Is Copper Sulfate safe in cosmetics?
Copper Sulfate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Copper Sulfate
INCI: COPPER SULFATE
Copper Sulfate (CAS C4H8CuN2O4) is a cosmetic cosmetic ingredient functioning as Tier 3 — Recommended for Robust Dossier. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS C4H8CuN2O4 →
Auto-generated CPSR Part A draft with source citations
Function
Tier 3 — Recommended for Robust Dossier
Safety Rating
MODERATE
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
FDA reviewed by CIR as part of the Inorganic Sulfates group. CIR Panel concluded inorganic sulfates (including copper sulfate) are safe as used in cosmetics at reported concentrations. FDA also lists copper powder as a color additive exempt from certification.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Copper Sulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Copper Sulfate based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
metal
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
Source: ESSCA 2019/20; NACDG 2021-22
Additional Ingredient Properties
2 property records from structured ingredient metadata.
acne
{"cas_number": "7758-98-7", "anti_acne_mechanism": "antibacterial/anti_inflammatory", "comedogenicity_rating_0_to_5": "1", "acne_type_efficacy": "inflammatory", "p_acnes_mic_ug_per_ml": ">500", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_…
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "metal", "patch_test_frequency_pct": "0.3", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "ESSCA 2019/20; NACDG 2021-22"}
Expert Verdict
Expert safety assessment and concern-level summary for Copper Sulfate.
Regulatory Flags
endocrine_disruptor
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Copper Sulfate by CAS number or substance name.
Studies
9
Lowest NOAEL
3.8 mg/kg bw/day
Highest NOAEL
185 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Frequently Asked Questions
Is Copper Sulfate allowed in the EU?
Copper Sulfate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Copper Sulfate do in cosmetics?
Copper Sulfate functions as: Tier 3 — Recommended for Robust Dossier. It is classified as a cosmetic ingredient in our database. CAS number: C4H8CuN2O4.
Compliance Tools
Check Copper Sulfate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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