NOAEL Studies Cosmetic Ingredient

CYCLOHEXANE DIMETHANOL NOAEL Studies

CAS: 105-08-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14211/7/9/3?documentUUID=26420239-67eb-4519-814b-08f3bf1afa13; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: clinical signs|maternal: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival; STUDY_GROUP=ECHA IUCLID:15823932:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3552109541df4af830accbdcf9451c3c
ToxValDB_ECHA_IUCLID NOAEL =200 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3b9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14211/7/9/3?documentUUID=26420239-67eb-4519-814b-08f3bf1afa13; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=maternal: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID:15823934:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fe1eb387495b989bebd6b42d727bd334
ToxValDB_ECHA_IUCLID NOAEL =400 mg/kg bw/day Rabbit oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3b9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14211/7/9/3?documentUUID=26420239-67eb-4519-814b-08f3bf1afa13; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15823935:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b8b19c957434ff2f0115a4364840357d
ToxValDB_ECHA_IUCLID NOAEL =5 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b5595; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/14211?documentUUID=53a6ce9f-bdcf-49e4-9638-50c28b3543dd; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID:15860587:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_11a871910e4501c2071fbc05c2c38168
ToxValDB_ECHA_IUCLID NOAEL =700 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b5590; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14211/7/9/2?documentUUID=26420239-67eb-4519-814b-08f3bf1afa13; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=F1: viability|F1: gross pathology|F1: histopathology: non-neoplastic|F1: |F1: sexual maturation|F1: clinical signs|F1: mortality|F1: body weight and weight gain|F1: food consumption and compound intake|F1: haematology|F1: clinical biochemistry|F1: urinalysis|F1: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|development|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|reproduction|urinalysis; STUDY_GROUP=ECHA IUCLID:15862483:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9a9cc7c681ad66d89cfde117c6e55f12
ToxValDB_ECHA_IUCLID NOEL =854 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b5593; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14211/7/9/2?documentUUID=26420239-67eb-4519-814b-08f3bf1afa13; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=F1: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15862487:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_25e3c4e6ea2d4791c4d2ff201d4b339a
ToxValDB_EPA_TSCA_8e 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EPA_TSCA_8e LEL =400 mg/kg bw/day Rabbit oral short-term (developmental); 12 days reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20728_373201.pdf; TOXICOLOGICAL_EFFECT=mortality, clinical signs, abortion; STUDY_GROUP=EPA TSCA 8e_dup_-_15956255_15956256:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c495f245c1c80b0ce0b32087dd4c860d
ToxValDB_EPA_TSCA_8e LEL =800 mg/kg bw/day Rabbit oral short-term (developmental); 12 days reproduction developmental STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20728_373201.pdf; TOXICOLOGICAL_EFFECT=clinical signs, macroscopic findings in the lung, kidney, stomach, and vagina; STUDY_GROUP=EPA TSCA 8e_dup_-_15956255_15956256:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0a7a810f390501df7be40a55d0b1c60d
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =30.4 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630886:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8837153a63b5e3cc2da372651f70978f
openFDA substances 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8C3FKR6R1B UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"8C3FKR6R1B"}
openFDA substances FDA UNII substance identifier 8C3FKR6R1B UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"8C3FKR6R1B"}
openFDA substances FDA UNII substance identifier 8C3FKR6R1B UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"8C3FKR6R1B"}