Good Cosmetic Ingredient NOAEL Data GHS Classified

COLOPHONIUM

Also known as: Gum rosin, Bandis G100, Caswell No. 667, EINECS 232-475-7, EPA Pesticide Chemical Code 067205 (+5 more)

COLOPHONIUM (CAS 8050-09-7) is a cosmetic cosmetic ingredient functioning as Binding, Depilatory, Film Forming, Viscosity Controlling. NOAEL 10 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.

View industrial chemical safety profile for CAS 8050-09-7 →

Auto-generated CPSR Part A draft with source citations
Function
Binding, Depilatory, Film Forming, Viscosity Controlling
Safety Rating
GOOD

Chemistry & Identifiers

EC Number
232-475-7

Regulatory Status

EU EU Status permitted
US US Status Not specifically regulated

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Toxicological Studies

1 study endpoint found for COLOPHONIUM. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =480 mg/kg bw/day oral Rat subchronic ToxValDB_ECHA_IUCLID

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma.
Routes of Exposure
The substance can be absorbed into the body by inhalation of fume.

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for COLOPHONIUM across SCCS product categories, with measured dermal absorption where available.

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Adhesion/cohesion promoter Binder Depilatory Dye Film former Flavouring and nutrient Fragrance Pigment Surfactant (surface active agent) Thickening agent
Regulatory List Membership (3)
FDA Substances Added to Food (EAFUS) FDA Indirect Food Contact Additives Consumer Product Chemical

Expert Verdict

Expert safety assessment and concern-level summary for COLOPHONIUM.

Regulatory Flags

cosing-sourced eu-permitted needs-enrichment fda_food_additive

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to COLOPHONIUM by CAS number or substance name.

Studies
1
Lowest NOAEL
480 mg/kg bw/day
Highest NOAEL
480 mg/kg bw/day
ToxValDB_ECHA_IUCLID

Known Synonyms

Gum rosin Bandis G100 Caswell No. 667 EINECS 232-475-7 EPA Pesticide Chemical Code 067205 Rondis R UNII-88S87KL877 Gum Rosin WW EC No.: 232-475-7 232-475-7

Chemical Function

Film former Viscosity modifier Binder Depilatory Thickening agent

Regulatory Lists

consumer_product; Europe detected; Europe; Other direct contact consumer goods detected; Europe; Other direct contact consumer goods detected; Europe; Other direct contact consumer goods Europe; nondetect; Other direct contact consumer goods consumer_product drinking_water; Europe; manufacturing; plastic_additive Europe; plastic_additive Canada; pharmaceutical inert_ingredient; non_food_use; Pesticides food_additive; Substances Added to Food (formerly EAFUS) (2/2019) CEDI CEDI Indirect additives food contact (10/2018)

Australian Status

AICIS status: listed

Frequently Asked Questions

Is COLOPHONIUM safe in cosmetics?

COLOPHONIUM has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.

Is COLOPHONIUM allowed in the EU?

COLOPHONIUM EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does COLOPHONIUM do in cosmetics?

COLOPHONIUM functions as: Binding, Depilatory, Film Forming, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 8050-09-7.

What is the NOAEL for COLOPHONIUM?

The NOAEL (No Observed Adverse Effect Level) for COLOPHONIUM is =480 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.

Is COLOPHONIUM used outside cosmetics?

COLOPHONIUM also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

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