NOAEL Studies
Cosmetic Ingredient
Cyclohexanone NOAEL Studies
INCI: CYCLOHEXANONE
CAS: 108-94-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | LOAEL | 143 | mg/kg bw/day | rat | oral | 90 day | Subchronic | REACH; study report |
| COSMOS_DB | LOAEL | 910 | mg/kg bw/day | rat | oral | 2 year | Chronic | REACH;IRIS; J. Natl. Cancer Inst. 77(4): 941-949 |
| COSMOS_DB | LOAEL | 6500 | ppm | mouse | oral | 2 year | Chronic | REACH;IRIS; J. Natl. Cancer Inst. 77(4): 941-949 |
| COSMOS_DB | NOAEL | 40 | mg/kg bw/day | rat | oral | 90 day | Subchronic | REACH; study report |
| COSMOS_DB | NOAEL | 462 | mg/kg bw/day | rat | oral | 2 year | Chronic | REACH;IRIS; J. Natl. Cancer Inst. 77(4): 941-949 |
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 910 | mg/kg bw/day | other: | oral: drinking water | - | chronic toxicity: oral | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=821c3ec1-f354-4761-ad24-1a4cc8344dcb_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=821c3ec1-f354-4761-ad24-1a4cc8344dcb/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=791a5cb5-9d4b-4274-aba5-7230b854d8a3 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 910 | mg/kg bw/day | other: | oral: drinking water | - | chronic toxicity: oral | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=821c3ec1-f354-4761-ad24-1a4cc8344dcb_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=821c3ec1-f354-4761-ad24-1a4cc8344dcb/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=791a5cb5-9d4b-4274-aba5-7230b854d8a3 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 910 | mg/kg bw/day | other: | oral: drinking water | - | chronic toxicity: oral | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=821c3ec1-f354-4761-ad24-1a4cc8344dcb_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=821c3ec1-f354-4761-ad24-1a4cc8344dcb/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=791a5cb5-9d4b-4274-aba5-7230b854d8a3 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 250 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=97d2a6d1-6ecf-4d2d-988f-acdc6b7cfbca_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=97d2a6d1-6ecf-4d2d-988f-acdc6b7cfbca/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-06; basis=body weight and weight gain; key_result=false; entry_uuid=d5638060-b604-45a1-b588-2edec111e208 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 500 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=97d2a6d1-6ecf-4d2d-988f-acdc6b7cfbca_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=97d2a6d1-6ecf-4d2d-988f-acdc6b7cfbca/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-06; basis=other:; key_result=false; entry_uuid=90d3c383-08a4-46c4-9572-65f20bc7545b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | intravenous | - | short-term repeated dose toxicity: other route | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=ded8d277-3901-4fa9-8e84-55555d52f8c3_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=ded8d277-3901-4fa9-8e84-55555d52f8c3/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=false; entry_uuid=f1c40fe9-dfe7-4997-b696-b62b044c028e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 143 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=9179a215-0272-423d-a16c-ae8554979f1d_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=9179a215-0272-423d-a16c-ae8554979f1d/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-14; basis=other:; key_result=false; entry_uuid=5c442db2-bf52-4109-97de-72429c810134 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 462 | mg/kg bw/day | other: | oral: drinking water | - | chronic toxicity: oral | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=821c3ec1-f354-4761-ad24-1a4cc8344dcb_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=821c3ec1-f354-4761-ad24-1a4cc8344dcb/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=b0216f0c-9b04-48c8-826c-7a40257af29c |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 250 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=97d2a6d1-6ecf-4d2d-988f-acdc6b7cfbca_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=97d2a6d1-6ecf-4d2d-988f-acdc6b7cfbca/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-06; basis=body weight and weight gain; key_result=false; entry_uuid=d5638060-b604-45a1-b588-2edec111e208 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 500 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=97d2a6d1-6ecf-4d2d-988f-acdc6b7cfbca_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=97d2a6d1-6ecf-4d2d-988f-acdc6b7cfbca/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-06; basis=other:; key_result=false; entry_uuid=90d3c383-08a4-46c4-9572-65f20bc7545b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | intravenous | - | short-term repeated dose toxicity: other route | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=ded8d277-3901-4fa9-8e84-55555d52f8c3_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=ded8d277-3901-4fa9-8e84-55555d52f8c3/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=false; entry_uuid=f1c40fe9-dfe7-4997-b696-b62b044c028e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 143 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=9179a215-0272-423d-a16c-ae8554979f1d_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=9179a215-0272-423d-a16c-ae8554979f1d/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-14; basis=other:; key_result=false; entry_uuid=5c442db2-bf52-4109-97de-72429c810134 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 462 | mg/kg bw/day | other: | oral: drinking water | - | chronic toxicity: oral | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=821c3ec1-f354-4761-ad24-1a4cc8344dcb_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=821c3ec1-f354-4761-ad24-1a4cc8344dcb/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=b0216f0c-9b04-48c8-826c-7a40257af29c |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 250 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=97d2a6d1-6ecf-4d2d-988f-acdc6b7cfbca_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=97d2a6d1-6ecf-4d2d-988f-acdc6b7cfbca/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-06; basis=body weight and weight gain; key_result=false; entry_uuid=d5638060-b604-45a1-b588-2edec111e208 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 500 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=97d2a6d1-6ecf-4d2d-988f-acdc6b7cfbca_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=97d2a6d1-6ecf-4d2d-988f-acdc6b7cfbca/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-06; basis=other:; key_result=false; entry_uuid=90d3c383-08a4-46c4-9572-65f20bc7545b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | intravenous | - | short-term repeated dose toxicity: other route | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=ded8d277-3901-4fa9-8e84-55555d52f8c3_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=ded8d277-3901-4fa9-8e84-55555d52f8c3/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=RepeatedDoseToxicityOther; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=false; entry_uuid=f1c40fe9-dfe7-4997-b696-b62b044c028e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 143 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=9179a215-0272-423d-a16c-ae8554979f1d_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=9179a215-0272-423d-a16c-ae8554979f1d/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-07-14; basis=other:; key_result=false; entry_uuid=5c442db2-bf52-4109-97de-72429c810134 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 462 | mg/kg bw/day | other: | oral: drinking water | - | chronic toxicity: oral | dossier=b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6z; document=821c3ec1-f354-4761-ad24-1a4cc8344dcb_b301fa8c-6c51-44fc-8fe7-c6e6604091ae.i6d; document_key=821c3ec1-f354-4761-ad24-1a4cc8344dcb/b301fa8c-6c51-44fc-8fe7-c6e6604091ae; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1986; basis=other:; key_result=false; entry_uuid=b0216f0c-9b04-48c8-826c-7a40257af29c |
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfd_systems.csv | NOAEL | =462 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=206ecc66b0cca617; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 4.62e2 mg/kg-day; system=Other; basis=Body weight depression; point_of_departure=NOAEL : 4.62e2 mg/kg-day; composite_uf=100; confidence=Medium; dtxsid=DTXSID6020359; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=219; rfd_last_updated=09/30/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0219_summary.pdf |
| EPA_IRIS_iris_rfd_systems.csv | RfD | =5 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=34a52ba5c461bf08; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=5; system=Other; basis=Body weight depression; point_of_departure=NOAEL : 4.62e2 mg/kg-day; composite_uf=100; confidence=Medium; dtxsid=DTXSID6020359; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=219; rfd_last_updated=09/30/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0219_summary.pdf |
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"} |
NTP_ICE_acute_inhalation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 32.0929 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3300; Record_ID=acute_inhalation_1150; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6020359; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=32.0929; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020359; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020359 |
| NTP_ICE_acute_inhalation | LC50 | 19 | mg/L | - | Inhalation | - | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3301; Record_ID=acute_inhalation_1612; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6020359; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=19; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020359; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020359 |
NTP_ICE_cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=6394; Record_ID=cancer_5165; Data_Type=WOE; Formulation_Name=Cyclohexanone; Mixture=Chemical; DTXSID=DTXSID6020359; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/65; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020359; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020359 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=7166; RecordID=ARPathway2016_522; DatasetName=ARPathway2016; DTXSID=DTXSID6020359; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020359; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020359 |
NTP_ICE_eye_irritation 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1783; Record_ID=eye_irritation_236; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID6020359; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020359; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020359 |
| NTP_ICE_eye_irritation | Intensity | 0.26 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1782; Record_ID=eye_irritation_1274; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6020359; Assay=Vitrigel; Endpoint=Intensity; Response=0.26; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020359; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020359 |
| NTP_ICE_eye_irritation | Lag time | 10 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1785; Record_ID=eye_irritation_1274; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6020359; Assay=Vitrigel; Endpoint=Lag time; Response=10; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020359; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020359 |
| NTP_ICE_eye_irritation | Plateau level | 48 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1784; Record_ID=eye_irritation_1274; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6020359; Assay=Vitrigel; Endpoint=Plateau level; Response=48; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020359; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020359 |
NTP_ICE_skin_sensitization 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3365; Record_ID=skin_sensitization_invivo_852; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6020359; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020359; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020359 |
| NTP_ICE_skin_sensitization | Relative reliability score | 5 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3369; Record_ID=skin_sensitization_invivo_852; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Mixture=Chemical; DTXSID=DTXSID6020359; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=5; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020359; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020359 |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =44155.4 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15514026:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d28ce6841ccd4031d4466f662bd9033f |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | NOEL | =800 | mg/kg bw/day | Mouse | oral | short-term (developmental); 5 days | reproduction developmental | LONG_REF=Teratog. Carcinog. Mutagen.4:403-426 Gray,L.E.,Jr., and R.J. Kavlock An Extended Evaluation of an In Vivo Teratology Screen Utilizing Postnatal Growth and Viability in the Mouse 1984; TITLE=An Extended Evaluation of an In Vivo Teratology Screen Utilizing Postnatal Growth and Viability in the Mouse; AUTHOR=Gray,L.E.,Jr., and R.J. Kavlock; DOI=10.1002/tcm.1770040504; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=65506; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Development: Age at first reproduction|Reproduction: Progeny counts/numbers|Growth: Weight|Morphology: Weight|Reproduction: Pregnant females in a population|Reproduction: Progeny counts/numbers|Mortality: Survival|Reproduction: Vaginal opening; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|development|mortality/survival|other|reproduction; STUDY_GROUP=ECOTOX:15611607:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=c4bc3b0829af8d100ce405b090559d27 |
ToxValDB_EU_SCOEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EU_SCOEL | LOAEL | =762.685 | mg/m3 | Rabbit | inhalation | subchronic; 10 weeks | subchronic | LONG_REF=Treon, J.F., Crutchfield, W.E. Jr and Kitzmiller, K.V. (1943). The physiological response of animals to cyclohexane, methylcyclohexane and derivatives of these compounds. J. Ind. Hyg. Toxicol. 25. 323-347.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d39a9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/016_cyclohexanone_oel_en.pdf; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic effects; STUDY_GROUP=EU SCOEL:15952379:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b3c856529155f527e5af4b86b8e4ab19 |
| ToxValDB_EU_SCOEL | NOAEL | =100.353 | mg/m3 | Human | inhalation | acute; 5 minutes | clinical | LONG_REF=Nelson, K.W., Ege, J.F., Ross, M.Jr., Woodman, L.E. and Silverman, L. (1943). Sensory response to certain industrial solvent vapours. J. Ind. Hyg. Toxicol. 25, 282.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d39a9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/016_cyclohexanone_oel_en.pdf; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=irritation to the throat and eye; STUDY_GROUP=EU SCOEL:15952380:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_793c544ee755be4683f55ab89e45c669 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =10 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630873_15630874:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e24a17661f9be4a7f16e0337673fb27f |
ToxValDB_IRIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_IRIS | LOAEL | =910 | mg/kg bw/day | Rat | oral | chronic | chronic | LONG_REF=Lijinsky, W. and M. Kovatch. 1986. A chronic toxicity study of cyclohexanone in rats and mice (NCI study). J. Natl. Cancer Inst. 77(4): 941-949.; TITLE=A chronic toxicity study of cyclohexanone in rats and mice (NCI study); AUTHOR=Lijinsky, W. and M. Kovatch; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a53bb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=219; TOXICOLOGICAL_EFFECT=body weight depression; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=IRIS_dup_IRIS Summary_15644650_15644651:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_780d003eb1566f7f43d5957c2ed5c669 |
| ToxValDB_IRIS | NOAEL | =462 | mg/kg bw/day | Rat | oral | chronic | chronic | LONG_REF=Lijinsky, W. and M. Kovatch. 1986. A chronic toxicity study of cyclohexanone in rats and mice (NCI study). J. Natl. Cancer Inst. 77(4): 941-949.; TITLE=A chronic toxicity study of cyclohexanone in rats and mice (NCI study); AUTHOR=Lijinsky, W. and M. Kovatch; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a53bb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=219; TOXICOLOGICAL_EFFECT=body weight depression; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=IRIS_dup_IRIS Summary_15644650_15644651:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c87c27b50255c8e5c2853f4b7274b138 |
| ToxValDB_IRIS | RfD | =5 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Lijinsky, W. and M. Kovatch. 1986. A chronic toxicity study of cyclohexanone in rats and mice (NCI study). J. Natl. Cancer Inst. 77(4): 941-949.; TITLE=A chronic toxicity study of cyclohexanone in rats and mice (NCI study); AUTHOR=Lijinsky, W. and M. Kovatch; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a53bb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=219; TOXICOLOGICAL_EFFECT=Body weight depression in male/female rats; STUDY_GROUP=IRIS:15644652:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bd863d678bf1f33355e57d1e7a6dfabc |
ToxValDB_PPRTV_(CPHEA) 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_PPRTV_(CPHEA) | NOAEL | =731 | mg/kg bw/day | Rat | oral | chronic; 25 weeks | chronic | LONG_REF=Lijinsky and Kavatch 1986; AUTHOR=Lijinsky and Kavatch; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3a9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1660; TOXICOLOGICAL_EFFECT=reduced body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=PPRTV (CPHEA):15654097:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_655235849fadf68ddd7672fa6bf4cf76 |
| ToxValDB_PPRTV_(CPHEA) | NOAEL (HEC) | =222 | mg/m3 | Rabbit | inhalation | short-term; 3 weeks | short-term | LONG_REF=Treon et al. 1943; AUTHOR=Treon et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3a9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1660; TOXICOLOGICAL_EFFECT=adverse clinical signs (salivation, conjunctival congestion and irritation, lacrimation, lethargy); TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=PPRTV (CPHEA):15653508:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_28c3798c99949db59638ac1da7b1329c |
| ToxValDB_PPRTV_(CPHEA) | RfC (provisional) | =7 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Treon et al. 1943; AUTHOR=Treon et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3a9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1660; TOXICOLOGICAL_EFFECT=Adverse clinical signs (salivation, conjunctival congestion and irritation, lacrimation, lethargy) in rabbits; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653506_15653507:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c44609f4010465865efa5f395dee4f11 |
| ToxValDB_PPRTV_(CPHEA) | RfD (provisional) | =2 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Lijinsky and Kavatch 1986; AUTHOR=Lijinsky and Kavatch; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b3a9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1660; TOXICOLOGICAL_EFFECT=Decreased body weight gain in male rats; STUDY_GROUP=PPRTV (CPHEA):15653809:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6f71cddf6defa46c466296da96aa77e4 |
ToxValDB_Pennsylvania_DEP_ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Pennsylvania_DEP_ToxValues | RfC | =0.7 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15649967:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bf5831816d306dd8a9df002c441543d1 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 5QOR3YM052 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5QOR3YM052"} |
| openFDA substances | FDA UNII substance identifier | 5QOR3YM052 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5QOR3YM052"} |
| openFDA substances | FDA UNII substance identifier | 5QOR3YM052 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5QOR3YM052"} |
| openFDA substances | FDA UNII substance identifier | 5QOR3YM052 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5QOR3YM052"} |