Is Cyclic Adenosine Diphosphate Ribose (cADPR) safe in cosmetics?
Cyclic Adenosine Diphosphate Ribose (cADPR) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Cyclic Adenosine Diphosphate Ribose (cADPR)
INCI: CYCLIC ADENOSINE DIPHOSPHATE RIBOSE
Cyclic Adenosine Diphosphate Ribose (cADPR) (CAS 123548-30-9 (commonly cited for cADPR as a biochemical; cosmetic databases often omit CAS)) is a cosmetic cosmetic ingredient functioning as Skin-conditioning, cell-signaling modulator, anti-aging active; regulates. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
123548-30-9 (commonly cited for cADPR as a biochemical; cosmetic databases often omit CAS)
View industrial chemical safety profile →
Function
Skin-conditioning, cell-signaling modulator, anti-aging active; regulates intracellular calcium release
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA position; viewed as a novel cosmetic active; manufacturer must provide safety substantiation for intended concentration and exposure
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cyclic Adenosine Diphosphate Ribose (cADPR).
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Cyclic Adenosine Diphosphate Ribose (cADPR).
Frequently Asked Questions
Is Cyclic Adenosine Diphosphate Ribose (cADPR) allowed in the EU?
Cyclic Adenosine Diphosphate Ribose (cADPR) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cyclic Adenosine Diphosphate Ribose (cADPR) do in cosmetics?
Cyclic Adenosine Diphosphate Ribose (cADPR) functions as: Skin-conditioning, cell-signaling modulator, anti-aging active; regulates intracellular calcium release. It is classified as a cosmetic ingredient in our database. CAS number: 123548-30-9 (commonly cited for cADPR as a biochemical; cosmetic databases often omit CAS).
Compliance Tools
Check Cyclic Adenosine Diphosphate Ribose (cADPR) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acrylates/Vinyl Neodecanoate Crosspolymer
Excellent
Same category
Emulsion stabilising, film forming
Adipic Acid
Excellent
Same category
Buffering
Aluminum Magnesium Oxide
Excellent
Same category
Absorbent, bulking agent, opacifying ...
Ammonium VA/Acrylates Copolymer
Excellent
Same category
Antistatic, binding, film forming, ha...
Ammonium VA/Crotonic Acid Copolymer
Excellent
Same category
Antistatic, film forming, hair fixing...
Aphanothece Sacrum Polysaccharide
Excellent
Same category
Absorbent, emulsion stabilising, film...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
CYCLIC ADENOSINE DIPHOSPHATE RIBOSE
Good
Browse nearby
Hair Conditioning, Skin Conditioning,...
CYCLOHEXANE DIMETHANOL
Good
Browse nearby
Not Reported
CYCLOHEXYL METHACRYLATE
Good
Browse nearby
Film Forming
Is Cyclic Adenosine Diphosphate Ribose (cADPR) in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Cyclic Adenosine Diphosphate Ribose (cADPR) in your formulation.