Is Diammonium Dithiodiglycolate safe in cosmetics?
Diammonium Dithiodiglycolate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Diammonium Dithiodiglycolate
INCI: DIAMMONIUM DITHIODIGLYCOLATE
Diammonium Dithiodiglycolate (CAS 68223-93-8) is a cosmetic cosmetic ingredient functioning as Hair waving or straightening (reducing agent / disulfide bond breaker). NOAEL 13 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 68223-93-8 →
Auto-generated CPSR Part A draft with source citations
Function
Hair waving or straightening (reducing agent / disulfide bond breaker)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
diazanium;2-(carboxylatomethyldisulfanyl)acetate
InChIKey
RZOXALOSBVDYRY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted — no specific CFR ban, but FDA monitors thioglycolates; labeling cautions apply
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diammonium Dithiodiglycolate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diammonium Dithiodiglycolate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Hair waving or straightening
Expert Verdict
Expert safety assessment and concern-level summary for Diammonium Dithiodiglycolate.
Regulatory Flags
potential-allergen
Chemical Function
Hair waving or straightening
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Diammonium Dithiodiglycolate allowed in the EU?
Diammonium Dithiodiglycolate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diammonium Dithiodiglycolate do in cosmetics?
Diammonium Dithiodiglycolate functions as: Hair waving or straightening (reducing agent / disulfide bond breaker). It is classified as a cosmetic ingredient in our database. CAS number: 68223-93-8.
Is Diammonium Dithiodiglycolate used outside cosmetics?
Diammonium Dithiodiglycolate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diammonium Dithiodiglycolate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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