NOAEL Studies Cosmetic Ingredient

Citronellyl Formate NOAEL Studies

INCI: CITRONELLYL FORMATE

CAS: 105-85-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOEL =50 mg/kg bw/day Rat oral: feed 84 days subchronic EFSA FEEDAP - 2016 - OutputID 2864 - no adverse effect observed - Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4559
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOEL =50 mg/kg bw/day Rat oral: feed 84 days subchronic EFSA FEEDAP - 2016 - OutputID 2864 - no adverse effect observed - Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4559
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =8400 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_494; row=3159; data_type=In Vivo; mixture=Chemical; chemical_name=3,7-Dimethyloct-6-en-1-yl formate; preferred_name=Citronellyl formate; dtxsid=DTXSID1044772; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1044772; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2779; Record_ID=skin_sensitization_invivo_739; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1044772; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90257-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1044772
NTP_ICE_skin_sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2778; Record_ID=skin_sensitization_invivo_739; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1044772; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90257-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1044772
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2781; Record_ID=skin_sensitization_invivo_739; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1044772; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90257-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1044772
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =1000 mg/kg bw/day Rat oral short-term; 2 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca01e4b0a7c65d21fb80; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18137/7/6/2?documentUUID=ada4d591-02bc-418a-8d6b-ad34ce567e65; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=liver: clinical signs|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|other; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837992_15850285:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_13bb7ba8403d391161ae8f0eea386f81
ToxValDB_ECHA_IUCLID NOAEL =200 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b55a7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18137/7/9/2?documentUUID=ada4d591-02bc-418a-8d6b-ad34ce567e65; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID:15860911:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_84a7d81b3042730736868db19af11e6a
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat oral short-term; 2 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca01e4b0a7c65d21fb80; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18137/7/6/2?documentUUID=ada4d591-02bc-418a-8d6b-ad34ce567e65; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=liver: clinical signs|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|other; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837992_15850285:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_26175e4c447509a412ec8f103266ef38
ToxValDB_ECHA_IUCLID NOAEL =800 mg/kg bw/day Rat oral subchronic; 49 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c0a27; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18137/7/6/2?documentUUID=ada4d591-02bc-418a-8d6b-ad34ce567e65; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID:15850286:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_37a67b7ce14b713750f26ba6794da730
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOEL =50 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4559.; TITLE=Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4559; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15624829:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3f248f596ee69ae94737556214d3b5c7
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =4.94 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630742:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0bbc7f97bd4f18ee83a213c1b01d5049
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 7B1MY2BRDK UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7B1MY2BRDK"}
openFDA substances FDA UNII substance identifier 7B1MY2BRDK UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7B1MY2BRDK"}
openFDA substances FDA UNII substance identifier 7B1MY2BRDK UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7B1MY2BRDK"}
openFDA substances FDA UNII substance identifier 7B1MY2BRDK UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7B1MY2BRDK"}