NOAEL Studies Cosmetic Ingredient

Citronellyl Acetate NOAEL Studies

INCI: CITRONELLYL ACETATE

CAS: 150-84-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOEL =50 mg/kg bw/day Rat oral: feed 84 days subchronic EFSA FEEDAP - 2016 - OutputID 2864 - no adverse effect observed - Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4559
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOEL =50 mg/kg bw/day Rat oral: feed 84 days subchronic EFSA FEEDAP - 2016 - OutputID 2864 - no adverse effect observed - Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4559
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5637; Record_ID=skin_sensitization_invivo_1304; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5051739; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90255-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5051739
NTP_ICE_skin_sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5636; Record_ID=skin_sensitization_invivo_1304; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5051739; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90255-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5051739
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5639; Record_ID=skin_sensitization_invivo_1304; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5051739; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90255-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5051739
ToxValDB_ECHA_IUCLID 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat dermal - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8cbe4b0a7c65d21a2e0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5472/7/9/2?documentUUID=8f65a091-635f-437d-be7d-c98b1a9c06f5; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15855562:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c8b6dd3cf01ed850a731493ba67f6d92
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b37c1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5472/7/8?documentUUID=8f65a091-635f-437d-be7d-c98b1a9c06f5; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819490_15820088:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6318c98376a8199ce23a941283f031c6
ToxValDB_ECHA_IUCLID NOAEL >2000 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b37c1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5472/7/8?documentUUID=8f65a091-635f-437d-be7d-c98b1a9c06f5; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819490_15820088:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a59647546113fa7fec4d857685bf031c
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOEL =50 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4559.; TITLE=Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4559; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15624827:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_451d978461b3f2f396587e4b4ea6c411
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =17 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630741:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4fece25146a1e4a022da3b891007c49c
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier IZ420RT3OY UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"IZ420RT3OY"}
openFDA substances FDA UNII substance identifier IZ420RT3OY UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"IZ420RT3OY"}
openFDA substances FDA UNII substance identifier IZ420RT3OY UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"IZ420RT3OY"}
openFDA substances FDA UNII substance identifier IZ420RT3OY UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"IZ420RT3OY"}