NOAEL Studies Cosmetic Ingredient

Deoxycholic Acid NOAEL Studies

INCI: DEOXYCHOLIC ACID

CAS: 83-44-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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FDA_Toxicity_9e579a2f-b906-4468-a974-d217a6a58dba_dossier.i6z 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
FDA_Toxicity_9e579a2f-b906-4468-a974-d217a6a58dba_dossier.i6z NOAEL =50 mg/kg bw/day rat (Sprague-Dawley; male/female) unspecified 6 months repeated dose toxicity other 9e579a2f-b906-4468-a974-d217a6a58dba_dossier.i6z - RepeatedDoseToxicityOther - Repeat-dose toxicity studies of up to 6 months duration in rats and 9 months duration in dogs_3 - 4f16927b-7fb5-4135-bee2-517d9c2b4a29/5dd3addc-438f-4177-b42e-6cba9e4fc6c1 - basis: haematology: increased plasma cell number
FDA_Toxicity_9e579a2f-b906-4468-a974-d217a6a58dba_dossier.i6z NOAEL =50 mg/kg bw/day rat (Sprague-Dawley; male/female) unspecified 6 months repeated dose toxicity other 9e579a2f-b906-4468-a974-d217a6a58dba_dossier.i6z - RepeatedDoseToxicityOther - Repeat-dose toxicity studies of up to 6 months duration in rats and 9 months duration in dogs_3 - 4f16927b-7fb5-4135-bee2-517d9c2b4a29/5dd3addc-438f-4177-b42e-6cba9e4fc6c1 - basis: haematology: increased plasma cell number
FDA_Toxicity_9e579a2f-b906-4468-a974-d217a6a58dba_dossier.i6z NOAEL =50 mg/kg bw/day rat (Sprague-Dawley; male/female) unspecified 6 months repeated dose toxicity other 9e579a2f-b906-4468-a974-d217a6a58dba_dossier.i6z - RepeatedDoseToxicityOther - Repeat-dose toxicity studies of up to 6 months duration in rats and 9 months duration in dogs_3 - 4f16927b-7fb5-4135-bee2-517d9c2b4a29/5dd3addc-438f-4177-b42e-6cba9e4fc6c1 - basis: haematology: increased plasma cell number
FDA_Toxicity_9e579a2f-b906-4468-a974-d217a6a58dba_dossier.i6z NOAEL =50 mg/kg bw/day rat (Sprague-Dawley; male/female) unspecified 6 months repeated dose toxicity other 9e579a2f-b906-4468-a974-d217a6a58dba_dossier.i6z - RepeatedDoseToxicityOther - Repeat-dose toxicity studies of up to 6 months duration in rats and 9 months duration in dogs_3 - 4f16927b-7fb5-4135-bee2-517d9c2b4a29/5dd3addc-438f-4177-b42e-6cba9e4fc6c1 - basis: haematology: increased plasma cell number
ToxValDB_ECHA_IUCLID 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL >=5 mg/kg bw/day Rat oral chronic; 6 months chronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c62039e4b096bca878085d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=5dd3addc-438f-4177-b42e-6cba9e4fc6c1; TOXICOLOGICAL_EFFECT=injection site inflammation; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Other_15852237_15852238:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d54eb1ebb32a1f0a3812107d6574e3ae
ToxValDB_ECHA_IUCLID LEL =50 mg/kg bw/day Rat oral short-term; 4 weeks short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c620e3e4b096bca87830c6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=5dd3addc-438f-4177-b42e-6cba9e4fc6c1; TOXICOLOGICAL_EFFECT=abnormal body weight|abnormal food intake|dermatologic disorders|injection site inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15854344:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_54316467b796e21af11f3f9386145668
ToxValDB_ECHA_IUCLID NOAEL =50 mg/kg bw/day Rat oral chronic; 6 months chronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c62039e4b096bca878085d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=5dd3addc-438f-4177-b42e-6cba9e4fc6c1; TOXICOLOGICAL_EFFECT=increased plasma cell number; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Other_15852237_15852238:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e77b80d1e732d819ea94c0f6bfbdb94a
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 005990WHZZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C24H40O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"005990WHZZ"}
openFDA substances FDA UNII substance identifier 005990WHZZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C24H40O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"005990WHZZ"}
openFDA substances FDA UNII substance identifier 005990WHZZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C24H40O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"005990WHZZ"}
openFDA substances FDA UNII substance identifier 005990WHZZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C24H40O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"005990WHZZ"}