|systemic: pathology microscopic-skin-exudate|systemic: pathology microscopic-skin-hyperkeratosis|systemic: pathology microscopic-skin-acanthosis|systemic: in life observation-clinical signs-skin ulceration|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708975_15708976:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6717b86a6da715ae92e6d134f5852a40 |
| ToxValDB_ToxRefDB | LEL | =16 | mg/kg bw/day | Rat | dermal | chronic; 103 weeks | chronic | LONG_REF=NTP_1999_Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies)_Rats; TITLE=Toxicology and carcinogenesis studies of diethanolamine (CAS No. 111-42-2) in F344/N rats and B6C3F1 mice (dermal studies)_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5327; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-hyperkeratosis|systemic: pathology microscopic-skin-acanthosis|systemic: pathology microscopic-skin-exudate|systemic: in life observation-clinical signs-skin ulceration|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15708977_15708978:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_841efae1430af89999a667b045f02828 |
| ToxValDB_ToxRefDB | LOAEL | =371 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5308; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: urinalysis-protein-protein|systemic: urinalysis-[other]-[other]|systemic: in life observation-body weight-body weight gain|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: pathology microscopic-kidney-necrosis|systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight|systemic: urinalysis-glucose-glucose; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708935_15708936_15708937:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_06754d6fdc858edadf05aa58840c7eee |
| ToxValDB_ToxRefDB | LOAEL | =319 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5308; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh); TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708938_15708939_15708940:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3fb1eb17086b171b549475e3354bedd8 |
| ToxValDB_ToxRefDB | LOAEL | =793 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5311; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708941_15708942_15708943_15708944:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_30287f8b0901f7468cc3f1ffeb29f93d |
| ToxValDB_ToxRefDB | LOAEL | =415 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5311; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute|systemic: pathology microscopic-liver-cytologic alterations; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708945_15708946_15708947_15708948:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a965555c557d793985cce7ac079ddb48 |
| ToxValDB_ToxRefDB | LOAEL | =1000 | mg/kg bw/day | Rat | dermal | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5317; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-respiration (dyspnea)|systemic: pathology microscopic-kidney-necrosis|systemic: organ weight-kidney-absolute|systemic: urinalysis-[other]-[other]|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-clinical signs-reduced activity; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708956_15708957_15708958:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_81eb0bef0963607329cc2513480ef45c |
| ToxValDB_ToxRefDB | LOAEL | =1250 | mg/kg bw/day | Mouse | dermal | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5319; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-acanthosis; STUDY_GROUP=ToxRefDB_dup_-_15708962_15708963_15708964:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_59626ba07eb4c67afe185e7f52f86fc5 |
| ToxValDB_ToxRefDB | NEL | =197 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5311; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: pathology microscopic-liver-cytologic alterations|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: pathology microscopic-heart-degeneration|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-abnormal posture|systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708941_15708942_15708943_15708944:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f0ae7074d3652e8a15250b8c24ff7dd1 |
| ToxValDB_ToxRefDB | NEL | =110 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5311; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-cytologic alterations|systemic: in life observation-water consumption-water consumption|systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-emaciation|systemic: pathology microscopic-heart-degeneration|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-clinical signs-fur (altered appearance); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708945_15708946_15708947_15708948:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_560cba5881c56fc4a4b5a9160b11213b |
| ToxValDB_ToxRefDB | NOAEL | =158 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5308; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-absolute|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: organ weight-kidney-relative to body weight|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-reticulocyte-reticulocyte|systemic: in life observation-clinical signs-tremors|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: in life observation-clinical signs-abnormal posture|systemic: urinalysis-glucose-glucose|systemic: in life observation-clinical signs-reduced activity|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: urinalysis-protein-protein|systemic: in life observation-body weight-body weight gain|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: urinalysis-[other]-[other]|systemic: in life observation-water consumption-water consumption|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-kidney-necrosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708935_15708936_15708937:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_84c4467504e7ab1aced7f9efb5c60f42 |
| ToxValDB_ToxRefDB | NOAEL | =162 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water to F344/N Rats and B6C3F1 Mice_2 week study_DW_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5308; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-kidney-necrosis|systemic: organ weight-kidney-absolute|systemic: pathology microscopic-testes-degeneration|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-reduced activity|systemic: hematology-reticulocyte-reticulocyte|systemic: pathology microscopic-epididymis-cellular alteration|systemic: in life observation-water consumption-water consumption|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology microscopic-epididymis-oligospermia|systemic: in life observation-clinical signs-abnormal posture|systemic: organ weight-kidney-relative to body weight|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: urinalysis-glucose-glucose|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: urinalysis-protein-protein|systemic: pathology gross-testes-reduced size|systemic: in life observation-clinical signs-tremors|systemic: urinalysis-[other]-[other]; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708938_15708939_15708940:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ec43e730ce757f110b6d87a68f7d79b7 |
| ToxValDB_ToxRefDB | NOAEL | =500 | mg/kg bw/day | Rat | dermal | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Rats; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5317; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-absolute|systemic: urinalysis-lactic acid dehydrogenase (ldh)-lactic acid dehydrogenase (ldh)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: urinalysis-[other]-[other]|systemic: pathology microscopic-skin-hyperplasia|systemic: in life observation-body weight-body weight gain|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-clinical signs-emaciation|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: in life observation-clinical signs-reduced activity|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: pathology microscopic-skin-ulcer|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-respiration (dyspnea)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: in life observation-clinical signs-scabbing|systemic: pathology microscopic-kidney-necrosis|systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-skin-acanthosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15708956_15708957_15708958:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3c4dc5d2527eb6e0b12db4c3470f9010 |
| ToxValDB_ToxRefDB | NOAEL | =630 | mg/kg bw/day | Mouse | dermal | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Mice; TITLE=Technical report on the toxicity studies of Diethanolamine (CAS No. 111-42-2) administered topically & in drinking water_2 week study_Dermal_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5319; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-ulcer|systemic: in life observation-clinical signs-scabbing|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-skin-acanthosis|systemic: in life observation-clinical signs-skin ulceration|systemic: pathology microscopic-liver-cytologic alterations|systemic: organ weight-liver-absolute|systemic: pathology microscopic-skin-inflammation|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708962_15708963_15708964:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_09f942c67ec8e6041d7958c861c2b28a |
UnifiedCodex:CIR:beta.noael_studies 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| UnifiedCodex:CIR:beta.noael_studies | - | 250 | mg/kg | rat | - | 5 d | - | SOURCE_SUBDIR=PRS575; REPORT_TITLE=New Safety Assessment Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3,; OPINION_NUMBER=PRS575; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=1 In 2010; VALUE_TEXT=250; 500; DOSE=, 250, and 500 mg/kg bw/d diethanolamine (purity >99%) in 95% ethanol were applied to the backs of 10 male and 10 female F344/N rats, 5 d/wk for 13 weeks.35 Vehicle only was applied to the negative control group.; EFFECT=, 250, and 500 mg/kg bw/d diethanolamine (purity >99%) in 95% ethanol were applied to the backs of 10 male and 10 female F344/N rats, 5 d/wk for 13 weeks.35 Vehicle only was applied to the negative control group. (The square area of the dose site was not provided.) One male and 2 females given 500 mg/kg died or were killed in moribund condition during the study. Clinical signs of toxicity, observed in males and females given 125 to 500 mg/kg diethanolamine, were irritation and crusting at the application site. The no observable adverse effect level (NOAEL) for ulceration was 125 mg/kg for male rats and 63 mg/kg for female rats. Final mean bws were statistically sig- nificantly decreased in males dosed with 250 and 500 mg/kg and females dosed with 125 to 500 mg/kg diethanolamine. Increases in absolute and relative kidney weights were observed with increased incidence of renal lesions. Nephropa- thy was observed in lower and mid-dose females, but a clear treatment effect was not seen in males. Increases in absolute and relative liver weights were not accompanied by an increase in he...; CITATION=250; 500; 99; CITATION_NUMBERS=[250,500,99]; REFERENCE=250; 500; 99; DETAILS_JSON={"cas_number":"111-42-2","citation":"250; 500; 99","dose":", 250, and 500 mg/kg bw/d diethanolamine (purity >99%) in 95% ethanol were applied to the backs of 10 male and 10 female F344/N rats, 5 d/wk for 13 weeks.35 Vehicle only was applied to the negative control group.","duration":"5 d","effect":", 250, and 500 mg/kg bw/d diethanolamine (purity >99%) in 95% ethanol were applied to the backs of 10 male and 10 female F344/N rats, 5 d/wk for 13 weeks.35 Vehicle only was applied to the negative control group. (The square area of the dose site was not provided.) One male and 2 females given 500 mg/kg died or were killed in moribund condition during the study. Clinical signs of toxicity, observed in males and females given 125 to 500 mg/kg diethanolamine, were irritation and crusting at the application site. The no observable adverse effect level (NOAEL) for ulceration was 125 mg/kg for male rats and 63 mg/kg for female rats. Final mean bws were statistically sig- nificantly decreased in males dosed with 250 and 500 mg/kg and females dosed with 125 to 500 mg/kg diethanolamine. Increases in absolute and relative kidney weights were observed with increased incidence of renal lesions. Nephropa- thy was observed in lower and mid-dose females, but a clear treatment effect was not seen in males. Increases in absolute and relative liver weights were not accompanied by an increase in he...","endpoint":"","ingredient":"New Safety Assessment Safety Assessment of Diethanolamine and Its Salts","loael_value":"","noael_unit":"mg/kg","noael_value":"250; 500","page":11,"route":"","species":"rat","study_id":"PRS575_noael_001"} |
| UnifiedCodex:CIR:beta.noael_studies | - | 10 | mg/kg/d | mouse | dermal | 4 weeks | - | SOURCE_SUBDIR=PRS575; REPORT_TITLE=New Safety Assessment Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3,; OPINION_NUMBER=PRS575; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=1 In 2010; VALUE_TEXT=10; DOSE=The dose–response, reversibility, and strain dependence of diethanolamine effects on hepatic choline deficiency were studied.74 B6C3F1 mice were dosed dermally with diethanolamine in ethanol for 4 weeks.; EFFECT=were seen without fatty livers, an observation often associated with cho- line deficiency. The dose–response, reversibility, and strain dependence of diethanolamine effects on hepatic choline deficiency were studied.74 B6C3F1 mice were dosed dermally with diethanolamine in ethanol for 4 weeks. Control animals were either not dosed or dosed with ethanol only. The pat- tern of changes observed in choline metabolites after dietha- nolamine treatment was very similar to that observed in choline-deficient mice, and the NOEL for diethanolamine- induced changes in choline homeostasis was 10 mg/kg/d. Fatty livers were not observed. The reactions were dose dependent and reversible. Strain dependency was evaluated by dosing male C57BL/6 mice with 0 or 160 mg diethano- lamine/kg bw for a similar 4-week period. Hepatic choline deficiency was found to be strain dependent. Dermal appli- cation of 95% ethanol decreased hepatic betaine levels, sug- gesting that the use of ethanol as a vehicle for dermal application of diethanolamine could exacerbate the bio- chemical effects of diethanolamine. Oc...; CITATION=74; 4; 10; CITATION_NUMBERS=[74,4,10]; REFERENCE=74; 4; 10; DETAILS_JSON={"cas_number":"111-42-2","citation":"74; 4; 10","dose":"The dose–response, reversibility, and strain dependence of diethanolamine effects on hepatic choline deficiency were studied.74 B6C3F1 mice were dosed dermally with diethanolamine in ethanol for 4 weeks.","duration":"4 weeks","effect":"were seen without fatty livers, an observation often associated with cho- line deficiency. The dose–response, reversibility, and strain dependence of diethanolamine effects on hepatic choline deficiency were studied.74 B6C3F1 mice were dosed dermally with diethanolamine in ethanol for 4 weeks. Control animals were either not dosed or dosed with ethanol only. The pat- tern of changes observed in choline metabolites after dietha- nolamine treatment was very similar to that observed in choline-deficient mice, and the NOEL for diethanolamine- induced changes in choline homeostasis was 10 mg/kg/d. Fatty livers were not observed. The reactions were dose dependent and reversible. Strain dependency was evaluated by dosing male C57BL/6 mice with 0 or 160 mg diethano- lamine/kg bw for a similar 4-week period. Hepatic choline deficiency was found to be strain dependent. Dermal appli- cation of 95% ethanol decreased hepatic betaine levels, sug- gesting that the use of ethanol as a vehicle for dermal application of diethanolamine could exacerbate the bio- chemical effects of diethanolamine. Oc...","endpoint":"","ingredient":"New Safety Assessment Safety Assessment of Diethanolamine and Its Salts","loael_value":"","noael_unit":"mg/kg/d","noael_value":"10","page":17,"route":"dermal","species":"mouse","study_id":"PRS575_noael_009"} |
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 380 | mg/kg/d | rabbit | dermal | - | developmental toxicity | SOURCE_SUBDIR=PRS575; REPORT_TITLE=New Safety Assessment Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3,; OPINION_NUMBER=PRS575; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=1 In 2010; VALUE_TEXT=380; DOSE=ere dosed dermally with 150, 500, or 1,500 mg/kg/d dietha- nolamine in deionized water, 6 h/d, on days 6 to 15 of gestation, under an occlusive covering.; EFFECT=ere dosed dermally with 150, 500, or 1,500 mg/kg/d dietha- nolamine in deionized water, 6 h/d, on days 6 to 15 of gestation, under an occlusive covering. Dosing volume was 4 mL/kg/d. Control animals were dosed with vehicle only. Teratogenic effects were not seen at any dose. Dermal application of 500 mg/kg diethanolamine resulted in alterations in maternal hema- tological parameters but did not affect embryonal/fetal devel- opment. Other signs of maternal toxicity were seen at this dose and with 1,500 mg/kg/d. The NOEL for embryonal/fetal toxi- city was estimated to be 380 mg/kg/d, which incorporates an adjustment for the 10% to 24% deficit in expected dose that occurred on days 12 to 15 of gestation. Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were obs...; CITATION=150, 500; 1,500; 6; CITATION_NUMBERS=[150,500,1,6]; REFERENCE=150, 500; 1,500; 6; DETAILS_JSON={"cas_number":"111-42-2","citation":"150, 500; 1,500; 6","dose":"ere dosed dermally with 150, 500, or 1,500 mg/kg/d dietha- nolamine in deionized water, 6 h/d, on days 6 to 15 of gestation, under an occlusive covering.","duration":"","effect":"ere dosed dermally with 150, 500, or 1,500 mg/kg/d dietha- nolamine in deionized water, 6 h/d, on days 6 to 15 of gestation, under an occlusive covering. Dosing volume was 4 mL/kg/d. Control animals were dosed with vehicle only. Teratogenic effects were not seen at any dose. Dermal application of 500 mg/kg diethanolamine resulted in alterations in maternal hema- tological parameters but did not affect embryonal/fetal devel- opment. Other signs of maternal toxicity were seen at this dose and with 1,500 mg/kg/d. The NOEL for embryonal/fetal toxi- city was estimated to be 380 mg/kg/d, which incorporates an adjustment for the 10% to 24% deficit in expected dose that occurred on days 12 to 15 of gestation. Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were obs...","endpoint":"developmental toxicity","ingredient":"New Safety Assessment Safety Assessment of Diethanolamine and Its Salts","loael_value":"","noael_unit":"mg/kg/d","noael_value":"380","page":13,"route":"dermal","species":"rabbit","study_id":"PRS575_noael_004"} |
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 35 | mg/kg/d | mouse | oral | - | developmental toxicity | SOURCE_SUBDIR=PRS575; REPORT_TITLE=New Safety Assessment Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3,; OPINION_NUMBER=PRS575; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=1 In 2010; VALUE_TEXT=35; DOSE=Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering.; EFFECT=gestation. Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were observed at this dose. No developmental toxicity was observed, and there was no evidence of teratogeni- city at any dose. The NOEL for maternal toxicity of diethano- lamine in rabbits was 35 mg/kg/d, and the embryonal/fetal NOEL was 350 mg/kg/d diethanolamine. Oral In a Chernoff-Kavlock screening test, groups of 4 gravid CD-1 mice were dosed orally, by gavage, with 200, 380, 720, 1,370, or 2,605 mg/kg bw diethanolamine in distilled water on days 6 to 15 of gestation; a control group was dosed with vehicle only.36 Two, 3, and 4 of 4 animals of the 720, 1,370, and 2,605 mg/kg dose groups died during the study. Rough hair coats were observed at all dose levels. Group of 50 female gravid CD-1 femal...; CITATION=15; 35, 100; 350; CITATION_NUMBERS=[15,35,100,350]; REFERENCE=15; 35, 100; 350; DETAILS_JSON={"cas_number":"111-42-2","citation":"15; 35, 100; 350","dose":"Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering.","duration":"","effect":"gestation. Groups of 15 mated rabbits were dosed dermally with 35, 100, or 350 mg/kg/d diethanolamine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were observed at this dose. No developmental toxicity was observed, and there was no evidence of teratogeni- city at any dose. The NOEL for maternal toxicity of diethano- lamine in rabbits was 35 mg/kg/d, and the embryonal/fetal NOEL was 350 mg/kg/d diethanolamine. Oral In a Chernoff-Kavlock screening test, groups of 4 gravid CD-1 mice were dosed orally, by gavage, with 200, 380, 720, 1,370, or 2,605 mg/kg bw diethanolamine in distilled water on days 6 to 15 of gestation; a control group was dosed with vehicle only.36 Two, 3, and 4 of 4 animals of the 720, 1,370, and 2,605 mg/kg dose groups died during the study. Rough hair coats were observed at all dose levels. Group of 50 female gravid CD-1 femal...","endpoint":"developmental toxicity","ingredient":"New Safety Assessment Safety Assessment of Diethanolamine and Its Salts","loael_value":"","noael_unit":"mg/kg/d","noael_value":"35","page":13,"route":"oral","species":"mouse","study_id":"PRS575_noael_005"} |
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 350 | mg/kg/d | mouse | oral | - | developmental toxicity | SOURCE_SUBDIR=PRS575; REPORT_TITLE=New Safety Assessment Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3,; OPINION_NUMBER=PRS575; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=1 In 2010; VALUE_TEXT=350; DOSE=Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only.; EFFECT=ine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were observed at this dose. No developmental toxicity was observed, and there was no evidence of teratogeni- city at any dose. The NOEL for maternal toxicity of diethano- lamine in rabbits was 35 mg/kg/d, and the embryonal/fetal NOEL was 350 mg/kg/d diethanolamine. Oral In a Chernoff-Kavlock screening test, groups of 4 gravid CD-1 mice were dosed orally, by gavage, with 200, 380, 720, 1,370, or 2,605 mg/kg bw diethanolamine in distilled water on days 6 to 15 of gestation; a control group was dosed with vehicle only.36 Two, 3, and 4 of 4 animals of the 720, 1,370, and 2,605 mg/kg dose groups died during the study. Rough hair coats were observed at all dose levels. Group of 50 female gravid CD-1 female mice were dosed orally, by gavage, with 0 or 450 mg/kg bw diethanolamine in distilled water on d...; CITATION=6; 18; 2; CITATION_NUMBERS=[6,18,2]; REFERENCE=6; 18; 2; DETAILS_JSON={"cas_number":"111-42-2","citation":"6; 18; 2","dose":"Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only.","duration":"","effect":"ine in deionized water, 6 h/d, on days 6 to 18 of gestation, under an occlusive covering. Dosing volume was 2 mL/kg/d, and controls were dosed with vehicle only. Dermal administration of 350 mg/kg/d diethano- lamine produced severe skin irritation in rabbits, and signs of maternal toxicity were observed at this dose. No developmental toxicity was observed, and there was no evidence of teratogeni- city at any dose. The NOEL for maternal toxicity of diethano- lamine in rabbits was 35 mg/kg/d, and the embryonal/fetal NOEL was 350 mg/kg/d diethanolamine. Oral In a Chernoff-Kavlock screening test, groups of 4 gravid CD-1 mice were dosed orally, by gavage, with 200, 380, 720, 1,370, or 2,605 mg/kg bw diethanolamine in distilled water on days 6 to 15 of gestation; a control group was dosed with vehicle only.36 Two, 3, and 4 of 4 animals of the 720, 1,370, and 2,605 mg/kg dose groups died during the study. Rough hair coats were observed at all dose levels. Group of 50 female gravid CD-1 female mice were dosed orally, by gavage, with 0 or 450 mg/kg bw diethanolamine in distilled water on d...","endpoint":"developmental toxicity","ingredient":"New Safety Assessment Safety Assessment of Diethanolamine and Its Salts","loael_value":"","noael_unit":"mg/kg/d","noael_value":"350","page":13,"route":"oral","species":"mouse","study_id":"PRS575_noael_006"} |
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 50 | mg/kg/d | rat | oral | - | developmental toxicity | SOURCE_SUBDIR=PRS575; REPORT_TITLE=New Safety Assessment Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3,; OPINION_NUMBER=PRS575; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=1 In 2010; VALUE_TEXT=50 and 200; DOSE=Gravid Sprague Dawley rats were dosed orally, by gavage, with 50, 200, 500, 800, or 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation.44 Maternal mortality was observed at doses of 50 to 1200 mg/kg/d.; EFFECT=ber of live litters on day 0 were not affected by dosing, but the average number of live litters on day 3 was decreased. Mean bws and bw gains of pups were also decreased on PND 3. Gravid Sprague Dawley rats were dosed orally, by gavage, with 50, 200, 500, 800, or 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation.44 Maternal mortality was observed at doses of 50 to 1200 mg/kg/d. At doses of 50 and 200 mg/kg/d, no differences in gross developmental end points were found between test and control animals. The NOEL for embryonal/ Fiume et al 101S; CITATION=0; 3; 50, 200, 500, 800; CITATION_NUMBERS=[3,50,200,500,800]; REFERENCE=0; 3; 50, 200, 500, 800; DETAILS_JSON={"cas_number":"111-42-2","citation":"0; 3; 50, 200, 500, 800","dose":"Gravid Sprague Dawley rats were dosed orally, by gavage, with 50, 200, 500, 800, or 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation.44 Maternal mortality was observed at doses of 50 to 1200 mg/kg/d.","duration":"","effect":"ber of live litters on day 0 were not affected by dosing, but the average number of live litters on day 3 was decreased. Mean bws and bw gains of pups were also decreased on PND 3. Gravid Sprague Dawley rats were dosed orally, by gavage, with 50, 200, 500, 800, or 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation.44 Maternal mortality was observed at doses of 50 to 1200 mg/kg/d. At doses of 50 and 200 mg/kg/d, no differences in gross developmental end points were found between test and control animals. The NOEL for embryonal/ Fiume et al 101S","endpoint":"developmental toxicity","ingredient":"New Safety Assessment Safety Assessment of Diethanolamine and Its Salts","loael_value":"","noael_unit":"mg/kg/d","noael_value":"50 and 200","page":13,"route":"oral","species":"rat","study_id":"PRS575_noael_007"} |
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 50 | mg/kg/d | rat | inhalation | - | developmental toxicity | SOURCE_SUBDIR=PRS575; REPORT_TITLE=New Safety Assessment Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3,; OPINION_NUMBER=PRS575; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=1 In 2010; VALUE_TEXT=50; DOSE=ed for 1 dam dosed with 200 mg/kg, and only 5 dams of the 250 mg/kg group delivered live litters and survived until study termination.; LOAEL_VALUE=125 mg/kg/d; EFFECT=ed for 1 dam dosed with 200 mg/kg, and only 5 dams of the 250 mg/kg group delivered live litters and survived until study termination. The calculated LD50 was 218 mg/kg bw/d. No significant maternal or developmental toxicity was seen with 50 mg/kg bw/d diethanolamine. Signs of maternal and developmental toxicity were seen at doses of 125 mg/kg bw/d and included decreased maternal weight gains, increased kidney weights in dams, increased postimplan- tation and postnatal mortality, and reduced live pup weights. The NOAEL for maternal toxicity and teratogenicity was 50 mg/kg/d, and the lowest-observable-adverse-effect level (LOAEL) for these parameters was 125 mg/kg/d. Inhalation In a range-finding study, groups of 10 gravid Wistar rats were exposed, nose only, to target concentrations of 0.1, 0.2, or 0.4 mg /L diethanolamine, 6 h/d, on days 6 to 15 of gestation.46 (Diethanolamine purity was >98.7%.) All animals survived until study termination. Relative liver weights were increased in animals of the 0.2 mg/L group, and absolute and relative liver weights were increased in animals o...; CITATION=1; 200; 5; CITATION_NUMBERS=[1,200,5]; REFERENCE=1; 200; 5; DETAILS_JSON={"cas_number":"111-42-2","citation":"1; 200; 5","dose":"ed for 1 dam dosed with 200 mg/kg, and only 5 dams of the 250 mg/kg group delivered live litters and survived until study termination.","duration":"","effect":"ed for 1 dam dosed with 200 mg/kg, and only 5 dams of the 250 mg/kg group delivered live litters and survived until study termination. The calculated LD50 was 218 mg/kg bw/d. No significant maternal or developmental toxicity was seen with 50 mg/kg bw/d diethanolamine. Signs of maternal and developmental toxicity were seen at doses of \u0005125 mg/kg bw/d and included decreased maternal weight gains, increased kidney weights in dams, increased postimplan- tation and postnatal mortality, and reduced live pup weights. The NOAEL for maternal toxicity and teratogenicity was 50 mg/kg/d, and the lowest-observable-adverse-effect level (LOAEL) for these parameters was 125 mg/kg/d. Inhalation In a range-finding study, groups of 10 gravid Wistar rats were exposed, nose only, to target concentrations of 0.1, 0.2, or 0.4 mg /L diethanolamine, 6 h/d, on days 6 to 15 of gestation.46 (Diethanolamine purity was >98.7%.) All animals survived until study termination. Relative liver weights were increased in animals of the 0.2 mg/L group, and absolute and relative liver weights were increased in animals o...","endpoint":"developmental toxicity","ingredient":"New Safety Assessment Safety Assessment of Diethanolamine and Its Salts","loael_value":"125 mg/kg/d","noael_unit":"mg/kg/d","noael_value":"50","page":14,"route":"inhalation","species":"rat","study_id":"PRS575_noael_008"} |
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 200 | mg/kg/ d | rat | oral | - | developmental toxicity | SOURCE_SUBDIR=PRS575; REPORT_TITLE=New Safety Assessment Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3,; OPINION_NUMBER=PRS575; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=1 In 2010; VALUE_TEXT=200; DOSE=creased at all doses (20-320 mg/kg) in a dose-dependent manner.; LOAEL_VALUE=125 mg/kg/d; EFFECT=creased at all doses (20-320 mg/kg) in a dose-dependent manner. In rats and rabbits, dermal dosing with up to 1,500 mg/kg and 350 mg/kg diethanolamine, respectively, during gestation did not have any fetotoxic or teratogenic effects. The NOEL for embryonal/fetal toxicity was 380 mg/kg/d for rats and 350 mg/kg/d for rabbits. In an oral developmental toxicity study in which rats were dosed with up to 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation, maternal mortality was observed at doses of 50 mg/kg; the NOEL for embryonal/fetal toxicity was 200 mg/kg/ d. In a study in which gravid rats were dosed orally with up to 300 mg/kg/d diethanolamine, the dams of the 300 mg/kg group were killed due to excessive toxicity; the LD50 was calculated to be 218 mg/kg. The LOAEL for both maternal toxicity and teratogenicity was 125 mg/kg/d. In a developmental toxicity study in which rats were exposed by inhalation to diethanolamine on days 6 to 15 of gestation, the NOAEC for both maternal and developmental toxicity was 0.05 mg/L and the NOAEC for teratogenicity was >0.2 mg/L. Diethanolam...; CITATION=(20; 320; 1,500; CITATION_NUMBERS=[20,320,1,500]; REFERENCE=(20; 320; 1,500; DETAILS_JSON={"cas_number":"111-42-2","citation":"(20; 320; 1,500","dose":"creased at all doses (20-320 mg/kg) in a dose-dependent manner.","duration":"","effect":"creased at all doses (20-320 mg/kg) in a dose-dependent manner. In rats and rabbits, dermal dosing with up to 1,500 mg/kg and 350 mg/kg diethanolamine, respectively, during gestation did not have any fetotoxic or teratogenic effects. The NOEL for embryonal/fetal toxicity was 380 mg/kg/d for rats and 350 mg/kg/d for rabbits. In an oral developmental toxicity study in which rats were dosed with up to 1,200 mg/kg/d diethanolamine on days 6 to 15 of gestation, maternal mortality was observed at doses of \u000550 mg/kg; the NOEL for embryonal/fetal toxicity was 200 mg/kg/ d. In a study in which gravid rats were dosed orally with up to 300 mg/kg/d diethanolamine, the dams of the 300 mg/kg group were killed due to excessive toxicity; the LD50 was calculated to be 218 mg/kg. The LOAEL for both maternal toxicity and teratogenicity was 125 mg/kg/d. In a developmental toxicity study in which rats were exposed by inhalation to diethanolamine on days 6 to 15 of gestation, the NOAEC for both maternal and developmental toxicity was 0.05 mg/L and the NOAEC for teratogenicity was >0.2 mg/L. Diethanolam...","endpoint":"developmental toxicity","ingredient":"New Safety Assessment Safety Assessment of Diethanolamine and Its Salts","loael_value":"125 mg/kg/d","noael_unit":"mg/kg/ d","noael_value":"200","page":18,"route":"oral","species":"rat","study_id":"PRS575_noael_010"} |
| UnifiedCodex:CIR:beta.noael_studies | oral toxicity | 250 | mg/kg d | rat | oral | 7 weeks | oral toxicity | SOURCE_SUBDIR=PRS575; REPORT_TITLE=New Safety Assessment Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3,; OPINION_NUMBER=PRS575; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=1 In 2010; VALUE_TEXT=250; DOSE=ed with 125 to 500 mg/kg diethanolamine.; EFFECT=ed with 125 to 500 mg/kg diethanolamine. Increases in absolute and relative kidney weights were observed with increased incidence of renal lesions. Nephropa- thy was observed in lower and mid-dose females, but a clear treatment effect was not seen in males. Increases in absolute and relative liver weights were not accompanied by an increase in hepatic lesions. Demyelination in the medulla oblongata was seen in all high-dose animals (7 females) given 250 mg/kg diethanolamine; this lesion was minimal in severity. An NOAEL was not achieved regarding hematological changes, but the researchers did note that the differences between con- trols and male rats exposed to 32 mg/kg diethanolamine were minimal. Oral. A previous safety assessment of triethanolamine, dietha- nolamine, and monoethanolamine reported on oral studies con- ducted in which neonatal rats were dosed with 1 to 3 mM/kg/d diethanolamine, as a neutralized salt, on days 5 to 15 after birth, male rats were dosed with 4 mg/mL neutralized diethanolamine in drinking water for 7 weeks, and rats were fed 0 to 0.68 g/kg/d diethanol...; CITATION=125; 500; (7; CITATION_NUMBERS=[125,500,7]; REFERENCE=125; 500; (7; DETAILS_JSON={"cas_number":"111-42-2","citation":"125; 500; (7","dose":"ed with 125 to 500 mg/kg diethanolamine.","duration":"7 weeks","effect":"ed with 125 to 500 mg/kg diethanolamine. Increases in absolute and relative kidney weights were observed with increased incidence of renal lesions. Nephropa- thy was observed in lower and mid-dose females, but a clear treatment effect was not seen in males. Increases in absolute and relative liver weights were not accompanied by an increase in hepatic lesions. Demyelination in the medulla oblongata was seen in all high-dose animals (7 females) given 250 mg/kg diethanolamine; this lesion was minimal in severity. An NOAEL was not achieved regarding hematological changes, but the researchers did note that the differences between con- trols and male rats exposed to 32 mg/kg diethanolamine were minimal. Oral. A previous safety assessment of triethanolamine, dietha- nolamine, and monoethanolamine reported on oral studies con- ducted in which neonatal rats were dosed with 1 to 3 mM/kg/d diethanolamine, as a neutralized salt, on days 5 to 15 after birth, male rats were dosed with 4 mg/mL neutralized diethanolamine in drinking water for 7 weeks, and rats were fed 0 to 0.68 g/kg/d diethanol...","endpoint":"oral toxicity","ingredient":"New Safety Assessment Safety Assessment of Diethanolamine and Its Salts","loael_value":"","noael_unit":"mg/kg d","noael_value":"250","page":11,"route":"oral","species":"rat","study_id":"PRS575_noael_002"} |
| UnifiedCodex:CIR:beta.noael_studies | repeated dose toxicity | 1.5 | mg/m3 | rat | inhalation | 3 months | repeated dose toxicity | SOURCE_SUBDIR=PRS575; REPORT_TITLE=New Safety Assessment Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics Monice M. Fiume1, Bart Heldreth2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3,; OPINION_NUMBER=PRS575; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=1 In 2010; VALUE_TEXT=1.5; DOSE=et concentrations of 0, 1.5, 3, and 8 mg/m3 diethanolamine using the same dosing schedule as above, and recovery groups of 10 females were exposed to 3 or 8 mg/m3, with a postexposure period of 3 months.; EFFECT=et concentrations of 0, 1.5, 3, and 8 mg/m3 diethanolamine using the same dosing schedule as above, and recovery groups of 10 females were exposed to 3 or 8 mg/m3, with a postexposure period of 3 months. No dose- related clinical signs were observed. Liver weights of test, but not recovery, females dosed with 8 mg/m3 were statistically significantly increased. Laryngeal effects were similar to those described above. No microscopic changes were observed in the upper respiratory tract of recovery animals. The 90-day no observed effect concentration (NOAEC) was determined to be 1.5 mg/m3 diethanolamine. In inhalation studies, Sprague Dawley rats, Hartley guinea pigs, and beagle dogs (number per species and sex not speci- fied) were each exposed to 0.5 ppm diethanolamine for 6 h/d, 5 d/wk, for a total of 45 exposures.40 All animals survived until study termination. There were no clinical signs of toxicity and no evidence of irritation. No gross or microscopic lesions were observed at necropsy. Reproductive and Developmental Toxicity Dermal No developmental or reproductive effects were...; CITATION=0, 1; 5, 3; 8; CITATION_NUMBERS=[1,5,3,8]; REFERENCE=0, 1; 5, 3; 8; DETAILS_JSON={"cas_number":"111-42-2","citation":"0, 1; 5, 3; 8","dose":"et concentrations of 0, 1.5, 3, and 8 mg/m3 diethanolamine using the same dosing schedule as above, and recovery groups of 10 females were exposed to 3 or 8 mg/m3, with a postexposure period of 3 months.","duration":"3 months","effect":"et concentrations of 0, 1.5, 3, and 8 mg/m3 diethanolamine using the same dosing schedule as above, and recovery groups of 10 females were exposed to 3 or 8 mg/m3, with a postexposure period of 3 months. No dose- related clinical signs were observed. Liver weights of test, but not recovery, females dosed with 8 mg/m3 were statistically significantly increased. Laryngeal effects were similar to those described above. No microscopic changes were observed in the upper respiratory tract of recovery animals. The 90-day no observed effect concentration (NOAEC) was determined to be 1.5 mg/m3 diethanolamine. In inhalation studies, Sprague Dawley rats, Hartley guinea pigs, and beagle dogs (number per species and sex not speci- fied) were each exposed to 0.5 ppm diethanolamine for 6 h/d, 5 d/wk, for a total of 45 exposures.40 All animals survived until study termination. There were no clinical signs of toxicity and no evidence of irritation. No gross or microscopic lesions were observed at necropsy. Reproductive and Developmental Toxicity Dermal No developmental or reproductive effects were...","endpoint":"repeated dose toxicity","ingredient":"New Safety Assessment Safety Assessment of Diethanolamine and Its Salts","loael_value":"","noael_unit":"mg/m3","noael_value":"1.5","page":13,"route":"inhalation","species":"rat","study_id":"PRS575_noael_003"} |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | AZE05TDV2V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H11NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"AZE05TDV2V"} |
| openFDA substances | FDA UNII substance identifier | AZE05TDV2V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H11NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"AZE05TDV2V"} |
| openFDA substances | FDA UNII substance identifier | AZE05TDV2V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H11NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"AZE05TDV2V"} |
| openFDA substances | FDA UNII substance identifier | AZE05TDV2V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H11NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"AZE05TDV2V"} |