Name: Diallyldimethyl Ammonium Chloride (DADMAC) NOAEL Studies
Creator: Roots by Benda

NTP_ICE_acute_oral 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_acute_oral	LD50	=3930	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9874; row=7425; data_type=In Vivo; mixture=Chemical; chemical_name=Dimethyldiallylammonium chloride; preferred_name=Diallyldimethylammonium chloride; dtxsid=DTXSID4027650; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027650; source_file=acute_oral.xlsx
NTP_ICE_acute_oral	LD50	>10000	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	record_id=acute_oral_9876; row=7426; data_type=In Vivo; mixture=Chemical; chemical_name=Dimethyldiallylammonium chloride; preferred_name=Diallyldimethylammonium chloride; dtxsid=DTXSID4027650; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027650; source_file=acute_oral.xlsx
NTP_ICE_acute_oral	LD50	=2520	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_9872; row=7427; data_type=In Vivo; mixture=Chemical; chemical_name=Dimethyldiallylammonium chloride; preferred_name=Diallyldimethylammonium chloride; dtxsid=DTXSID4027650; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027650; source_file=acute_oral.xlsx

NTP_ICE_endocrine 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_endocrine	Model Score	0	unitless	-	-	-	ARPathway2016; AR Pathway Model, Antagonist	sheet=Integrated_approaches; excel_row=7580; RecordID=ARPathway2016_1522; DatasetName=ARPathway2016; DTXSID=DTXSID4027650; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027650

ToxValDB_ECHA_IUCLID 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_ECHA_IUCLID	LOAEL	=800	mg/kg bw/day	Dog	oral	subchronic; 13 weeks	subchronic	QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae4ee4b0a7c65d1c8a67; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14101/7/6/2?documentUUID=f75a888e-1b5c-44eb-8422-3998b017b596; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843555_15849504:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4b309af5a78412cb44a464683c39aad7
ToxValDB_ECHA_IUCLID	NOAEL	=200	mg/kg bw/day	Dog	oral	subchronic; 13 weeks	subchronic	QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae4ee4b0a7c65d1c8a67; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14101/7/6/2?documentUUID=f75a888e-1b5c-44eb-8422-3998b017b596; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843555_15849504:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3282e2fbed7e9b609685d43ecfb43704

ToxValDB_HPVIS 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_HPVIS	LOAEL	=500	mg/kg bw/day	Rat	oral	subchronic; 90 days	subchronic	LONG_REF=Sterner, W. (1976). 13 Weeks Oral Toxicity Feeding Study with Monomer in Rats.International Bioresearch Laboratories, Hanover, Germany.Data extracted from the initial Robust Summary posted to the HPV Challenge Program website May 13, 2004.; QUALITY=3; EXTERNAL_SOURCE_ID=60398; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639597_15640043:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af3f571af8ecafbf6e96dd631b360a41
ToxValDB_HPVIS	NOAEL	=50	mg/kg bw/day	Rat	oral	subchronic; 90 days	subchronic	LONG_REF=Sterner, W. (1976). 13 Weeks Oral Toxicity Feeding Study with Monomer in Rats.International Bioresearch Laboratories, Hanover, Germany.Data extracted from the initial Robust Summary posted to the HPV Challenge Program website May 13, 2004.; QUALITY=3; EXTERNAL_SOURCE_ID=63519; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639597_15640043:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c4730b8834418d2afb61ae7acce41330
ToxValDB_HPVIS	NOAEL	=6	mg/kg bw/day	Rat	oral	short-term; 9 days	reproduction developmental	LONG_REF=Palmer, K. (1991). Poly (dimethyl diallyl ammonium chloride) (PDADMAC) -Oral (Gavage) Rat Teratology Study. Toxicol Laboratories, Ltd., Ledbury, UK.Data extracted from the initial Robust Summaries posted to the HPV Challenge Program website May 13, 2004 and Feb. 1, 2006.; QUALITY=1; EXTERNAL_SOURCE_ID=59592; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=HPVIS:15642795:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_68de9e7fa3a1e00e397ab1e03071570d
ToxValDB_HPVIS	NOAEL	=1.25	mg/kg bw/day	Rat	oral	chronic; 133 days	reproduction developmental	LONG_REF=Adamik, E. (1979). Segment I Multigeneration Study in Rats with Cat Floe T. Wil Research Laboratories, Cincinnati, OH.Data extracted from the initial Robust Summary posted to the HPV Challenge Program website May 13, 2004.; QUALITY=1; EXTERNAL_SOURCE_ID=65510; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=HPVIS:15643258:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e432ccb1cbfd9b7a6e616ca88f465d05

openFDA substances 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
openFDA substances	FDA UNII substance identifier	8MC08B895B	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C8H16N.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8MC08B895B"}
openFDA substances	FDA UNII substance identifier	8MC08B895B	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C8H16N.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8MC08B895B"}
openFDA substances	FDA UNII substance identifier	8MC08B895B	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C8H16N.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8MC08B895B"}
openFDA substances	FDA UNII substance identifier	8MC08B895B	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C8H16N.Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8MC08B895B"}