NOAEL Studies Cosmetic Ingredient

Coriandrum Sativum Fruit Oil NOAEL Studies

INCI: CORIANDRUM SATIVUM FRUIT OIL

CAS: 8008-52-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 6000 mg/kg bw/day rat oral 70 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx NOAEL =450 mg/kg bw/day Rat oral: gavage 91 days subchronic ENDPOINTSTUDY_ID 696259; TOX_ID 6958 - OP_ID 2415 - EFSA NDA - 2013 - Scientific Opinion on the safety of 'coriander seed oil' as a Novel Food ingredient. - doi:10.2903/j.efsa.2013.3422
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx NOAEL =450 mg/kg bw/day Rat oral: gavage 91 days subchronic ENDPOINTSTUDY_ID 696259; TOX_ID 6958 - OP_ID 2415 - EFSA NDA - 2013 - Scientific Opinion on the safety of 'coriander seed oil' as a Novel Food ingredient. - doi:10.2903/j.efsa.2013.3422
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=12145; Record_ID=skin_sensitization_invivo_2642; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX971; Formulation_Name=Coriander oil; Concentration=6.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID80858864; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90150-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID80858864
NTP_ICE_skin_sensitization Induction dose per skin area 3888 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=12144; Record_ID=skin_sensitization_invivo_2642; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX971; Formulation_Name=Coriander oil; Concentration=6.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID80858864; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=3888; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90150-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID80858864
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=12149; Record_ID=skin_sensitization_invivo_2642; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX971; Formulation_Name=Coriander oil; Concentration=6.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID80858864; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90150-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID80858864
ToxValDB_ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX NOEL =50 mg/kg bw/day Mouse injection acute; 0.0474 days acute LONG_REF=J. Agric. Food Chem.30(3): 563-568 Marcus,C., and E.P. Lichtenstein Interactions of Naturally Occurring Food Plant Components with Insecticides and Pentobarbital in Rats and Mice 1982; TITLE=Interactions of Naturally Occurring Food Plant Components with Insecticides and Pentobarbital in Rats and Mice; AUTHOR=Marcus,C., and E.P. Lichtenstein; DOI=10.1021/jf00111a038; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=111962; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Behavior: Sleeping time, induced; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX:15598599:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b1b4b93af0a4144112d901bb9cbfe42a
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 7626GC95E5 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"7626GC95E5"}
openFDA substances FDA UNII substance identifier 7626GC95E5 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"7626GC95E5"}
openFDA substances FDA UNII substance identifier 7626GC95E5 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"7626GC95E5"}
openFDA substances FDA UNII substance identifier 7626GC95E5 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"7626GC95E5"}