NOAEL Studies Cosmetic Ingredient

DI(T-BUTYLCYCLOHEXYL) PEROXYDICARBONATE NOAEL Studies

CAS: 15520-11-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_3046; row=14666; data_type=In Vivo; mixture=Chemical; chemical_name=Peroxydicarbonic acid, C,C'-bis[4-(1,1-dimethylethyl)cyclohexyl] ester; preferred_name=Peroxydicarbonic acid, C,C'-bis[4-(1,1-dimethylethyl)cyclohexyl] ester; dtxsid=DTXSID8065907; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8065907; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =1000 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead8ae4b0a7c65d1c4b84; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13939/7/6/2?documentUUID=a6f95c9d-3503-4499-9257-9e65ce7b1b0b; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15829922_15850845:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ab4fcb803eee6ce8defa1cfc3bbbf39d
ToxValDB_ECHA_IUCLID LOAEL =100 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead8ae4b0a7c65d1c4b92; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13939/7/6/2?documentUUID=a6f95c9d-3503-4499-9257-9e65ce7b1b0b; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=kidney: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15850847:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_19c10dcb8cc73412f1b5223d5feea149
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc700; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13939/7/9/3?documentUUID=a6f95c9d-3503-4499-9257-9e65ce7b1b0b; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15824395:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_42c082f1c19180a2e37a33f350cd324e
ToxValDB_ECHA_IUCLID NOAEL =500 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead8ae4b0a7c65d1c4b84; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13939/7/6/2?documentUUID=a6f95c9d-3503-4499-9257-9e65ce7b1b0b; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15829922_15850845:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3b9cfdb90d3ccb7681302e519f0f80cc
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =5.87 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630161:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f2f1d894fe15a35cb093712e72be7768
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 076NU497LZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H38O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"076NU497LZ"}
openFDA substances FDA UNII substance identifier 076NU497LZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H38O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"076NU497LZ"}
openFDA substances FDA UNII substance identifier 076NU497LZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H38O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"076NU497LZ"}
openFDA substances FDA UNII substance identifier 076NU497LZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C22H38O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"076NU497LZ"}