Is Deoxyribonuclease safe in cosmetics?
Deoxyribonuclease has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Deoxyribonuclease
INCI: DEOXYRIBONUCLEASE
Deoxyribonuclease (CAS 9003-98-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning enzyme; cleaves DNA in dead cells to aid exfoliation. NOAEL 1012.8 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 9003-98-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Deoxyribonuclease is classified GHS Danger (H334) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning enzyme; cleaves DNA in dead cells to aid exfoliation
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not prohibited under 21 CFR Parts 250/700; TSCA-listed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Deoxyribonuclease.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Deoxyribonuclease. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1012.8 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Deoxyribonuclease across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Deoxyribonuclease.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Deoxyribonuclease by CAS number or substance name.
Studies
1
Lowest NOAEL
1012.8 mg/kg bw/day
Highest NOAEL
1012.8 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Chemical Function
Softener and conditioner
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Deoxyribonuclease allowed in the EU?
Deoxyribonuclease EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Deoxyribonuclease do in cosmetics?
Deoxyribonuclease functions as: Skin conditioning enzyme; cleaves DNA in dead cells to aid exfoliation. It is classified as a cosmetic ingredient in our database. CAS number: 9003-98-9.
What is the NOAEL for Deoxyribonuclease?
The NOAEL (No Observed Adverse Effect Level) for Deoxyribonuclease is =1012.8 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Deoxyribonuclease used outside cosmetics?
Deoxyribonuclease also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Deoxyribonuclease have different safety status in cosmetics vs industrial chemicals?
Deoxyribonuclease is classified GHS Danger (H334) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Deoxyribonuclease compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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