Is Diacetin safe in cosmetics?
Diacetin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Diacetin
Also known as: 1,2,3-Propanetriol, diacetate, Acetin, di-, Diacetylglycerol, Estol 1582, 1,3-Di(acetate) de glycerol (+11 more)
INCI: GLYCERYL DIACETATE
Diacetin (CAS 25395-31-7) is a cosmetic cosmetic ingredient functioning as Solvent, plasticizer, humectant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 25395-31-7 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent, plasticizer, humectant
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — GRAS as food additive (21 CFR 184.1505); not restricted in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diacetin.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Solvent
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Diacetin.
Regulatory Flags
ifra_fragrance
Known Synonyms
1,2,3-Propanetriol, diacetate
Acetin, di-
Diacetylglycerol
Estol 1582
1,3-Di(acetate) de glycerol
glycerol 1,3-di(acetate)
Glycerin-1,3-di(acetat)
1,3-di(acetato) de glicerol
Glyceryl diacetate, Diacetin
1,2,3-Propanetriol diacetate
Estol 1583
EINECS 246-941-2
Glycerin diacetate
Glycerine diacetate
Glycerol diacetate
UNII-GJ0544W99Q
Chemical Function
Solvent
Fragrance
Regulatory Lists
IFRA Transparency
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Diacetin allowed in the EU?
Diacetin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diacetin do in cosmetics?
Diacetin functions as: Solvent, plasticizer, humectant. It is classified as a cosmetic ingredient in our database. CAS number: 25395-31-7.
Compliance Tools
Check Diacetin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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