NOAEL Studies Cosmetic Ingredient

Diamylhydroquinone NOAEL Studies

INCI: DIAMYLHYDROQUINONE

CAS: 79-74-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_10650; row=9369; data_type=In Vivo; mixture=Chemical; chemical_name=2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol; preferred_name=2,5-Bis(2-methylbutan-2-yl)benzene-1,4-diol; dtxsid=DTXSID5044992; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5044992; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 11.4 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2195; Record_ID=adme_parameters_844; Data_Type=Measured; DTXSID=DTXSID5044992; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=11.4; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5044992
NTP_ICE_adme_parameters Fu 0.0166 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2194; Record_ID=adme_parameters_844; Data_Type=Measured; DTXSID=DTXSID5044992; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0166; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5044992
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =150 mg/kg bw/day Rat oral - subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc399; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12704/7/6/2?documentUUID=a60b73c2-2d05-49bb-ab54-1ef242d56892; YEAR=1960; ORIGINAL_YEAR=1960; STUDY_GROUP=ECHA IUCLID:15836066:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_096a50e5a7e1fb33a35e4dd3f79c1ad4
ToxValDB_ECHA_IUCLID NOEL =70 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf1b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12704/7/9/3?documentUUID=a60b73c2-2d05-49bb-ab54-1ef242d56892; YEAR=1960; ORIGINAL_YEAR=1960; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821869:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_558a613e46efce0cdbfc2af613055e89
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =1.15 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631535:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b99f18757f04c35bab89bf180dae95d6
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 19O4J76TTK UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H26O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"19O4J76TTK"}
openFDA substances FDA UNII substance identifier 19O4J76TTK UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H26O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"19O4J76TTK"}
openFDA substances FDA UNII substance identifier 19O4J76TTK UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H26O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"19O4J76TTK"}
openFDA substances FDA UNII substance identifier 19O4J76TTK UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H26O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"19O4J76TTK"}