NOAEL Studies
Cosmetic Ingredient
Dichlorophene NOAEL Studies
INCI: DICHLOROPHENE
CAS: 97-23-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR Safety Assessment 32 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =1 | mg/kg/day | rabbit | dermal | 7-day | NOAEL study | {"citation":"72; 7; 6","dose":"The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study.","effect":"were replaced. Coriaceousness occurred at all intact and abraded sites from the 72-h reading through day 7. Sloughing occurred in three abraded sites at the 6- and 7-day scorings. Edema was present at all intact and abraded sites throughout the study. The primary irritation index (PII) was 6.3 (Hill Top Research, Inc. 1980a). The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study. The NOEL for systemic effects was 25 mg/kg/day. The NOEL for skin effects was 1 mg/kg/day, whereas the LOEL for skin effects, based on acanthosis, hyper- keratosis, parakeratosis, dermatitis, and scabs, was 5 mg/kg/day. Dermal Sensitization Dichlorophene In a skin irritation and sensitization test reported by Haskell Laboratories(1950),Dichloropheneproducedminimalirritation when applied to the backs of 10 shaved guinea pigs. None of the guinea pigs had an allergic skin sensitization reaction. NIOSH (1980) performed a skin sensitization study using the samepatchmethodasfortheirdermalirritationstudiesdescribed earlier. The...","page":15,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_004"} |
| CIR Safety Assessment | NOAEL | =1 | mg/kg/day | rabbit | dermal | 7-day | NOAEL study | {"citation":"72; 7; 6","dose":"The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study.","effect":"were replaced. Coriaceousness occurred at all intact and abraded sites from the 72-h reading through day 7. Sloughing occurred in three abraded sites at the 6- and 7-day scorings. Edema was present at all intact and abraded sites throughout the study. The primary irritation index (PII) was 6.3 (Hill Top Research, Inc. 1980a). The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study. The NOEL for systemic effects was 25 mg/kg/day. The NOEL for skin effects was 1 mg/kg/day, whereas the LOEL for skin effects, based on acanthosis, hyper- keratosis, parakeratosis, dermatitis, and scabs, was 5 mg/kg/day. Dermal Sensitization Dichlorophene In a skin irritation and sensitization test reported by Haskell Laboratories(1950),Dichloropheneproducedminimalirritation when applied to the backs of 10 shaved guinea pigs. None of the guinea pigs had an allergic skin sensitization reaction. NIOSH (1980) performed a skin sensitization study using the samepatchmethodasfortheirdermalirritationstudiesdescribed earlier. The...","page":15,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_004"} |
| CIR Safety Assessment | NOAEL | =1 | mg/kg/day | rabbit | dermal | 7-day | NOAEL study | {"citation":"72; 7; 6","dose":"The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study.","effect":"were replaced. Coriaceousness occurred at all intact and abraded sites from the 72-h reading through day 7. Sloughing occurred in three abraded sites at the 6- and 7-day scorings. Edema was present at all intact and abraded sites throughout the study. The primary irritation index (PII) was 6.3 (Hill Top Research, Inc. 1980a). The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study. The NOEL for systemic effects was 25 mg/kg/day. The NOEL for skin effects was 1 mg/kg/day, whereas the LOEL for skin effects, based on acanthosis, hyper- keratosis, parakeratosis, dermatitis, and scabs, was 5 mg/kg/day. Dermal Sensitization Dichlorophene In a skin irritation and sensitization test reported by Haskell Laboratories(1950),Dichloropheneproducedminimalirritation when applied to the backs of 10 shaved guinea pigs. None of the guinea pigs had an allergic skin sensitization reaction. NIOSH (1980) performed a skin sensitization study using the samepatchmethodasfortheirdermalirritationstudiesdescribed earlier. The...","page":15,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_004"} |
| CIR Safety Assessment | NOAEL | =1 | mg/kg/day | rabbit | dermal | 7-day | NOAEL study | {"citation":"72; 7; 6","dose":"The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study.","effect":"were replaced. Coriaceousness occurred at all intact and abraded sites from the 72-h reading through day 7. Sloughing occurred in three abraded sites at the 6- and 7-day scorings. Edema was present at all intact and abraded sites throughout the study. The primary irritation index (PII) was 6.3 (Hill Top Research, Inc. 1980a). The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study. The NOEL for systemic effects was 25 mg/kg/day. The NOEL for skin effects was 1 mg/kg/day, whereas the LOEL for skin effects, based on acanthosis, hyper- keratosis, parakeratosis, dermatitis, and scabs, was 5 mg/kg/day. Dermal Sensitization Dichlorophene In a skin irritation and sensitization test reported by Haskell Laboratories(1950),Dichloropheneproducedminimalirritation when applied to the backs of 10 shaved guinea pigs. None of the guinea pigs had an allergic skin sensitization reaction. NIOSH (1980) performed a skin sensitization study using the samepatchmethodasfortheirdermalirritationstudiesdescribed earlier. The...","page":15,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_004"} |
| CIR Safety Assessment | NOAEL | =25 | mg/kg/day | rabbit | dermal | 7-day | NOAEL study | {"citation":"72; 7; 6","dose":"The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study.","effect":"and dark fluid in the intestines. These rabbits were replaced. Coriaceousness occurred at all intact and abraded sites from the 72-h reading through day 7. Sloughing occurred in three abraded sites at the 6- and 7-day scorings. Edema was present at all intact and abraded sites throughout the study. The primary irritation index (PII) was 6.3 (Hill Top Research, Inc. 1980a). The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study. The NOEL for systemic effects was 25 mg/kg/day. The NOEL for skin effects was 1 mg/kg/day, whereas the LOEL for skin effects, based on acanthosis, hyper- keratosis, parakeratosis, dermatitis, and scabs, was 5 mg/kg/day. Dermal Sensitization Dichlorophene In a skin irritation and sensitization test reported by Haskell Laboratories(1950),Dichloropheneproducedminimalirritation when applied to the backs of 10 shaved guinea pigs. None of the guinea pigs had an allergic skin sensitization reaction. NIOSH (1980) performed a skin sensitization study using the samepatchmethodasforthe...","page":15,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_003"} |
| CIR Safety Assessment | NOAEL | =25 | mg/kg/day | rabbit | dermal | 7-day | NOAEL study | {"citation":"72; 7; 6","dose":"The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study.","effect":"and dark fluid in the intestines. These rabbits were replaced. Coriaceousness occurred at all intact and abraded sites from the 72-h reading through day 7. Sloughing occurred in three abraded sites at the 6- and 7-day scorings. Edema was present at all intact and abraded sites throughout the study. The primary irritation index (PII) was 6.3 (Hill Top Research, Inc. 1980a). The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study. The NOEL for systemic effects was 25 mg/kg/day. The NOEL for skin effects was 1 mg/kg/day, whereas the LOEL for skin effects, based on acanthosis, hyper- keratosis, parakeratosis, dermatitis, and scabs, was 5 mg/kg/day. Dermal Sensitization Dichlorophene In a skin irritation and sensitization test reported by Haskell Laboratories(1950),Dichloropheneproducedminimalirritation when applied to the backs of 10 shaved guinea pigs. None of the guinea pigs had an allergic skin sensitization reaction. NIOSH (1980) performed a skin sensitization study using the samepatchmethodasforthe...","page":15,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_003"} |
| CIR Safety Assessment | NOAEL | =25 | mg/kg/day | rabbit | dermal | 7-day | NOAEL study | {"citation":"72; 7; 6","dose":"The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study.","effect":"and dark fluid in the intestines. These rabbits were replaced. Coriaceousness occurred at all intact and abraded sites from the 72-h reading through day 7. Sloughing occurred in three abraded sites at the 6- and 7-day scorings. Edema was present at all intact and abraded sites throughout the study. The primary irritation index (PII) was 6.3 (Hill Top Research, Inc. 1980a). The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study. The NOEL for systemic effects was 25 mg/kg/day. The NOEL for skin effects was 1 mg/kg/day, whereas the LOEL for skin effects, based on acanthosis, hyper- keratosis, parakeratosis, dermatitis, and scabs, was 5 mg/kg/day. Dermal Sensitization Dichlorophene In a skin irritation and sensitization test reported by Haskell Laboratories(1950),Dichloropheneproducedminimalirritation when applied to the backs of 10 shaved guinea pigs. None of the guinea pigs had an allergic skin sensitization reaction. NIOSH (1980) performed a skin sensitization study using the samepatchmethodasforthe...","page":15,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_003"} |
| CIR Safety Assessment | NOAEL | =25 | mg/kg/day | rabbit | dermal | 7-day | NOAEL study | {"citation":"72; 7; 6","dose":"The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study.","effect":"and dark fluid in the intestines. These rabbits were replaced. Coriaceousness occurred at all intact and abraded sites from the 72-h reading through day 7. Sloughing occurred in three abraded sites at the 6- and 7-day scorings. Edema was present at all intact and abraded sites throughout the study. The primary irritation index (PII) was 6.3 (Hill Top Research, Inc. 1980a). The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study. The NOEL for systemic effects was 25 mg/kg/day. The NOEL for skin effects was 1 mg/kg/day, whereas the LOEL for skin effects, based on acanthosis, hyper- keratosis, parakeratosis, dermatitis, and scabs, was 5 mg/kg/day. Dermal Sensitization Dichlorophene In a skin irritation and sensitization test reported by Haskell Laboratories(1950),Dichloropheneproducedminimalirritation when applied to the backs of 10 shaved guinea pigs. None of the guinea pigs had an allergic skin sensitization reaction. NIOSH (1980) performed a skin sensitization study using the samepatchmethodasforthe...","page":15,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_003"} |
| CIR Safety Assessment | NOAEL | =30 | mg/kg/day | rat | - | 2-year | developmental toxicity | {"citation":"30; 50; 150","dose":"n this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study.","effect":"n this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study. These doses were determined by a dose-finding study in which a 50% mortality rate occurred at 150 mg/kg/day and a 100% mortality rate occurred at 200 and 300 mg/kg/day. No maternal toxicity was observed at any dose, therefore the maternal NOEL was >100 mg/kg/day. Postimplantation loss was increased in the high-dose group compared to controls; however, litter sizes were comparable to controls. The NOEL and LOEL for developmental toxicity were 30 mg/kg/day and 100 mg/kg/day, respectively (EPA 1995). GENOTOXICITY Dichlorophene and Chlorophene genotoxicity studies are summarized in Table 3. Both positive and negative results were found. CARCINOGENICITY Marsman et al. (1995) conducted a 2-year study in which groups of 80 male rats/group received Chlorophene orally at doses of 30, 60, or 120 mg/kg body weight and groups of 80 fe- male rats/group received 60, 120, or 240 mg/kg Chlorophene orally. Groups of 70 mice/sex/group received 120, 240, or 480 mg/kg Chlorophene or...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_009"} |
| CIR Safety Assessment | NOAEL | =30 | mg/kg/day | rat | - | 2-year | developmental toxicity | {"citation":"30; 50; 150","dose":"n this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study.","effect":"n this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study. These doses were determined by a dose-finding study in which a 50% mortality rate occurred at 150 mg/kg/day and a 100% mortality rate occurred at 200 and 300 mg/kg/day. No maternal toxicity was observed at any dose, therefore the maternal NOEL was >100 mg/kg/day. Postimplantation loss was increased in the high-dose group compared to controls; however, litter sizes were comparable to controls. The NOEL and LOEL for developmental toxicity were 30 mg/kg/day and 100 mg/kg/day, respectively (EPA 1995). GENOTOXICITY Dichlorophene and Chlorophene genotoxicity studies are summarized in Table 3. Both positive and negative results were found. CARCINOGENICITY Marsman et al. (1995) conducted a 2-year study in which groups of 80 male rats/group received Chlorophene orally at doses of 30, 60, or 120 mg/kg body weight and groups of 80 fe- male rats/group received 60, 120, or 240 mg/kg Chlorophene orally. Groups of 70 mice/sex/group received 120, 240, or 480 mg/kg Chlorophene or...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_009"} |
| CIR Safety Assessment | NOAEL | =30 | mg/kg/day | rat | - | 2-year | developmental toxicity | {"citation":"30; 50; 150","dose":"n this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study.","effect":"n this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study. These doses were determined by a dose-finding study in which a 50% mortality rate occurred at 150 mg/kg/day and a 100% mortality rate occurred at 200 and 300 mg/kg/day. No maternal toxicity was observed at any dose, therefore the maternal NOEL was >100 mg/kg/day. Postimplantation loss was increased in the high-dose group compared to controls; however, litter sizes were comparable to controls. The NOEL and LOEL for developmental toxicity were 30 mg/kg/day and 100 mg/kg/day, respectively (EPA 1995). GENOTOXICITY Dichlorophene and Chlorophene genotoxicity studies are summarized in Table 3. Both positive and negative results were found. CARCINOGENICITY Marsman et al. (1995) conducted a 2-year study in which groups of 80 male rats/group received Chlorophene orally at doses of 30, 60, or 120 mg/kg body weight and groups of 80 fe- male rats/group received 60, 120, or 240 mg/kg Chlorophene orally. Groups of 70 mice/sex/group received 120, 240, or 480 mg/kg Chlorophene or...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_009"} |
| CIR Safety Assessment | NOAEL | =30 | mg/kg/day | rat | - | 2-year | developmental toxicity | {"citation":"30; 50; 150","dose":"n this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study.","effect":"n this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study. These doses were determined by a dose-finding study in which a 50% mortality rate occurred at 150 mg/kg/day and a 100% mortality rate occurred at 200 and 300 mg/kg/day. No maternal toxicity was observed at any dose, therefore the maternal NOEL was >100 mg/kg/day. Postimplantation loss was increased in the high-dose group compared to controls; however, litter sizes were comparable to controls. The NOEL and LOEL for developmental toxicity were 30 mg/kg/day and 100 mg/kg/day, respectively (EPA 1995). GENOTOXICITY Dichlorophene and Chlorophene genotoxicity studies are summarized in Table 3. Both positive and negative results were found. CARCINOGENICITY Marsman et al. (1995) conducted a 2-year study in which groups of 80 male rats/group received Chlorophene orally at doses of 30, 60, or 120 mg/kg body weight and groups of 80 fe- male rats/group received 60, 120, or 240 mg/kg Chlorophene orally. Groups of 70 mice/sex/group received 120, 240, or 480 mg/kg Chlorophene or...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_009"} |
| CIR Safety Assessment | NOAEL | =75 | mg/kg/day | rat | - | - | developmental toxicity | {"citation":"100; 900; 15, 75","dose":"intake by the high-dose group was increased.","effect":"intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, mortality, and increased mucoid feces. The NOEL for developmental toxicity was 75 mg/kg/day. The developmental LOEL was 375 mg/kg/day based on a de- crease in mean fetal weight. Also in this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study. These doses were determined by a dose-finding study in which a 50% mortality rate occurred at 150 mg/kg/day and a 100% mortality rate occurred at 200 and 300 mg/kg...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_007"} |
| CIR Safety Assessment | NOAEL | =75 | mg/kg/day | rat | - | - | developmental toxicity | {"citation":"100; 900; 15, 75","dose":"intake by the high-dose group was increased.","effect":"intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, mortality, and increased mucoid feces. The NOEL for developmental toxicity was 75 mg/kg/day. The developmental LOEL was 375 mg/kg/day based on a de- crease in mean fetal weight. Also in this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study. These doses were determined by a dose-finding study in which a 50% mortality rate occurred at 150 mg/kg/day and a 100% mortality rate occurred at 200 and 300 mg/kg...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_007"} |
| CIR Safety Assessment | NOAEL | =75 | mg/kg/day | rat | - | - | developmental toxicity | {"citation":"100; 900; 15, 75","dose":"intake by the high-dose group was increased.","effect":"intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, mortality, and increased mucoid feces. The NOEL for developmental toxicity was 75 mg/kg/day. The developmental LOEL was 375 mg/kg/day based on a de- crease in mean fetal weight. Also in this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study. These doses were determined by a dose-finding study in which a 50% mortality rate occurred at 150 mg/kg/day and a 100% mortality rate occurred at 200 and 300 mg/kg...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_007"} |
| CIR Safety Assessment | NOAEL | =75 | mg/kg/day | rat | - | - | developmental toxicity | {"citation":"100; 900; 15, 75","dose":"intake by the high-dose group was increased.","effect":"intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, mortality, and increased mucoid feces. The NOEL for developmental toxicity was 75 mg/kg/day. The developmental LOEL was 375 mg/kg/day based on a de- crease in mean fetal weight. Also in this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study. These doses were determined by a dose-finding study in which a 50% mortality rate occurred at 150 mg/kg/day and a 100% mortality rate occurred at 200 and 300 mg/kg...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_007"} |
| CIR Safety Assessment | NOAEL | <100 | mg/kg/day | rat | oral | - | developmental toxicity | {"citation":"100, 300; 900; 6","dose":"igh-dose groups, but was significantly greater in the mid-dose group than in con- trols.","effect":"igh-dose groups, but was significantly greater in the mid-dose group than in con- trols. (Bio/Dynamics, Inc. 1979). In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation. A control group was also included in the study. Rats had statistically significantly decreased body weight at all doses. Animals of the mid- and high-dose groups had de- creased mean feed consumption. Water intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, morta...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_005"} |
| CIR Safety Assessment | NOAEL | <100 | mg/kg/day | rat | oral | - | developmental toxicity | {"citation":"100, 300; 900; 6","dose":"igh-dose groups, but was significantly greater in the mid-dose group than in con- trols.","effect":"igh-dose groups, but was significantly greater in the mid-dose group than in con- trols. (Bio/Dynamics, Inc. 1979). In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation. A control group was also included in the study. Rats had statistically significantly decreased body weight at all doses. Animals of the mid- and high-dose groups had de- creased mean feed consumption. Water intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, morta...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_005"} |
| CIR Safety Assessment | NOAEL | <100 | mg/kg/day | rat | oral | - | developmental toxicity | {"citation":"100, 300; 900; 6","dose":"igh-dose groups, but was significantly greater in the mid-dose group than in con- trols.","effect":"igh-dose groups, but was significantly greater in the mid-dose group than in con- trols. (Bio/Dynamics, Inc. 1979). In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation. A control group was also included in the study. Rats had statistically significantly decreased body weight at all doses. Animals of the mid- and high-dose groups had de- creased mean feed consumption. Water intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, morta...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_005"} |
| CIR Safety Assessment | NOAEL | <100 | mg/kg/day | rat | oral | - | developmental toxicity | {"citation":"100, 300; 900; 6","dose":"igh-dose groups, but was significantly greater in the mid-dose group than in con- trols.","effect":"igh-dose groups, but was significantly greater in the mid-dose group than in con- trols. (Bio/Dynamics, Inc. 1979). In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation. A control group was also included in the study. Rats had statistically significantly decreased body weight at all doses. Animals of the mid- and high-dose groups had de- creased mean feed consumption. Water intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, morta...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_005"} |
| CIR Safety Assessment | NOAEL | =120 | mg/kg/day | rat | oral | 5 days | oral toxicity | {"citation":"11; 5; 13","dose":"Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively.","effect":"DICHLOROPHENE AND CHLOROPHENE 11 suppurative inflammation of the olfactory epithelium and were probably caused by the caustic nature of the compound and the gavage route of administration (NTP 1994). This study was also published by Marsman et al. (1995). Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively. A control group was also in- cluded in the study. In rats, the reported no-observable-effect level (NOEL) was 120 mg/kg/day and the lowest-observable ef- fect level (LOEL) was 240 mg/kg/day. A NOEL was not deter- mined for mice because renal lesions were present at the lowest dose tested (EPA 1995). Chronic Oral Toxicity Chlorophene In an NTP (1994) study, male and female rats (80/sex/group) were given Chlorophene in corn oil orally at doses of 30, 60, or 120 mg/kg and 60, 120, or 240 mg/kg, respectively, for 2 years. Male and female mice (70/sex/group) received Chlorophene orally at doses of 120, 240, or 480 mg/kg for 2 years. A con- trol group was included with each study. Rats were housed...","page":11,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_001"} |
| CIR Safety Assessment | NOAEL | =120 | mg/kg/day | rat | oral | 5 days | oral toxicity | {"citation":"11; 5; 13","dose":"Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively.","effect":"DICHLOROPHENE AND CHLOROPHENE 11 suppurative inflammation of the olfactory epithelium and were probably caused by the caustic nature of the compound and the gavage route of administration (NTP 1994). This study was also published by Marsman et al. (1995). Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively. A control group was also in- cluded in the study. In rats, the reported no-observable-effect level (NOEL) was 120 mg/kg/day and the lowest-observable ef- fect level (LOEL) was 240 mg/kg/day. A NOEL was not deter- mined for mice because renal lesions were present at the lowest dose tested (EPA 1995). Chronic Oral Toxicity Chlorophene In an NTP (1994) study, male and female rats (80/sex/group) were given Chlorophene in corn oil orally at doses of 30, 60, or 120 mg/kg and 60, 120, or 240 mg/kg, respectively, for 2 years. Male and female mice (70/sex/group) received Chlorophene orally at doses of 120, 240, or 480 mg/kg for 2 years. A con- trol group was included with each study. Rats were housed...","page":11,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_001"} |
| CIR Safety Assessment | NOAEL | =120 | mg/kg/day | rat | oral | 5 days | oral toxicity | {"citation":"11; 5; 13","dose":"Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively.","effect":"DICHLOROPHENE AND CHLOROPHENE 11 suppurative inflammation of the olfactory epithelium and were probably caused by the caustic nature of the compound and the gavage route of administration (NTP 1994). This study was also published by Marsman et al. (1995). Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively. A control group was also in- cluded in the study. In rats, the reported no-observable-effect level (NOEL) was 120 mg/kg/day and the lowest-observable ef- fect level (LOEL) was 240 mg/kg/day. A NOEL was not deter- mined for mice because renal lesions were present at the lowest dose tested (EPA 1995). Chronic Oral Toxicity Chlorophene In an NTP (1994) study, male and female rats (80/sex/group) were given Chlorophene in corn oil orally at doses of 30, 60, or 120 mg/kg and 60, 120, or 240 mg/kg, respectively, for 2 years. Male and female mice (70/sex/group) received Chlorophene orally at doses of 120, 240, or 480 mg/kg for 2 years. A con- trol group was included with each study. Rats were housed...","page":11,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_001"} |
| CIR Safety Assessment | NOAEL | =120 | mg/kg/day | rat | oral | 5 days | oral toxicity | {"citation":"11; 5; 13","dose":"Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively.","effect":"DICHLOROPHENE AND CHLOROPHENE 11 suppurative inflammation of the olfactory epithelium and were probably caused by the caustic nature of the compound and the gavage route of administration (NTP 1994). This study was also published by Marsman et al. (1995). Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively. A control group was also in- cluded in the study. In rats, the reported no-observable-effect level (NOEL) was 120 mg/kg/day and the lowest-observable ef- fect level (LOEL) was 240 mg/kg/day. A NOEL was not deter- mined for mice because renal lesions were present at the lowest dose tested (EPA 1995). Chronic Oral Toxicity Chlorophene In an NTP (1994) study, male and female rats (80/sex/group) were given Chlorophene in corn oil orally at doses of 30, 60, or 120 mg/kg and 60, 120, or 240 mg/kg, respectively, for 2 years. Male and female mice (70/sex/group) received Chlorophene orally at doses of 120, 240, or 480 mg/kg for 2 years. A con- trol group was included with each study. Rats were housed...","page":11,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_001"} |
| CIR Safety Assessment | NOAEL | =240 | mg/kg/day | rat | oral | 5 days | oral toxicity | {"citation":"5; 13; 30, 60, 120, 240","dose":"Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively.","effect":"ctory epithelium and were probably caused by the caustic nature of the compound and the gavage route of administration (NTP 1994). This study was also published by Marsman et al. (1995). Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively. A control group was also in- cluded in the study. In rats, the reported no-observable-effect level (NOEL) was 120 mg/kg/day and the lowest-observable ef- fect level (LOEL) was 240 mg/kg/day. A NOEL was not deter- mined for mice because renal lesions were present at the lowest dose tested (EPA 1995). Chronic Oral Toxicity Chlorophene In an NTP (1994) study, male and female rats (80/sex/group) were given Chlorophene in corn oil orally at doses of 30, 60, or 120 mg/kg and 60, 120, or 240 mg/kg, respectively, for 2 years. Male and female mice (70/sex/group) received Chlorophene orally at doses of 120, 240, or 480 mg/kg for 2 years. A con- trol group was included with each study. Rats were housed five per cage and mice were housed individually. Survival of rats was...","page":11,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_002"} |
| CIR Safety Assessment | NOAEL | =240 | mg/kg/day | rat | oral | 5 days | oral toxicity | {"citation":"5; 13; 30, 60, 120, 240","dose":"Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively.","effect":"ctory epithelium and were probably caused by the caustic nature of the compound and the gavage route of administration (NTP 1994). This study was also published by Marsman et al. (1995). Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively. A control group was also in- cluded in the study. In rats, the reported no-observable-effect level (NOEL) was 120 mg/kg/day and the lowest-observable ef- fect level (LOEL) was 240 mg/kg/day. A NOEL was not deter- mined for mice because renal lesions were present at the lowest dose tested (EPA 1995). Chronic Oral Toxicity Chlorophene In an NTP (1994) study, male and female rats (80/sex/group) were given Chlorophene in corn oil orally at doses of 30, 60, or 120 mg/kg and 60, 120, or 240 mg/kg, respectively, for 2 years. Male and female mice (70/sex/group) received Chlorophene orally at doses of 120, 240, or 480 mg/kg for 2 years. A con- trol group was included with each study. Rats were housed five per cage and mice were housed individually. Survival of rats was...","page":11,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_002"} |
| CIR Safety Assessment | NOAEL | =240 | mg/kg/day | rat | oral | 5 days | oral toxicity | {"citation":"5; 13; 30, 60, 120, 240","dose":"Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively.","effect":"ctory epithelium and were probably caused by the caustic nature of the compound and the gavage route of administration (NTP 1994). This study was also published by Marsman et al. (1995). Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively. A control group was also in- cluded in the study. In rats, the reported no-observable-effect level (NOEL) was 120 mg/kg/day and the lowest-observable ef- fect level (LOEL) was 240 mg/kg/day. A NOEL was not deter- mined for mice because renal lesions were present at the lowest dose tested (EPA 1995). Chronic Oral Toxicity Chlorophene In an NTP (1994) study, male and female rats (80/sex/group) were given Chlorophene in corn oil orally at doses of 30, 60, or 120 mg/kg and 60, 120, or 240 mg/kg, respectively, for 2 years. Male and female mice (70/sex/group) received Chlorophene orally at doses of 120, 240, or 480 mg/kg for 2 years. A con- trol group was included with each study. Rats were housed five per cage and mice were housed individually. Survival of rats was...","page":11,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_002"} |
| CIR Safety Assessment | NOAEL | =240 | mg/kg/day | rat | oral | 5 days | oral toxicity | {"citation":"5; 13; 30, 60, 120, 240","dose":"Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively.","effect":"ctory epithelium and were probably caused by the caustic nature of the compound and the gavage route of administration (NTP 1994). This study was also published by Marsman et al. (1995). Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively. A control group was also in- cluded in the study. In rats, the reported no-observable-effect level (NOEL) was 120 mg/kg/day and the lowest-observable ef- fect level (LOEL) was 240 mg/kg/day. A NOEL was not deter- mined for mice because renal lesions were present at the lowest dose tested (EPA 1995). Chronic Oral Toxicity Chlorophene In an NTP (1994) study, male and female rats (80/sex/group) were given Chlorophene in corn oil orally at doses of 30, 60, or 120 mg/kg and 60, 120, or 240 mg/kg, respectively, for 2 years. Male and female mice (70/sex/group) received Chlorophene orally at doses of 120, 240, or 480 mg/kg for 2 years. A con- trol group was included with each study. Rats were housed five per cage and mice were housed individually. Survival of rats was...","page":11,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_002"} |
| CIR Safety Assessment | NOAEL | >900 | mg/kg/day | rat | oral | - | developmental toxicity | {"citation":"100, 300; 900; 6","dose":"In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation.","effect":"namics, Inc. 1979). In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation. A control group was also included in the study. Rats had statistically significantly decreased body weight at all doses. Animals of the mid- and high-dose groups had de- creased mean feed consumption. Water intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, mortality, and increased mucoid feces. The NOEL for developmental toxicity was 75 mg/kg/day. The deve...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_006"} |
| CIR Safety Assessment | NOAEL | >900 | mg/kg/day | rat | oral | - | developmental toxicity | {"citation":"100, 300; 900; 6","dose":"In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation.","effect":"namics, Inc. 1979). In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation. A control group was also included in the study. Rats had statistically significantly decreased body weight at all doses. Animals of the mid- and high-dose groups had de- creased mean feed consumption. Water intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, mortality, and increased mucoid feces. The NOEL for developmental toxicity was 75 mg/kg/day. The deve...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_006"} |
| CIR Safety Assessment | NOAEL | >900 | mg/kg/day | rat | oral | - | developmental toxicity | {"citation":"100, 300; 900; 6","dose":"In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation.","effect":"namics, Inc. 1979). In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation. A control group was also included in the study. Rats had statistically significantly decreased body weight at all doses. Animals of the mid- and high-dose groups had de- creased mean feed consumption. Water intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, mortality, and increased mucoid feces. The NOEL for developmental toxicity was 75 mg/kg/day. The deve...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_006"} |
| CIR Safety Assessment | NOAEL | >900 | mg/kg/day | rat | oral | - | developmental toxicity | {"citation":"100, 300; 900; 6","dose":"In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation.","effect":"namics, Inc. 1979). In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation. A control group was also included in the study. Rats had statistically significantly decreased body weight at all doses. Animals of the mid- and high-dose groups had de- creased mean feed consumption. Water intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, mortality, and increased mucoid feces. The NOEL for developmental toxicity was 75 mg/kg/day. The deve...","page":17,"pdf":"PRS284.pdf","row_type":"noael_study","study_id":"PRS284_noael_006"} |
California Proposition 65 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 listing | ABdevelopmental | listing type | - | - | 1999-04-27 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"1999-04-27","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABdevelopmental | listing type | - | - | 1999-04-27 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"1999-04-27","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABdevelopmental | listing type | - | - | 1999-04-27 | California Proposition 65 listing | {"cancer_reproductive":"developmental","listed_date":"1999-04-27","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =1506 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11841; row=10074; data_type=In Vivo; mixture=Chemical; chemical_name=Dichlorophen; preferred_name=Dichlorophen; dtxsid=DTXSID6021824; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6021824; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1683 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11842; row=10075; data_type=In Vivo; mixture=Chemical; chemical_name=Dichlorophen; preferred_name=Dichlorophen; dtxsid=DTXSID6021824; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6021824; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 13.2 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=2379; Record_ID=adme_parameters_969; Data_Type=Measured; DTXSID=DTXSID6021824; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=13.2; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE adme parameters | Fu | 0.0045 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=2378; Record_ID=adme_parameters_969; Data_Type=Measured; DTXSID=DTXSID6021824; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0045; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
NTP ICE endocrine 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 15.48201604 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=7746; RecordID=ARPathway2016_321; DatasetName=ARPathway2016; DTXSID=DTXSID6021824; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=15.48201604; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE endocrine | AC50 | 17.199492691799 | uM | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=7752; RecordID=ERPathway2016_32; DatasetName=ERPathway2016; DTXSID=DTXSID6021824; Assay=ER Pathway Model, Agonist; Endpoint=AC50; Response=17.199492691799; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE endocrine | ACC | 14.8521862953658 | uM | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=7753; RecordID=ERPathway2016_32; DatasetName=ERPathway2016; DTXSID=DTXSID6021824; Assay=ER Pathway Model, Agonist; Endpoint=ACC; Response=14.8521862953658; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE endocrine | ACC | 16.0241547366554 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=7747; RecordID=ARPathway2016_321; DatasetName=ARPathway2016; DTXSID=DTXSID6021824; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=16.0241547366554; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=7749; RecordID=ARPathway2016_321; DatasetName=ARPathway2016; DTXSID=DTXSID6021824; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE endocrine | Model Score | 0.0058 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=7754; RecordID=ERPathway2016_32; DatasetName=ERPathway2016; DTXSID=DTXSID6021824; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0058; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE endocrine | Model Score | 0.0643 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=7755; RecordID=ERPathway2016_32; DatasetName=ERPathway2016; DTXSID=DTXSID6021824; Assay=ER Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0643; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE endocrine | Model Score | 0.337 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=7748; RecordID=ARPathway2016_321; DatasetName=ARPathway2016; DTXSID=DTXSID6021824; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.337; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
NTP ICE skin sensitization 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 37.5 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11440; Record_ID=skin_sensitization_invivo_2485; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=37.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 110 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11463; Record_ID=skin_sensitization_invivo_2489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=110; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE skin sensitization | Concentration, one positive response | 5 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11436; Record_ID=skin_sensitization_invivo_2485; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE skin sensitization | Concentration, one positive response | 20 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11459; Record_ID=skin_sensitization_invivo_2489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=20; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11448; Record_ID=skin_sensitization_invivo_2487; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE skin sensitization | Incidence of positive responses | 0.6667 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11433; Record_ID=skin_sensitization_invivo_2485; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0.6667; Response_Unit=%; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE skin sensitization | Incidence of positive responses | 0.9091 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11456; Record_ID=skin_sensitization_invivo_2489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0.9091; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE skin sensitization | Induction dose per skin area | 3488 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11446; Record_ID=skin_sensitization_invivo_2487; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=3488; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE skin sensitization | Induction dose per skin area | 5625 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11431; Record_ID=skin_sensitization_invivo_2485; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=5625; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE skin sensitization | Induction dose per skin area | 13950 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11454; Record_ID=skin_sensitization_invivo_2489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=13950; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 42187.5 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11442; Record_ID=skin_sensitization_invivo_2485; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=42187.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 76730 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11465; Record_ID=skin_sensitization_invivo_2489; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=76730; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11444; Record_ID=skin_sensitization_invivo_2485; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6021824; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Jordan Jr and King 1977; 844299; 10.1111/j.1600-0536.1977.tb03582.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021824; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6021824 |
Regulatory source 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 1 | mg/kg/day | rabbit | dermal | 7-day | - | SOURCE_SUBDIR=PRS284; REPORT_TITLE=Safety Assessment of Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a; OPINION_NUMBER=PRS284; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=18 July 2003; VALUE_TEXT=1; DOSE=The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study.; EFFECT=were replaced. Coriaceousness occurred at all intact and abraded sites from the 72-h reading through day 7. Sloughing occurred in three abraded sites at the 6- and 7-day scorings. Edema was present at all intact and abraded sites throughout the study. The primary irritation index (PII) was 6.3 (Hill Top Research, Inc. 1980a). The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study. The NOEL for systemic effects was 25 mg/kg/day. The NOEL for skin effects was 1 mg/kg/day, whereas the LOEL for skin effects, based on acanthosis, hyper- keratosis, parakeratosis, dermatitis, and scabs, was 5 mg/kg/day. Dermal Sensitization Dichlorophene In a skin irritation and sensitization test reported by Haskell Laboratories(1950),Dichloropheneproducedminimalirritation when applied to the backs of 10 shaved guinea pigs. None of the guinea pigs had an allergic skin sensitization reaction. NIOSH (1980) performed a skin sensitization study using the samepatchmethodasfortheirdermalirritationstudiesdescribed earlier. The...; CITATION=72; 7; 6; CITATION_NUMBERS=[72,7,6]; REFERENCE=72; 7; 6; DETAILS_JSON={"cas_number":"97-23-4","citation":"72; 7; 6","dose":"The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study.","duration":"7-day","effect":"were replaced. Coriaceousness occurred at all intact and abraded sites from the 72-h reading through day 7. Sloughing occurred in three abraded sites at the 6- and 7-day scorings. Edema was present at all intact and abraded sites throughout the study. The primary irritation index (PII) was 6.3 (Hill Top Research, Inc. 1980a). The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study. The NOEL for systemic effects was 25 mg/kg/day. The NOEL for skin effects was 1 mg/kg/day, whereas the LOEL for skin effects, based on acanthosis, hyper- keratosis, parakeratosis, dermatitis, and scabs, was 5 mg/kg/day. Dermal Sensitization Dichlorophene In a skin irritation and sensitization test reported by Haskell Laboratories(1950),Dichloropheneproducedminimalirritation when applied to the backs of 10 shaved guinea pigs. None of the guinea pigs had an allergic skin sensitization reaction. NIOSH (1980) performed a skin sensitization study using the samepatchmethodasfortheirdermalirritationstudiesdescribed earlier. The...","endpoint":"","ingredient":"Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a","loael_value":"","noael_unit":"mg/kg/day","noael_value":"1","page":15,"route":"dermal","species":"rabbit","study_id":"PRS284_noael_004"} |
| Regulatory source | - | 25 | mg/kg/day | rabbit | dermal | 7-day | - | SOURCE_SUBDIR=PRS284; REPORT_TITLE=Safety Assessment of Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a; OPINION_NUMBER=PRS284; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=18 July 2003; VALUE_TEXT=25; DOSE=The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study.; EFFECT=and dark fluid in the intestines. These rabbits were replaced. Coriaceousness occurred at all intact and abraded sites from the 72-h reading through day 7. Sloughing occurred in three abraded sites at the 6- and 7-day scorings. Edema was present at all intact and abraded sites throughout the study. The primary irritation index (PII) was 6.3 (Hill Top Research, Inc. 1980a). The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study. The NOEL for systemic effects was 25 mg/kg/day. The NOEL for skin effects was 1 mg/kg/day, whereas the LOEL for skin effects, based on acanthosis, hyper- keratosis, parakeratosis, dermatitis, and scabs, was 5 mg/kg/day. Dermal Sensitization Dichlorophene In a skin irritation and sensitization test reported by Haskell Laboratories(1950),Dichloropheneproducedminimalirritation when applied to the backs of 10 shaved guinea pigs. None of the guinea pigs had an allergic skin sensitization reaction. NIOSH (1980) performed a skin sensitization study using the samepatchmethodasforthe...; CITATION=72; 7; 6; CITATION_NUMBERS=[72,7,6]; REFERENCE=72; 7; 6; DETAILS_JSON={"cas_number":"97-23-4","citation":"72; 7; 6","dose":"The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study.","duration":"7-day","effect":"and dark fluid in the intestines. These rabbits were replaced. Coriaceousness occurred at all intact and abraded sites from the 72-h reading through day 7. Sloughing occurred in three abraded sites at the 6- and 7-day scorings. Edema was present at all intact and abraded sites throughout the study. The primary irritation index (PII) was 6.3 (Hill Top Research, Inc. 1980a). The EPA (1995) reported a study in which New Zealand rabbits were dosed with 0, 1, 5, or 25 mg/kg/day Chlorophene in a 21-day dermal study. The NOEL for systemic effects was 25 mg/kg/day. The NOEL for skin effects was 1 mg/kg/day, whereas the LOEL for skin effects, based on acanthosis, hyper- keratosis, parakeratosis, dermatitis, and scabs, was 5 mg/kg/day. Dermal Sensitization Dichlorophene In a skin irritation and sensitization test reported by Haskell Laboratories(1950),Dichloropheneproducedminimalirritation when applied to the backs of 10 shaved guinea pigs. None of the guinea pigs had an allergic skin sensitization reaction. NIOSH (1980) performed a skin sensitization study using the samepatchmethodasforthe...","endpoint":"","ingredient":"Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a","loael_value":"","noael_unit":"mg/kg/day","noael_value":"25","page":15,"route":"dermal","species":"rabbit","study_id":"PRS284_noael_003"} |
| Regulatory source | developmental toxicity | 30 | mg/kg/day | rat | - | 2-year | developmental toxicity | SOURCE_SUBDIR=PRS284; REPORT_TITLE=Safety Assessment of Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a; OPINION_NUMBER=PRS284; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=18 July 2003; VALUE_TEXT=30; DOSE=n this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study.; EFFECT=n this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study. These doses were determined by a dose-finding study in which a 50% mortality rate occurred at 150 mg/kg/day and a 100% mortality rate occurred at 200 and 300 mg/kg/day. No maternal toxicity was observed at any dose, therefore the maternal NOEL was >100 mg/kg/day. Postimplantation loss was increased in the high-dose group compared to controls; however, litter sizes were comparable to controls. The NOEL and LOEL for developmental toxicity were 30 mg/kg/day and 100 mg/kg/day, respectively (EPA 1995). GENOTOXICITY Dichlorophene and Chlorophene genotoxicity studies are summarized in Table 3. Both positive and negative results were found. CARCINOGENICITY Marsman et al. (1995) conducted a 2-year study in which groups of 80 male rats/group received Chlorophene orally at doses of 30, 60, or 120 mg/kg body weight and groups of 80 fe- male rats/group received 60, 120, or 240 mg/kg Chlorophene orally. Groups of 70 mice/sex/group received 120, 240, or 480 mg/kg Chlorophene or...; CITATION=30; 50; 150; CITATION_NUMBERS=[30,50,150]; REFERENCE=30; 50; 150; DETAILS_JSON={"cas_number":"97-23-4","citation":"30; 50; 150","dose":"n this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study.","duration":"2-year","effect":"n this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study. These doses were determined by a dose-finding study in which a 50% mortality rate occurred at 150 mg/kg/day and a 100% mortality rate occurred at 200 and 300 mg/kg/day. No maternal toxicity was observed at any dose, therefore the maternal NOEL was >100 mg/kg/day. Postimplantation loss was increased in the high-dose group compared to controls; however, litter sizes were comparable to controls. The NOEL and LOEL for developmental toxicity were 30 mg/kg/day and 100 mg/kg/day, respectively (EPA 1995). GENOTOXICITY Dichlorophene and Chlorophene genotoxicity studies are summarized in Table 3. Both positive and negative results were found. CARCINOGENICITY Marsman et al. (1995) conducted a 2-year study in which groups of 80 male rats/group received Chlorophene orally at doses of 30, 60, or 120 mg/kg body weight and groups of 80 fe- male rats/group received 60, 120, or 240 mg/kg Chlorophene orally. Groups of 70 mice/sex/group received 120, 240, or 480 mg/kg Chlorophene or...","endpoint":"developmental toxicity","ingredient":"Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a","loael_value":"","noael_unit":"mg/kg/day","noael_value":"30","page":17,"route":"","species":"rat","study_id":"PRS284_noael_009"} |
| Regulatory source | developmental toxicity | 75 | mg/kg/day | rat | - | - | developmental toxicity | SOURCE_SUBDIR=PRS284; REPORT_TITLE=Safety Assessment of Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a; OPINION_NUMBER=PRS284; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=18 July 2003; VALUE_TEXT=75; DOSE=intake by the high-dose group was increased.; EFFECT=intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, mortality, and increased mucoid feces. The NOEL for developmental toxicity was 75 mg/kg/day. The developmental LOEL was 375 mg/kg/day based on a de- crease in mean fetal weight. Also in this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study. These doses were determined by a dose-finding study in which a 50% mortality rate occurred at 150 mg/kg/day and a 100% mortality rate occurred at 200 and 300 mg/kg...; CITATION=100; 900; 15, 75; CITATION_NUMBERS=[100,900,15,75]; REFERENCE=100; 900; 15, 75; DETAILS_JSON={"cas_number":"97-23-4","citation":"100; 900; 15, 75","dose":"intake by the high-dose group was increased.","duration":"","effect":"intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, mortality, and increased mucoid feces. The NOEL for developmental toxicity was 75 mg/kg/day. The developmental LOEL was 375 mg/kg/day based on a de- crease in mean fetal weight. Also in this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study. These doses were determined by a dose-finding study in which a 50% mortality rate occurred at 150 mg/kg/day and a 100% mortality rate occurred at 200 and 300 mg/kg...","endpoint":"developmental toxicity","ingredient":"Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a","loael_value":"","noael_unit":"mg/kg/day","noael_value":"75","page":17,"route":"","species":"rat","study_id":"PRS284_noael_007"} |
| Regulatory source | developmental toxicity | 75 | mg/kg/day | rat | dermal | - | developmental toxicity | SOURCE_SUBDIR=PRS284; REPORT_TITLE=Safety Assessment of Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a; OPINION_NUMBER=PRS284; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=18 July 2003; VALUE_TEXT=75; 375; DOSE=Dichlorophene up to 10% concentration resulted in no to minimal irritation when applied to the intact and abraded skin of rabbits.; EFFECT=e. Dichlorophene up to 10% concentration resulted in no to minimal irritation when applied to the intact and abraded skin of rabbits. Chlorophene was severely irritating to rabbits in most dermal irritation stud- ies. Studies on guinea pigs gave positive and negative results in sensitization tests of Dichlorophene. A dose-related contact hy- persensitivity response to Chlorophene was reported in contact hypersensitization tests in mice and Chlorophene was classified as a weak sensitizer. The developmental LOEL and NOEL for rats was 75 and 375 mg/kg/day, respectively; however another study reported the developmental NOEL for rats as >900 mg/kg/day. All five rabbits dosed with 300 mg/kg/day on days 7 to 19 of gesta- tion died and no developmental abnormalities were observed in the fetuses of the 30- and 100-mg/kg/day groups. In another study with rabbits dosed during the same gestation period, those animals dosed with 80 mg/kg/day had significantly greater in- cidences of developmental malformations than controls. Dichlorophene was positive in the Ames mutagenicity as- say, but not...; CITATION=10; 75; 375; CITATION_NUMBERS=[10,75,375]; REFERENCE=10; 75; 375; DETAILS_JSON={"cas_number":"97-23-4","citation":"10; 75; 375","dose":"Dichlorophene up to 10% concentration resulted in no to minimal irritation when applied to the intact and abraded skin of rabbits.","duration":"","effect":"e. Dichlorophene up to 10% concentration resulted in no to minimal irritation when applied to the intact and abraded skin of rabbits. Chlorophene was severely irritating to rabbits in most dermal irritation stud- ies. Studies on guinea pigs gave positive and negative results in sensitization tests of Dichlorophene. A dose-related contact hy- persensitivity response to Chlorophene was reported in contact hypersensitization tests in mice and Chlorophene was classified as a weak sensitizer. The developmental LOEL and NOEL for rats was 75 and 375 mg/kg/day, respectively; however another study reported the developmental NOEL for rats as >900 mg/kg/day. All five rabbits dosed with 300 mg/kg/day on days 7 to 19 of gesta- tion died and no developmental abnormalities were observed in the fetuses of the 30- and 100-mg/kg/day groups. In another study with rabbits dosed during the same gestation period, those animals dosed with 80 mg/kg/day had significantly greater in- cidences of developmental malformations than controls. Dichlorophene was positive in the Ames mutagenicity as- say, but not...","endpoint":"developmental toxicity","ingredient":"Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a","loael_value":"","noael_unit":"mg/kg/day","noael_value":"75; 375","page":24,"route":"dermal","species":"rat","study_id":"PRS284_noael_011"} |
| Regulatory source | developmental toxicity | <100 | mg/kg/day | rat | oral | - | developmental toxicity | SOURCE_SUBDIR=PRS284; REPORT_TITLE=Safety Assessment of Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a; OPINION_NUMBER=PRS284; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=18 July 2003; VALUE_TEXT=< 100; DOSE=igh-dose groups, but was significantly greater in the mid-dose group than in con- trols.; EFFECT=igh-dose groups, but was significantly greater in the mid-dose group than in con- trols. (Bio/Dynamics, Inc. 1979). In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation. A control group was also included in the study. Rats had statistically significantly decreased body weight at all doses. Animals of the mid- and high-dose groups had de- creased mean feed consumption. Water intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, morta...; CITATION=100, 300; 900; 6; CITATION_NUMBERS=[100,300,900,6]; REFERENCE=100, 300; 900; 6; DETAILS_JSON={"cas_number":"97-23-4","citation":"100, 300; 900; 6","dose":"igh-dose groups, but was significantly greater in the mid-dose group than in con- trols.","duration":"","effect":"igh-dose groups, but was significantly greater in the mid-dose group than in con- trols. (Bio/Dynamics, Inc. 1979). In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation. A control group was also included in the study. Rats had statistically significantly decreased body weight at all doses. Animals of the mid- and high-dose groups had de- creased mean feed consumption. Water intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, morta...","endpoint":"developmental toxicity","ingredient":"Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a","loael_value":"","noael_unit":"mg/kg/day","noael_value":"< 100","page":17,"route":"oral","species":"rat","study_id":"PRS284_noael_005"} |
| Regulatory source | developmental toxicity | >100 | mg/kg/day | rat | - | 2-year | developmental toxicity | SOURCE_SUBDIR=PRS284; REPORT_TITLE=Safety Assessment of Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a; OPINION_NUMBER=PRS284; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=18 July 2003; VALUE_TEXT=> 100; DOSE=The NOEL for developmental toxicity was 75 mg/kg/day.; EFFECT=d mucoid feces. The NOEL for developmental toxicity was 75 mg/kg/day. The developmental LOEL was 375 mg/kg/day based on a de- crease in mean fetal weight. Also in this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study. These doses were determined by a dose-finding study in which a 50% mortality rate occurred at 150 mg/kg/day and a 100% mortality rate occurred at 200 and 300 mg/kg/day. No maternal toxicity was observed at any dose, therefore the maternal NOEL was >100 mg/kg/day. Postimplantation loss was increased in the high-dose group compared to controls; however, litter sizes were comparable to controls. The NOEL and LOEL for developmental toxicity were 30 mg/kg/day and 100 mg/kg/day, respectively (EPA 1995). GENOTOXICITY Dichlorophene and Chlorophene genotoxicity studies are summarized in Table 3. Both positive and negative results were found. CARCINOGENICITY Marsman et al. (1995) conducted a 2-year study in which groups of 80 male rats/group received Chlorophene orally at doses of 30, 60, or 120 mg/kg body weight a...; CITATION=75; 375; 30; CITATION_NUMBERS=[75,375,30]; REFERENCE=75; 375; 30; DETAILS_JSON={"cas_number":"97-23-4","citation":"75; 375; 30","dose":"The NOEL for developmental toxicity was 75 mg/kg/day.","duration":"2-year","effect":"d mucoid feces. The NOEL for developmental toxicity was 75 mg/kg/day. The developmental LOEL was 375 mg/kg/day based on a de- crease in mean fetal weight. Also in this report, New Zealand white rabbits were dosed with10,30,or100mg/kg/day.Acontrolgroupwasalsoincluded in the study. These doses were determined by a dose-finding study in which a 50% mortality rate occurred at 150 mg/kg/day and a 100% mortality rate occurred at 200 and 300 mg/kg/day. No maternal toxicity was observed at any dose, therefore the maternal NOEL was >100 mg/kg/day. Postimplantation loss was increased in the high-dose group compared to controls; however, litter sizes were comparable to controls. The NOEL and LOEL for developmental toxicity were 30 mg/kg/day and 100 mg/kg/day, respectively (EPA 1995). GENOTOXICITY Dichlorophene and Chlorophene genotoxicity studies are summarized in Table 3. Both positive and negative results were found. CARCINOGENICITY Marsman et al. (1995) conducted a 2-year study in which groups of 80 male rats/group received Chlorophene orally at doses of 30, 60, or 120 mg/kg body weight a...","endpoint":"developmental toxicity","ingredient":"Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a","loael_value":"","noael_unit":"mg/kg/day","noael_value":"> 100","page":17,"route":"","species":"rat","study_id":"PRS284_noael_008"} |
| Regulatory source | developmental toxicity | >900 | mg/kg/day | rat | oral | - | developmental toxicity | SOURCE_SUBDIR=PRS284; REPORT_TITLE=Safety Assessment of Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a; OPINION_NUMBER=PRS284; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=18 July 2003; VALUE_TEXT=> 900; DOSE=In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation.; EFFECT=namics, Inc. 1979). In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation. A control group was also included in the study. Rats had statistically significantly decreased body weight at all doses. Animals of the mid- and high-dose groups had de- creased mean feed consumption. Water intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, mortality, and increased mucoid feces. The NOEL for developmental toxicity was 75 mg/kg/day. The deve...; CITATION=100, 300; 900; 6; CITATION_NUMBERS=[100,300,900,6]; REFERENCE=100, 300; 900; 6; DETAILS_JSON={"cas_number":"97-23-4","citation":"100, 300; 900; 6","dose":"In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation.","duration":"","effect":"namics, Inc. 1979). In an EPA (1995) study, Chlorophene was given to Sprague- Dawley rats at doses of 100, 300, or 900 mg/kg/day on days 6 to 15 of gestation. A control group was also included in the study. Rats had statistically significantly decreased body weight at all doses. Animals of the mid- and high-dose groups had de- creased mean feed consumption. Water intake by the high-dose group was increased. The maternal NOEL was <100 mg/kg/day. Developmental effects were not observed, therefore the devel- opmental NOEL was >900 mg/kg/day. The same authors conducted a second rat developmental tox- icity study. Wistar rats were dosed orally with Chlorophene at 15, 75, or 375 mg/kg/day on days 6 to 15 post coitum. A con- trol group was also included in the study. Three of the dams in the 375-mg/kg/day dose group died. Decreased body weight gain and mucoid feces occurred. The NOEL for maternal tox- icity was 75 mg/kg/day. The LOEL was 375 mg/kg/day based on decreased body weight gain, mortality, and increased mucoid feces. The NOEL for developmental toxicity was 75 mg/kg/day. The deve...","endpoint":"developmental toxicity","ingredient":"Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a","loael_value":"","noael_unit":"mg/kg/day","noael_value":"> 900","page":17,"route":"oral","species":"rat","study_id":"PRS284_noael_006"} |
| Regulatory source | oral toxicity | 120 | mg/kg/day | rat | oral | 5 days | oral toxicity | SOURCE_SUBDIR=PRS284; REPORT_TITLE=Safety Assessment of Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a; OPINION_NUMBER=PRS284; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=18 July 2003; VALUE_TEXT=120; DOSE=Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively.; EFFECT=DICHLOROPHENE AND CHLOROPHENE 11 suppurative inflammation of the olfactory epithelium and were probably caused by the caustic nature of the compound and the gavage route of administration (NTP 1994). This study was also published by Marsman et al. (1995). Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively. A control group was also in- cluded in the study. In rats, the reported no-observable-effect level (NOEL) was 120 mg/kg/day and the lowest-observable ef- fect level (LOEL) was 240 mg/kg/day. A NOEL was not deter- mined for mice because renal lesions were present at the lowest dose tested (EPA 1995). Chronic Oral Toxicity Chlorophene In an NTP (1994) study, male and female rats (80/sex/group) were given Chlorophene in corn oil orally at doses of 30, 60, or 120 mg/kg and 60, 120, or 240 mg/kg, respectively, for 2 years. Male and female mice (70/sex/group) received Chlorophene orally at doses of 120, 240, or 480 mg/kg for 2 years. A con- trol group was included with each study. Rats were housed...; CITATION=11; 5; 13; CITATION_NUMBERS=[11,5,13]; REFERENCE=11; 5; 13; DETAILS_JSON={"cas_number":"97-23-4","citation":"11; 5; 13","dose":"Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively.","duration":"5 days","effect":"DICHLOROPHENE AND CHLOROPHENE 11 suppurative inflammation of the olfactory epithelium and were probably caused by the caustic nature of the compound and the gavage route of administration (NTP 1994). This study was also published by Marsman et al. (1995). Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively. A control group was also in- cluded in the study. In rats, the reported no-observable-effect level (NOEL) was 120 mg/kg/day and the lowest-observable ef- fect level (LOEL) was 240 mg/kg/day. A NOEL was not deter- mined for mice because renal lesions were present at the lowest dose tested (EPA 1995). Chronic Oral Toxicity Chlorophene In an NTP (1994) study, male and female rats (80/sex/group) were given Chlorophene in corn oil orally at doses of 30, 60, or 120 mg/kg and 60, 120, or 240 mg/kg, respectively, for 2 years. Male and female mice (70/sex/group) received Chlorophene orally at doses of 120, 240, or 480 mg/kg for 2 years. A con- trol group was included with each study. Rats were housed...","endpoint":"oral toxicity","ingredient":"Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a","loael_value":"","noael_unit":"mg/kg/day","noael_value":"120","page":11,"route":"oral","species":"rat","study_id":"PRS284_noael_001"} |
| Regulatory source | oral toxicity | 240 | mg/kg/day | rat | oral | 5 days | oral toxicity | SOURCE_SUBDIR=PRS284; REPORT_TITLE=Safety Assessment of Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a; OPINION_NUMBER=PRS284; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=18 July 2003; VALUE_TEXT=240; DOSE=Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively.; EFFECT=ctory epithelium and were probably caused by the caustic nature of the compound and the gavage route of administration (NTP 1994). This study was also published by Marsman et al. (1995). Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively. A control group was also in- cluded in the study. In rats, the reported no-observable-effect level (NOEL) was 120 mg/kg/day and the lowest-observable ef- fect level (LOEL) was 240 mg/kg/day. A NOEL was not deter- mined for mice because renal lesions were present at the lowest dose tested (EPA 1995). Chronic Oral Toxicity Chlorophene In an NTP (1994) study, male and female rats (80/sex/group) were given Chlorophene in corn oil orally at doses of 30, 60, or 120 mg/kg and 60, 120, or 240 mg/kg, respectively, for 2 years. Male and female mice (70/sex/group) received Chlorophene orally at doses of 120, 240, or 480 mg/kg for 2 years. A con- trol group was included with each study. Rats were housed five per cage and mice were housed individually. Survival of rats was...; CITATION=5; 13; 30, 60, 120, 240; CITATION_NUMBERS=[5,13,30,60,120,240]; REFERENCE=5; 13; 30, 60, 120, 240; DETAILS_JSON={"cas_number":"97-23-4","citation":"5; 13; 30, 60, 120, 240","dose":"Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively.","duration":"5 days","effect":"ctory epithelium and were probably caused by the caustic nature of the compound and the gavage route of administration (NTP 1994). This study was also published by Marsman et al. (1995). Rats and mice were dosed 5 days/week for 13 weeks at 30, 60, 120, 240, or 480 mg/kg/day and 500, 650, 800, or 1000 mg/kg/day, respectively. A control group was also in- cluded in the study. In rats, the reported no-observable-effect level (NOEL) was 120 mg/kg/day and the lowest-observable ef- fect level (LOEL) was 240 mg/kg/day. A NOEL was not deter- mined for mice because renal lesions were present at the lowest dose tested (EPA 1995). Chronic Oral Toxicity Chlorophene In an NTP (1994) study, male and female rats (80/sex/group) were given Chlorophene in corn oil orally at doses of 30, 60, or 120 mg/kg and 60, 120, or 240 mg/kg, respectively, for 2 years. Male and female mice (70/sex/group) received Chlorophene orally at doses of 120, 240, or 480 mg/kg for 2 years. A con- trol group was included with each study. Rats were housed five per cage and mice were housed individually. Survival of rats was...","endpoint":"oral toxicity","ingredient":"Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a","loael_value":"","noael_unit":"mg/kg/day","noael_value":"240","page":11,"route":"oral","species":"rat","study_id":"PRS284_noael_002"} |
| Regulatory source | repeated dose toxicity | 120 | mg/kg/day | rat | - | subchronic | repeated dose toxicity | SOURCE_SUBDIR=PRS284; REPORT_TITLE=Safety Assessment of Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a; OPINION_NUMBER=PRS284; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=18 July 2003; VALUE_TEXT=120 and 240; DOSE=At the high- est dose levels, microscopic evaluations in several studies re- vealed mild to moderate nephrosis and dilatation of the cecum in both species.; EFFECT=appeared more sensitive to Chlorophene than the mice, and male rats were more sensitive than female rats. At the high- est dose levels, microscopic evaluations in several studies re- vealed mild to moderate nephrosis and dilatation of the cecum in both species. In subchronic toxicity studies, all groups of rats fed 0.02% to 0.5% Dichlorophene had nephropathy at mi- croscopic examination. Rats had nephropathic changes when dosed with 480 mg/kg Chlorophene, and mice had nephro- pathic changes at all dose groups. The NOEL and LOEL of Chlorophene for rats were 120 and 240 mg/kg/day. Chronic tox- icity data were not available for Dichlorophene. Rats and mice dosed with Chlorophene for 2 years had a dose-related increase in the severity of nephropathy that appeared to be greater in males than females of each species. In ocular irritation studies, Dichlorophene was considered an irritant to the eye. In most ocular irritation studies, Chlorophene was considered very irritating to the eye. Dichlorophene up to 10% concentration resulted in no to minimal irritation when applied to the intact...; CITATION=0; 02; 5; CITATION_NUMBERS=[2,5]; REFERENCE=0; 02; 5; DETAILS_JSON={"cas_number":"97-23-4","citation":"0; 02; 5","dose":"At the high- est dose levels, microscopic evaluations in several studies re- vealed mild to moderate nephrosis and dilatation of the cecum in both species.","duration":"subchronic","effect":"appeared more sensitive to Chlorophene than the mice, and male rats were more sensitive than female rats. At the high- est dose levels, microscopic evaluations in several studies re- vealed mild to moderate nephrosis and dilatation of the cecum in both species. In subchronic toxicity studies, all groups of rats fed 0.02% to 0.5% Dichlorophene had nephropathy at mi- croscopic examination. Rats had nephropathic changes when dosed with 480 mg/kg Chlorophene, and mice had nephro- pathic changes at all dose groups. The NOEL and LOEL of Chlorophene for rats were 120 and 240 mg/kg/day. Chronic tox- icity data were not available for Dichlorophene. Rats and mice dosed with Chlorophene for 2 years had a dose-related increase in the severity of nephropathy that appeared to be greater in males than females of each species. In ocular irritation studies, Dichlorophene was considered an irritant to the eye. In most ocular irritation studies, Chlorophene was considered very irritating to the eye. Dichlorophene up to 10% concentration resulted in no to minimal irritation when applied to the intact...","endpoint":"repeated dose toxicity","ingredient":"Dichlorophene and Chlorophene1 Dichlorophene is a halogenated phenolic compound that func- tions as a bacteriocide and fungicide in cosmetics. Chlorophene is a halogenated phenolic compound that functions as a biocide a","loael_value":"","noael_unit":"mg/kg/day","noael_value":"120 and 240","page":24,"route":"","species":"rat","study_id":"PRS284_noael_010"} |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | T1J0JOU64O | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C13H10Cl2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T1J0JOU64O"} |
| openFDA substances | FDA UNII substance identifier | T1J0JOU64O | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C13H10Cl2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T1J0JOU64O"} |
| openFDA substances | FDA UNII substance identifier | T1J0JOU64O | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C13H10Cl2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T1J0JOU64O"} |
| openFDA substances | FDA UNII substance identifier | T1J0JOU64O | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C13H10Cl2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T1J0JOU64O"} |