NOAEL Studies Cosmetic Ingredient

Delta-Decalactone NOAEL Studies

INCI: DELTA-DECALACTONE

CAS: 705-86-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 343 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 250 mg/kg bw/day dog oral 266 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =112 mg/kg bw/day Rat oral: gavage 730 days chronic/long term toxicity EFSA FEEDAP - 2012 - OutputID 616 - mortality - systemic - Scientific Opinion on the safety and efficacy of primary aliphatic saturated or unsaturated alcohols/aldehydes/acids/acetals/esters with a second primary, secondary or tertiary oxygenated functional group including aliphatic lactones (chemical group 9) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2928
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9747; Record_ID=skin_sensitization_invivo_2160; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0044496; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80099-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044496
NTP_ICE_skin_sensitization Induction dose per skin area 675 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9746; Record_ID=skin_sensitization_invivo_2160; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0044496; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=675; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80099-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044496
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=9749; Record_ID=skin_sensitization_invivo_2160; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0044496; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80099-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044496
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =112 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of primary aliphatic saturated or unsaturated alcohols/aldehydes/acids/acetals/esters with a second primary, secondary or tertiary oxygenated functional group including aliphatic lactones (chemical group 9) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2928.; TITLE=Scientific Opinion on the safety and efficacy of primary aliphatic saturated or unsaturated alcohols/aldehydes/acids/acetals/esters with a second primary, secondary or tertiary oxygenated functional group including aliphatic lactones (chemical group 9) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2928; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EFSA:15614735:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ff8cc970e673733c23717327f855a3f3
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =49.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630941:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a41f66450c6a78d7726f1118ca123dce
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier CNA0S5T234 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"CNA0S5T234"}
openFDA substances FDA UNII substance identifier CNA0S5T234 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"CNA0S5T234"}
openFDA substances FDA UNII substance identifier CNA0S5T234 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"CNA0S5T234"}
openFDA substances FDA UNII substance identifier CNA0S5T234 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"CNA0S5T234"}