NOAEL Studies Cosmetic Ingredient

Citronellal NOAEL Studies

INCI: CITRONELLAL

CAS: 106-23-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 33 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 210 mg/kg bw/day rat oral: feed - carcinogenicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=93782e77-b0dc-42ed-bf6a-d03360413876_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=93782e77-b0dc-42ed-bf6a-d03360413876/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=dc7ca3cd-8fcd-44be-8de7-cccbfd4a360f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 345 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=ed18535a-e010-4251-bcf6-0aa71fb40a81_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=ed18535a-e010-4251-bcf6-0aa71fb40a81/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=5823c2f4-e550-4a99-a013-ab5024601183
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 335 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=ed18535a-e010-4251-bcf6-0aa71fb40a81_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=ed18535a-e010-4251-bcf6-0aa71fb40a81/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=d57735aa-b9c6-4a55-8551-283c51bab01a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 745 mg/kg bw/day mouse oral: feed - sub-chronic toxicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=091be4eb-6275-4a2e-ba0e-20ef1336566e_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=091be4eb-6275-4a2e-ba0e-20ef1336566e/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=2801d06a-4b22-452c-b273-4bf73f20c19a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 790 mg/kg bw/day mouse oral: feed - sub-chronic toxicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=091be4eb-6275-4a2e-ba0e-20ef1336566e_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=091be4eb-6275-4a2e-ba0e-20ef1336566e/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=52aebd1f-5d00-40ed-ab1d-631c05b64449
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 120 mg/kg bw/day mouse oral: feed - carcinogenicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=ee6631a0-3f75-42ca-8094-dd22b3c250b6_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=ee6631a0-3f75-42ca-8094-dd22b3c250b6/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=05ae4faa-2464-4142-a1c3-7398cff84029
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 60 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=9bc4ae8f-3356-4dfd-9a66-6af0c9ed6c64_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=9bc4ae8f-3356-4dfd-9a66-6af0c9ed6c64/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=false; entry_uuid=ae4aeeae-7a19-4d87-bb1a-cf3e46656e0a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 210 mg/kg bw/day rat oral: feed - carcinogenicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=93782e77-b0dc-42ed-bf6a-d03360413876_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=93782e77-b0dc-42ed-bf6a-d03360413876/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=dc7ca3cd-8fcd-44be-8de7-cccbfd4a360f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 345 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=ed18535a-e010-4251-bcf6-0aa71fb40a81_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=ed18535a-e010-4251-bcf6-0aa71fb40a81/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=5823c2f4-e550-4a99-a013-ab5024601183
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 335 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=ed18535a-e010-4251-bcf6-0aa71fb40a81_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=ed18535a-e010-4251-bcf6-0aa71fb40a81/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=d57735aa-b9c6-4a55-8551-283c51bab01a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 745 mg/kg bw/day mouse oral: feed - sub-chronic toxicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=091be4eb-6275-4a2e-ba0e-20ef1336566e_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=091be4eb-6275-4a2e-ba0e-20ef1336566e/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=2801d06a-4b22-452c-b273-4bf73f20c19a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 790 mg/kg bw/day mouse oral: feed - sub-chronic toxicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=091be4eb-6275-4a2e-ba0e-20ef1336566e_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=091be4eb-6275-4a2e-ba0e-20ef1336566e/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=52aebd1f-5d00-40ed-ab1d-631c05b64449
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 120 mg/kg bw/day mouse oral: feed - carcinogenicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=ee6631a0-3f75-42ca-8094-dd22b3c250b6_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=ee6631a0-3f75-42ca-8094-dd22b3c250b6/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=05ae4faa-2464-4142-a1c3-7398cff84029
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 60 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=9bc4ae8f-3356-4dfd-9a66-6af0c9ed6c64_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=9bc4ae8f-3356-4dfd-9a66-6af0c9ed6c64/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=false; entry_uuid=ae4aeeae-7a19-4d87-bb1a-cf3e46656e0a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 210 mg/kg bw/day rat oral: feed - carcinogenicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=93782e77-b0dc-42ed-bf6a-d03360413876_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=93782e77-b0dc-42ed-bf6a-d03360413876/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=dc7ca3cd-8fcd-44be-8de7-cccbfd4a360f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 345 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=ed18535a-e010-4251-bcf6-0aa71fb40a81_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=ed18535a-e010-4251-bcf6-0aa71fb40a81/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=5823c2f4-e550-4a99-a013-ab5024601183
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 335 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=ed18535a-e010-4251-bcf6-0aa71fb40a81_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=ed18535a-e010-4251-bcf6-0aa71fb40a81/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=d57735aa-b9c6-4a55-8551-283c51bab01a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 745 mg/kg bw/day mouse oral: feed - sub-chronic toxicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=091be4eb-6275-4a2e-ba0e-20ef1336566e_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=091be4eb-6275-4a2e-ba0e-20ef1336566e/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=2801d06a-4b22-452c-b273-4bf73f20c19a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 790 mg/kg bw/day mouse oral: feed - sub-chronic toxicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=091be4eb-6275-4a2e-ba0e-20ef1336566e_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=091be4eb-6275-4a2e-ba0e-20ef1336566e/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=52aebd1f-5d00-40ed-ab1d-631c05b64449
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 120 mg/kg bw/day mouse oral: feed - carcinogenicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=ee6631a0-3f75-42ca-8094-dd22b3c250b6_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=ee6631a0-3f75-42ca-8094-dd22b3c250b6/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=05ae4faa-2464-4142-a1c3-7398cff84029
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 60 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=9bc4ae8f-3356-4dfd-9a66-6af0c9ed6c64_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=9bc4ae8f-3356-4dfd-9a66-6af0c9ed6c64/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1995; basis=other:; key_result=false; entry_uuid=ae4aeeae-7a19-4d87-bb1a-cf3e46656e0a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 100 mg/kg bw/day rat oral: feed - carcinogenicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=93782e77-b0dc-42ed-bf6a-d03360413876_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=93782e77-b0dc-42ed-bf6a-d03360413876/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=ff31afae-d5cc-4f91-b563-f5650e41eccf
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 60 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=a2f9ebf3-38fe-453c-8b38-fd89d1c2bc43_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=a2f9ebf3-38fe-453c-8b38-fd89d1c2bc43/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2016; basis=body weight and weight gain; key_result=true; entry_uuid=6777e7bf-f8bd-4a24-ab23-ec76eb34a24f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 200 mg/kg bw/day - - - one-generation reproductive toxicity dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=f51493e9-6ba0-4b36-a6b8-32d91346f9e2_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=f51493e9-6ba0-4b36-a6b8-32d91346f9e2/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=ToxicityReproduction; basis=other:; key_result=false; entry_uuid=1ed154bb-b490-4274-b434-4ee8c4c54b6d
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 1000 mg/kg bw/day - - - one-generation reproductive toxicity dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=f51493e9-6ba0-4b36-a6b8-32d91346f9e2_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=f51493e9-6ba0-4b36-a6b8-32d91346f9e2/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=ToxicityReproduction; basis=other:; key_result=false; entry_uuid=071cae9d-e6cb-4576-99c1-2c8faa27f85f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 100 mg/kg bw/day rat oral: feed - carcinogenicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=93782e77-b0dc-42ed-bf6a-d03360413876_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=93782e77-b0dc-42ed-bf6a-d03360413876/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=ff31afae-d5cc-4f91-b563-f5650e41eccf
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 60 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=a2f9ebf3-38fe-453c-8b38-fd89d1c2bc43_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=a2f9ebf3-38fe-453c-8b38-fd89d1c2bc43/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2016; basis=body weight and weight gain; key_result=true; entry_uuid=6777e7bf-f8bd-4a24-ab23-ec76eb34a24f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 200 mg/kg bw/day - - - one-generation reproductive toxicity dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=f51493e9-6ba0-4b36-a6b8-32d91346f9e2_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=f51493e9-6ba0-4b36-a6b8-32d91346f9e2/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=ToxicityReproduction; basis=other:; key_result=false; entry_uuid=1ed154bb-b490-4274-b434-4ee8c4c54b6d
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 1000 mg/kg bw/day - - - one-generation reproductive toxicity dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=f51493e9-6ba0-4b36-a6b8-32d91346f9e2_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=f51493e9-6ba0-4b36-a6b8-32d91346f9e2/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=ToxicityReproduction; basis=other:; key_result=false; entry_uuid=071cae9d-e6cb-4576-99c1-2c8faa27f85f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 100 mg/kg bw/day rat oral: feed - carcinogenicity: oral dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=93782e77-b0dc-42ed-bf6a-d03360413876_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=93782e77-b0dc-42ed-bf6a-d03360413876/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=Carcinogenicity; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=ff31afae-d5cc-4f91-b563-f5650e41eccf
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 60 mg/kg bw/day rabbit oral: gavage - developmental toxicity dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=a2f9ebf3-38fe-453c-8b38-fd89d1c2bc43_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=a2f9ebf3-38fe-453c-8b38-fd89d1c2bc43/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2016; basis=body weight and weight gain; key_result=true; entry_uuid=6777e7bf-f8bd-4a24-ab23-ec76eb34a24f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 200 mg/kg bw/day - - - one-generation reproductive toxicity dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=f51493e9-6ba0-4b36-a6b8-32d91346f9e2_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=f51493e9-6ba0-4b36-a6b8-32d91346f9e2/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=ToxicityReproduction; basis=other:; key_result=false; entry_uuid=1ed154bb-b490-4274-b434-4ee8c4c54b6d
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 1000 mg/kg bw/day - - - one-generation reproductive toxicity dossier=c0b5d749-77b0-48d5-8074-0423482b10ef.i6z; document=f51493e9-6ba0-4b36-a6b8-32d91346f9e2_c0b5d749-77b0-48d5-8074-0423482b10ef.i6d; document_key=f51493e9-6ba0-4b36-a6b8-32d91346f9e2/c0b5d749-77b0-48d5-8074-0423482b10ef; document_subtype=ToxicityReproduction; basis=other:; key_result=false; entry_uuid=071cae9d-e6cb-4576-99c1-2c8faa27f85f
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOEL =50 mg/kg bw/day Rat oral: feed 84 days subchronic EFSA FEEDAP - 2016 - OutputID 2864 - no adverse effect observed - Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4559
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOEL =50 mg/kg bw/day Rat oral: feed 84 days subchronic EFSA FEEDAP - 2016 - OutputID 2864 - no adverse effect observed - Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4559
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=6630; RecordID=ARPathway2016_466; DatasetName=ARPathway2016; DTXSID=DTXSID3041790; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041790
NTP_ICE_skin_sensitization 11 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 3.65 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2965; Record_ID=skin_sensitization_invivo_782; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041790; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=3.65; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041790
NTP_ICE_skin_sensitization Concentration, one positive response 1 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2962; Record_ID=skin_sensitization_invivo_782; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041790; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=1; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041790
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2944; Record_ID=skin_sensitization_invivo_779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041790; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90208-4|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041790
NTP_ICE_skin_sensitization Incidence of positive responses 13.7 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2958; Record_ID=skin_sensitization_invivo_782; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041790; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=13.7; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041790
NTP_ICE_skin_sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2942; Record_ID=skin_sensitization_invivo_779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041790; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90208-4|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041790
NTP_ICE_skin_sensitization Induction dose per skin area 7087 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2949; Record_ID=skin_sensitization_invivo_780; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041790; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=7087; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041790
NTP_ICE_skin_sensitization Induction dose per skin area 6299 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2956; Record_ID=skin_sensitization_invivo_782; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041790; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=6299; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041790
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 2299 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2967; Record_ID=skin_sensitization_invivo_782; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041790; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=2299; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041790
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 629.9 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2963; Record_ID=skin_sensitization_invivo_782; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041790; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=629.9; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041790
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2947; Record_ID=skin_sensitization_invivo_779; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041790; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90208-4|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041790
NTP_ICE_skin_sensitization Relative reliability score 2 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=2955; Record_ID=skin_sensitization_invivo_780; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3041790; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1980; 7441083; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041790
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOEL =50 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4559.; TITLE=Safety and efficacy of non-conjugated and accumulated unsaturated straight-chain and branched-chain, aliphatic primary alcohols, aldehydes, acids, acetals and esters belonging to chemical group 4 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4559; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15621849:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_def982d2c2645763b24b37b66bb5cb99
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =9 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630738:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1623909441be320dfb5af4858206cd0a
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier QB99VZZ7GZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"QB99VZZ7GZ"}
openFDA substances FDA UNII substance identifier QB99VZZ7GZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"QB99VZZ7GZ"}
openFDA substances FDA UNII substance identifier QB99VZZ7GZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"QB99VZZ7GZ"}
openFDA substances FDA UNII substance identifier QB99VZZ7GZ UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"QB99VZZ7GZ"}