Is Darutoside safe in cosmetics?
Darutoside has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Darutoside
INCI: DARUTOSIDE
Darutoside (CAS 59219-65-7) is a cosmetic cosmetic ingredient functioning as Triterpenoid glycoside from Siegesbeckia orientalis with skin-conditioning,. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 59219-65-7 →
Auto-generated CPSR Part A draft with source citations
Function
Triterpenoid glycoside from Siegesbeckia orientalis with skin-conditioning, anti-stretch mark, firming, and repair activity.
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2R,3R,4S,5S,6R)-2-[[(2R,4aS,4bR,7S,10aS)-7-[(1R)-1,2-dihydroxyethyl]-1,1,4a,7-tetramethyl-3,4,4b,5,6,9,10,10a-octahydro-2H-phenanthren-2-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
InChIKey
QWWPCQGHWWNGET-LCVVDEIYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not monographed by FDA; considered an active cosmetic ingredient and must not be marketed with drug claims unless compliant with drug regulations. Supplier SDS flags it as toxic and pharmaceutically active for research use only, which a CPSR must reconcile with cosmetic purity and grade.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Darutoside.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Darutoside.
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL4105670
Frequently Asked Questions
Is Darutoside allowed in the EU?
Darutoside EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Darutoside do in cosmetics?
Darutoside functions as: Triterpenoid glycoside from Siegesbeckia orientalis with skin-conditioning, anti-stretch mark, firming, and repair activity.. It is classified as a cosmetic ingredient in our database. CAS number: 59219-65-7.
Is Darutoside used outside cosmetics?
Darutoside also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Darutoside compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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