Is Dehydroxanthan Gum safe in cosmetics?
Dehydroxanthan Gum has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Dehydroxanthan Gum
Also known as: Xanthan gum, EINECS 234-394-2, Gum xanthan, UNII-TTV12P4NEE
INCI: DEHYDROXANTHAN GUM
Dehydroxanthan Gum (CAS 11138-66-2) is a cosmetic cosmetic ingredient functioning as Emulsion Stabilizing, Film Forming, Hair Fixing, Viscosity Controlling,. Reported NOAEL =20 mg/kg in rat (CIR_vision_codex); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 11138-66-2 →
Auto-generated CPSR Part A draft with source citations
Function
Emulsion Stabilizing, Film Forming, Hair Fixing, Viscosity Controlling, Suspending
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR 2012/2016 safe as used (34-ingredient microbial polysaccharide gum class). Parent xanthan gum has GRAS status.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dehydroxanthan Gum.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Dehydroxanthan Gum. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =20 mg/kg | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =20 mg/kg | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =20 mg/kg | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =20 mg/kg | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =100 mg/kg BW/d | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =100 mg/kg BW/d | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =100 mg/kg BW/d | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =100 mg/kg BW/d | oral | rat | oral toxicity | CIR_vision_codex |
| NOAEL | =2000 mg/kg BW | oral | rat | reproductive toxicity | CIR_vision_codex |
| NOAEL | =2000 mg/kg BW | oral | rat | reproductive toxicity | CIR_vision_codex |
EPA ToxValDB — Toxicity Values
1 toxicity value from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LEL | =214 mg/kg-day | Human | oral | short-term | EFSA |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-caking agent
Binder
Degradant/impurity
Drier
Dye
Emulsifier
Filler
Film former
Fixing agent (mordant)
Flavouring and nutrient
Regulatory List Membership (5)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Dehydroxanthan Gum.
Regulatory Flags
eu_children_restricted
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dehydroxanthan Gum by CAS number or substance name.
Studies
12
Lowest NOAEL
20
Highest NOAEL
2000
Units vary across source rows: mg/kg BW, mg/kg BW/d, mg/kg
CIR_vision_codex
Known Synonyms
Xanthan gum
EINECS 234-394-2
Gum xanthan
UNII-TTV12P4NEE
Chemical Function
Viscosity modifier
Binder
Thickening agent
Dye
Surfactant (surface active agent)
Film former
Softener and conditioner
Emulsifier
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
children; Europe; Personal care
children; Europe; Personal care - general moisturizing - hand/body lotion
children; Europe; Personal care - dental care - toothpaste
children; Europe; Personal care
animal_products
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
IFRA Transparency
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Dehydroxanthan Gum allowed in the EU?
Dehydroxanthan Gum EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dehydroxanthan Gum do in cosmetics?
Dehydroxanthan Gum functions as: Emulsion Stabilizing, Film Forming, Hair Fixing, Viscosity Controlling, Suspending. It is classified as a cosmetic ingredient in our database. CAS number: 11138-66-2.
What is the NOAEL for Dehydroxanthan Gum?
The NOAEL (No Observed Adverse Effect Level) for Dehydroxanthan Gum is =20 mg/kg based on a oral toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: CIR_vision_codex.
Is Dehydroxanthan Gum used outside cosmetics?
Dehydroxanthan Gum also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dehydroxanthan Gum compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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