Also known as: N,N-Dimethyl-N-(3-(coconut oil alkyl)amidopropyl)amine oxide, EINECS 268-938-5, N-(3-(Dimethylamino)propyl) coco amides N-oxides, UNII-M4SL82J7HK
INCI: COCAMIDOPROPYLAMINE OXIDE
Cocamidopropylamine Oxide (CAS 68155-09-9) is a cosmetic cosmetic ingredient functioning as Surfactant (cleansing), surfactant (foam boosting), surfactant (hydrotrope),. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; 4 safety opinions reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
US NotesFDA: Not restricted. CIR Reviewed (2008 Amended Final Report): Safe in rinse-off products. Insufficient data for leave-on products.
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Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cocamidopropylamine Oxide.
Calculate MoS for your specific formulation with the
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Toxicological Studies
1 study endpoint found for Cocamidopropylamine Oxide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=1000 mg/kg bw/day
oral
Rat
short-term
ToxValDB_ECHA_IUCLID
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir25 July 2007
Verdict: unknown
NOAEL: 15 mg/kg (oral)
cir25 July 2007
Verdict: unknown
NOAEL: 15 mg/kg/day (dermal)
cir25 July 2007
Verdict: unknown
NOAEL: 1000 mg/kg (oral)
cir25 July 2007
Verdict: unknown
NOAEL: 150 mg/kg (dermal)
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Cocamidopropylamine Oxide across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
Surfactant (surface active agent)Solubility enhancerCleaning agentSoftener and conditioner
Regulatory Lists
Europe; Personal care - body hygiene - hand soapchildren; Europe; Personal careEurope; Personal care - hair styling and care - shampoo-dandruffSCIL (9/2019)fracking; waterinert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status:listed
Frequently Asked Questions
Is Cocamidopropylamine Oxide safe in cosmetics?
Cocamidopropylamine Oxide has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is Cocamidopropylamine Oxide allowed in the EU?
Cocamidopropylamine Oxide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cocamidopropylamine Oxide do in cosmetics?
Cocamidopropylamine Oxide functions as: Surfactant (cleansing), surfactant (foam boosting), surfactant (hydrotrope), hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 68155-09-9.
What is the NOAEL for Cocamidopropylamine Oxide?
The NOAEL (No Observed Adverse Effect Level) for Cocamidopropylamine Oxide is =1000 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Cocamidopropylamine Oxide used outside cosmetics?
Cocamidopropylamine Oxide also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Cocamidopropylamine Oxide have different safety status in cosmetics vs industrial chemicals?
Cocamidopropylamine Oxide is classified GHS Danger (H302, H315, H318, H373, H411) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
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