NOAEL Studies
Fragrance
Citronellol NOAEL Studies
INCI: CITRONELLOL
CAS: 106-22-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 24 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=85910d0d-0f89-4dd7-89a9-2e253cf7616f_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=85910d0d-0f89-4dd7-89a9-2e253cf7616f/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; basis=other:; key_result=false; entry_uuid=47e65ba0-d005-4327-b864-68e9562230bc |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >2000 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=5feaeba3-7ba3-4172-b336-3742b6a622bf_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=5feaeba3-7ba3-4172-b336-3742b6a622bf/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1987; key_result=false; entry_uuid=41254f1a-1425-4a8f-b79c-f157a413cdf8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 300 | mg/kg bw/day | rat | dermal | - | screening for reproductive / developmental toxicity | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=e794bdba-9da4-4191-bd87-f400adcbc06a_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=e794bdba-9da4-4191-bd87-f400adcbc06a/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-14; basis=other:; key_result=false; entry_uuid=44ccb4aa-86df-4b85-b2ea-adee5270bfaa |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >=750 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=45d40132-8074-4ec8-9a86-8fcf0d85954b_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=45d40132-8074-4ec8-9a86-8fcf0d85954b/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2016; basis=other:; key_result=false; entry_uuid=ee942b6a-e6ba-4cb8-b198-bd3e8a532f31 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=edac0214-df79-43fd-b1c6-559846b3bdbf_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=edac0214-df79-43fd-b1c6-559846b3bdbf/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; basis=other:; key_result=false; entry_uuid=8a1f790b-b187-43fe-a34b-be13a5b61e24 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=85910d0d-0f89-4dd7-89a9-2e253cf7616f_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=85910d0d-0f89-4dd7-89a9-2e253cf7616f/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; basis=other:; key_result=false; entry_uuid=47e65ba0-d005-4327-b864-68e9562230bc |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >2000 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=5feaeba3-7ba3-4172-b336-3742b6a622bf_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=5feaeba3-7ba3-4172-b336-3742b6a622bf/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1987; key_result=false; entry_uuid=41254f1a-1425-4a8f-b79c-f157a413cdf8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 300 | mg/kg bw/day | rat | dermal | - | screening for reproductive / developmental toxicity | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=e794bdba-9da4-4191-bd87-f400adcbc06a_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=e794bdba-9da4-4191-bd87-f400adcbc06a/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-14; basis=other:; key_result=false; entry_uuid=44ccb4aa-86df-4b85-b2ea-adee5270bfaa |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >=750 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=45d40132-8074-4ec8-9a86-8fcf0d85954b_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=45d40132-8074-4ec8-9a86-8fcf0d85954b/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2016; basis=other:; key_result=false; entry_uuid=ee942b6a-e6ba-4cb8-b198-bd3e8a532f31 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=edac0214-df79-43fd-b1c6-559846b3bdbf_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=edac0214-df79-43fd-b1c6-559846b3bdbf/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; basis=other:; key_result=false; entry_uuid=8a1f790b-b187-43fe-a34b-be13a5b61e24 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | mouse | oral: gavage | - | sub-chronic toxicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=85910d0d-0f89-4dd7-89a9-2e253cf7616f_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=85910d0d-0f89-4dd7-89a9-2e253cf7616f/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1987; basis=other:; key_result=false; entry_uuid=47e65ba0-d005-4327-b864-68e9562230bc |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >2000 | mg/kg bw/day | rat | oral: gavage | - | carcinogenicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=5feaeba3-7ba3-4172-b336-3742b6a622bf_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=5feaeba3-7ba3-4172-b336-3742b6a622bf/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=1987; key_result=false; entry_uuid=41254f1a-1425-4a8f-b79c-f157a413cdf8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 300 | mg/kg bw/day | rat | dermal | - | screening for reproductive / developmental toxicity | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=e794bdba-9da4-4191-bd87-f400adcbc06a_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=e794bdba-9da4-4191-bd87-f400adcbc06a/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; ReportDate=2010-10-14; basis=other:; key_result=false; entry_uuid=44ccb4aa-86df-4b85-b2ea-adee5270bfaa |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >=750 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=45d40132-8074-4ec8-9a86-8fcf0d85954b_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=45d40132-8074-4ec8-9a86-8fcf0d85954b/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2016; basis=other:; key_result=false; entry_uuid=ee942b6a-e6ba-4cb8-b198-bd3e8a532f31 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=edac0214-df79-43fd-b1c6-559846b3bdbf_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=edac0214-df79-43fd-b1c6-559846b3bdbf/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2010; basis=other:; key_result=false; entry_uuid=8a1f790b-b187-43fe-a34b-be13a5b61e24 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | >550 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=ab42f4e6-d397-4cc2-9d3d-d2ed79ee05a4_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=ab42f4e6-d397-4cc2-9d3d-d2ed79ee05a4/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1967; key_result=false; entry_uuid=17ec620a-39df-4b8d-b9aa-b24f28fd7baf |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 51 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=c935b8e6-3f1d-4a9b-88b2-ed612983f097_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=c935b8e6-3f1d-4a9b-88b2-ed612983f097/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2006; key_result=false; entry_uuid=f7062bc1-f2e1-4284-853c-0ca8b2979df2 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 56 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=c935b8e6-3f1d-4a9b-88b2-ed612983f097_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=c935b8e6-3f1d-4a9b-88b2-ed612983f097/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2006; key_result=false; entry_uuid=55d5f3cf-2c8f-497c-9abc-f6d0ca8b0b39 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | >550 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=ab42f4e6-d397-4cc2-9d3d-d2ed79ee05a4_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=ab42f4e6-d397-4cc2-9d3d-d2ed79ee05a4/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1967; key_result=false; entry_uuid=17ec620a-39df-4b8d-b9aa-b24f28fd7baf |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 51 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=c935b8e6-3f1d-4a9b-88b2-ed612983f097_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=c935b8e6-3f1d-4a9b-88b2-ed612983f097/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2006; key_result=false; entry_uuid=f7062bc1-f2e1-4284-853c-0ca8b2979df2 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 56 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=c935b8e6-3f1d-4a9b-88b2-ed612983f097_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=c935b8e6-3f1d-4a9b-88b2-ed612983f097/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2006; key_result=false; entry_uuid=55d5f3cf-2c8f-497c-9abc-f6d0ca8b0b39 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | >550 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=ab42f4e6-d397-4cc2-9d3d-d2ed79ee05a4_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=ab42f4e6-d397-4cc2-9d3d-d2ed79ee05a4/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1967; key_result=false; entry_uuid=17ec620a-39df-4b8d-b9aa-b24f28fd7baf |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 51 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=c935b8e6-3f1d-4a9b-88b2-ed612983f097_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=c935b8e6-3f1d-4a9b-88b2-ed612983f097/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2006; key_result=false; entry_uuid=f7062bc1-f2e1-4284-853c-0ca8b2979df2 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 56 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=59f1d6d4-5c21-4299-8127-e9819e6db50d.i6z; document=c935b8e6-3f1d-4a9b-88b2-ed612983f097_59f1d6d4-5c21-4299-8127-e9819e6db50d.i6d; document_key=c935b8e6-3f1d-4a9b-88b2-ed612983f097/59f1d6d4-5c21-4299-8127-e9819e6db50d; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2006; key_result=false; entry_uuid=55d5f3cf-2c8f-497c-9abc-f6d0ca8b0b39 |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOEL | =50 | mg/kg bw/day | Rat | oral: feed | 84 days | subchronic | EFSA FEEDAP - 2016 - OutputID 2864 - no adverse effect observed - Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4559 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOEL | =50 | mg/kg bw/day | Rat | oral: feed | 84 days | subchronic | EFSA FEEDAP - 2016 - OutputID 2864 - no adverse effect observed - Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4559 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=6638; RecordID=ARPathway2016_465; DatasetName=ARPathway2016; DTXSID=DTXSID3026726; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
NTP_ICE_skin_irritation 25 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | ET50 | 65.4 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=2509; Record_ID=skin_irritation_invitro_1388; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiDerm Irritation; Endpoint=ET50; Response=65.4; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | ET50 | 66.1 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=2510; Record_ID=skin_irritation_invitro_1389; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiDerm Irritation; Endpoint=ET50; Response=66.1; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | ET50 | 69.6 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=2511; Record_ID=skin_irritation_invitro_1390; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiDerm Irritation; Endpoint=ET50; Response=69.6; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | ET50 | 70 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=2512; Record_ID=skin_irritation_invitro_1391; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiDerm Irritation; Endpoint=ET50; Response=70; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | ET50 | 73.5 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=2513; Record_ID=skin_irritation_invitro_1392; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiDerm Irritation; Endpoint=ET50; Response=73.5; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | ET50 | 74.4 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=2514; Record_ID=skin_irritation_invitro_1393; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiDerm Irritation; Endpoint=ET50; Response=74.4; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | ET50 | 83 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=2515; Record_ID=skin_irritation_invitro_1394; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiDerm Irritation; Endpoint=ET50; Response=83; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | ET50 | 47.9 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=2531; Record_ID=skin_irritation_invitro_1386; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiDerm Irritation; Endpoint=ET50; Response=47.9; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | ET50 | 54.1 | min | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=2554; Record_ID=skin_irritation_invitro_1387; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiDerm Irritation; Endpoint=ET50; Response=54.1; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Positive reaction | 0 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=756; Record_ID=skin_irritation_invivo_42; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=0; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability | 4.2 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=2520; Record_ID=skin_irritation_invitro_278; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiSkin Irritation; Endpoint=Viability; Response=4.2; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability | 11 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=2522; Record_ID=skin_irritation_invitro_290; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiSkin Irritation; Endpoint=Viability; Response=11; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability | 11.4 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=2523; Record_ID=skin_irritation_invitro_291; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiSkin Irritation; Endpoint=Viability; Response=11.4; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability | 8 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=2524; Record_ID=skin_irritation_invitro_292; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiDerm Irritation; Endpoint=Viability; Response=8; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability | 8.7 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=2525; Record_ID=skin_irritation_invitro_293; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiDerm Irritation; Endpoint=Viability; Response=8.70; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability | 9.7 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=2526; Record_ID=skin_irritation_invitro_294; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiDerm Irritation; Endpoint=Viability; Response=9.70; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability | 10.4 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=2553; Record_ID=skin_irritation_invitro_289; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiSkin Irritation; Endpoint=Viability; Response=10.4; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability | 7.37 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=2555; Record_ID=skin_irritation_invitro_279; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiSkin Irritation; Endpoint=Viability; Response=7.37; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability | 10.5 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=2557; Record_ID=skin_irritation_invitro_281; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiSkin Irritation; Endpoint=Viability; Response=10.5; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability | 10.6 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=2558; Record_ID=skin_irritation_invitro_282; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiSkin Irritation; Endpoint=Viability; Response=10.6; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability | 12.3 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=2561; Record_ID=skin_irritation_invitro_285; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiDerm Irritation; Endpoint=Viability; Response=12.3; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability | 5.9 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=2562; Record_ID=skin_irritation_invitro_286; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiSkin Irritation; Endpoint=Viability; Response=5.9; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability | 7 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=2564; Record_ID=skin_irritation_invitro_288; Data_Type=In Vitro; Formulation_Name=dl-Citronellol; Concentration=98.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=EpiSkin Irritation; Endpoint=Viability; Response=7; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability (18 hours) | 4.7 | % | - | Dermal | - | In Vitro; Vitrolife-Skin Irritation | sheet=Data_invitro; excel_row=2527; Record_ID=skin_irritation_invitro_765; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (18 hours); Response=4.7; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_irritation | Viability (42 hours) | 3.8 | % | - | Dermal | - | In Vitro; Vitrolife-Skin Irritation | sheet=Data_invitro; excel_row=2529; Record_ID=skin_irritation_invitro_765; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (42 hours); Response=3.8; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
NTP_ICE_skin_sensitization 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD86, EC150 | 50.31 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; h-CLAT | sheet=Data_invitro; excel_row=1677; Record_ID=skin_sensitization_invitro_400; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=50.31; Reported_Response_Unit=ug/mL; Response=50.31; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 25.09 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8664; Record_ID=skin_sensitization_invitro_2397; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=25.09; Reported_Response_Unit=ug/mL; Response=25.09; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | CV70 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8663; Record_ID=skin_sensitization_invitro_2397; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | CV75 | 92.6 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; h-CLAT | sheet=Data_invitro; excel_row=1647; Record_ID=skin_sensitization_invitro_400; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=h-CLAT; Endpoint=CV75; Reported_Response=92.6; Reported_Response_Unit=ug/mL; Response=92.6; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | Depletion Cys | 14.4 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=67; Record_ID=skin_sensitization_invitro_39; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=14.4; Reported_Response_Unit=%; Response=14.4; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | Depletion Lys | 0 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=121; Record_ID=skin_sensitization_invitro_39; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | EC1.5 | 4000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4354; Record_ID=skin_sensitization_invitro_1012; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=4000; Reported_Response_Unit=uM; Response=4000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | EC3 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4356; Record_ID=skin_sensitization_invitro_1012; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=KeratinoSens; Endpoint=EC3; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | EC3 | 43.5 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13141; Record_ID=skin_sensitization_invivo_3159; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=LLNA; Endpoint=EC3; Response=43.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | IC50 | 375 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4358; Record_ID=skin_sensitization_invitro_1012; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=375; Reported_Response_Unit=uM; Response=375; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | Imax | 1.39 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4360; Record_ID=skin_sensitization_invitro_1012; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.39; Reported_Response_Unit=Unitless; Response=1.39; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=2930; Record_ID=skin_sensitization_invivo_776; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=6.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1975; Not available; 10.1016/0015-6264(75)90209-6|Hostynek and Maibach 2004; Not available; 10.1159/000092445|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640206; 10.1016/j.fct.2008.06.043|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 3724 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=2929; Record_ID=skin_sensitization_invivo_776; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=6.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=3724; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1975; Not available; 10.1016/0015-6264(75)90209-6|Hostynek and Maibach 2004; Not available; 10.1159/000092445|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640206; 10.1016/j.fct.2008.06.043|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 29530 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=2937; Record_ID=skin_sensitization_invivo_777; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=29530; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2005; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640206; 10.1016/j.fct.2008.06.043|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | Relative reliability score | 2 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=2935; Record_ID=skin_sensitization_invivo_776; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=6.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1975; Not available; 10.1016/0015-6264(75)90209-6|Hostynek and Maibach 2004; Not available; 10.1159/000092445|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640206; 10.1016/j.fct.2008.06.043|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=2940; Record_ID=skin_sensitization_invivo_777; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026726; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 2005; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Lapczynski et al. 2008; 18640206; 10.1016/j.fct.2008.06.043|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026726; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026726 |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOEL | =50 | mg/kg bw/day | Rat | oral | subchronic; 12 weeks | subchronic | LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4559.; TITLE=Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4559; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15621844:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e97bca6875e77006cbb803feafd9e092 |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =10 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630739_15630740:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_25ac521d27df40626cba8448edc58eb1 |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =161.6 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630739_15630740:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b27d222e97e6a9614c01157a047b4723 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 565OK72VNF | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"565OK72VNF"} |
| openFDA substances | FDA UNII substance identifier | 565OK72VNF | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"565OK72VNF"} |
| openFDA substances | FDA UNII substance identifier | 565OK72VNF | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"565OK72VNF"} |
| openFDA substances | FDA UNII substance identifier | 565OK72VNF | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"565OK72VNF"} |