Is Cucurbitacin B safe in cosmetics?
Cucurbitacin B has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Cucurbitacin B
INCI: CUCURBITACIN B
Cucurbitacin B (CAS 6199-67-3) is a cosmetic cosmetic ingredient functioning as Skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 6199-67-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Cucurbitacin B is classified GHS Danger (H300) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
[(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate
InChIKey
IXQKXEUSCPEQRD-DKRGWESNSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically prohibited or restricted; the FDA does not maintain a positive list for cosmetic ingredients, so the manufacturer bears responsibility for safety substantiation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cucurbitacin B.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Cucurbitacin B.
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL508185
Frequently Asked Questions
Is Cucurbitacin B allowed in the EU?
Cucurbitacin B EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cucurbitacin B do in cosmetics?
Cucurbitacin B functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 6199-67-3.
Is Cucurbitacin B used outside cosmetics?
Cucurbitacin B also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Cucurbitacin B have different safety status in cosmetics vs industrial chemicals?
Cucurbitacin B is classified GHS Danger (H300) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Cucurbitacin B compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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