Is Cyclo(Prolylproline) safe in cosmetics?
Cyclo(Prolylproline) has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Cyclo(Prolylproline)
INCI: CYCLO(PROLYLPROLINE)
Cyclo(Prolylproline) (CAS 3446‑89‑7 (commonly cited for cyclo(L‑Pro‑L‑Pro)); individual cosmetic grade materials may use supplier‑specific identifiers (screening judgement)) is a cosmetic cosmetic ingredient functioning as Skin-conditioning / anti-aging peptide; may influence extracellular matrix and. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
3446‑89‑7 (commonly cited for cyclo(L‑Pro‑L‑Pro)); individual cosmetic grade materials may use supplier‑specific identifiers (screening judgement)
View industrial chemical safety profile →
Function
Skin-conditioning / anti-aging peptide; may influence extracellular matrix and firmness by peptide signaling
Safety Rating
MODERATE
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
No specific FDA monograph; used as cosmetic active ingredient; safety substantiation and impurity/stability control required
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cyclo(Prolylproline).
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Cyclo(Prolylproline).
Frequently Asked Questions
Is Cyclo(Prolylproline) allowed in the EU?
Cyclo(Prolylproline) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Cyclo(Prolylproline) do in cosmetics?
Cyclo(Prolylproline) functions as: Skin-conditioning / anti-aging peptide; may influence extracellular matrix and firmness by peptide signaling. It is classified as a cosmetic ingredient in our database. CAS number: 3446‑89‑7 (commonly cited for cyclo(L‑Pro‑L‑Pro)); individual cosmetic grade materials may use supplier‑specific identifiers (screening judgement).
Compliance Tools
Check Cyclo(Prolylproline) compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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