NOAEL Studies Cosmetic Ingredient

Citric Acid Hydrate NOAEL Studies

INCI: CITRIC ACID

CAS: 5949-29-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB LOAEL 300 mg/kg bw/day rat oral 4 week Short Term Toxicity SCCS
COSMOS_DB LOAEL 75 mg/kg bw/day rat oral 28 day Short Term Toxicity SCCS; CIT F-Evreux, Laboratory Study number 31589 TSR (27 December 2006). 4-week toxicity study by oral route (gavage) in rats followed by a 2-week treatment-freeperiod with FAT 81’034/D
COSMOS_DB NOAEL 272 mg/kg bw/day hamster oral 5 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 800 mg/kg bw/day rat oral NA Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2000 mg/kg bw/day rat oral 728 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 241 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 295 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 200 mg/kg bw/day rat oral 9 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 4670 mg/kg bw/day rat oral 42 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 600 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1380 mg/kg bw/day dog oral 112 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 425 mg/kg bw/day rabbit oral 13 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 75 mg/kg bw/day rat oral 4 week Short Term Toxicity SCCS
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 2968PHW8QP UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H8O7.H2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2968PHW8QP"}
openFDA substances FDA UNII substance identifier 2968PHW8QP UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H8O7.H2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2968PHW8QP"}
openFDA substances FDA UNII substance identifier 2968PHW8QP UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H8O7.H2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2968PHW8QP"}
openFDA substances FDA UNII substance identifier 2968PHW8QP UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H8O7.H2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2968PHW8QP"}