NOAEL Studies Cosmetic Ingredient

Cystine NOAEL Studies

INCI: CYSTINE

CAS: 56-89-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rabbit oral 5 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1500 mg/kg bw/day rat oral 6 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1792 mg/kg bw/day rat oral 6 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1875 mg/kg bw/day rat oral 6 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1958 mg/kg bw/day rat oral 6 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2000 mg/kg bw/day rat oral 6 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2083 mg/kg bw/day rat oral 6 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2500 mg/kg bw/day cat oral 365 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3500 mg/kg bw/day rat oral 6 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5000 mg/kg bw/day rat oral 43 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5230 mg/kg bw/day rat oral 42 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 6000 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL ca.600 mg/kg bw/day rat oral: gavage - sub-chronic toxicity: oral dossier=6aed5137-430d-4a45-985f-7e7adf2c5824.i6z; document=92492244-ccfd-4696-8434-4e066170e128_6aed5137-430d-4a45-985f-7e7adf2c5824.i6d; document_key=92492244-ccfd-4696-8434-4e066170e128/6aed5137-430d-4a45-985f-7e7adf2c5824; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; key_result=false; entry_uuid=e3b2d51a-a71f-4b82-b564-84cbb8753ce5
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL ca.600 mg/kg bw/day rat oral: gavage - sub-chronic toxicity: oral dossier=6aed5137-430d-4a45-985f-7e7adf2c5824.i6z; document=92492244-ccfd-4696-8434-4e066170e128_6aed5137-430d-4a45-985f-7e7adf2c5824.i6d; document_key=92492244-ccfd-4696-8434-4e066170e128/6aed5137-430d-4a45-985f-7e7adf2c5824; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; key_result=false; entry_uuid=e3b2d51a-a71f-4b82-b564-84cbb8753ce5
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL ca.600 mg/kg bw/day rat oral: gavage - sub-chronic toxicity: oral dossier=6aed5137-430d-4a45-985f-7e7adf2c5824.i6z; document=92492244-ccfd-4696-8434-4e066170e128_6aed5137-430d-4a45-985f-7e7adf2c5824.i6d; document_key=92492244-ccfd-4696-8434-4e066170e128/6aed5137-430d-4a45-985f-7e7adf2c5824; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; key_result=false; entry_uuid=e3b2d51a-a71f-4b82-b564-84cbb8753ce5
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >25000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_7731; row=4841; data_type=In Vivo; mixture=Chemical; chemical_name=L-Cystine; preferred_name=L-Cystine; dtxsid=DTXSID2046418; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2046418; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL ~600 mg/kg bw/day Rat oral chronic; 93 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c93c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18810/7/6/2?documentUUID=6aed5137-430d-4a45-985f-7e7adf2c5824; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID:15839394:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2e5a7fbb1ad43b4b6ac5a7e41b2f2edc
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 48TCX9A1VT UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12N2O4S2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"48TCX9A1VT"}
openFDA substances FDA UNII substance identifier 48TCX9A1VT UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12N2O4S2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"48TCX9A1VT"}
openFDA substances FDA UNII substance identifier 48TCX9A1VT UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12N2O4S2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"48TCX9A1VT"}
openFDA substances FDA UNII substance identifier 48TCX9A1VT UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H12N2O4S2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"48TCX9A1VT"}