NOAEL Studies Cosmetic Ingredient

Cinnamyl Acetate NOAEL Studies

INCI: CINNAMYL ACETATE

CAS: 103-54-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =275 mg/kg bw/day Rat oral: feed 98 days subchronic EFSA FEEDAP - 2017 - OutputID 2920 - clinical chemistry - systemic - Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species - doi:10.2903/j.efsa.2017.4672
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =275 mg/kg bw/day Rat oral: feed 98 days subchronic EFSA FEEDAP - 2017 - OutputID 2920 - clinical chemistry - systemic - Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species - doi:10.2903/j.efsa.2017.4672
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =3300 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_344; row=4806; data_type=In Vivo; mixture=Chemical; chemical_name=3-Phenylprop-2-en-1-yl acetate; preferred_name=3-Phenyl-2-propen-1-yl acetate; dtxsid=DTXSID2044765; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2044765; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2180; Record_ID=skin_sensitization_invivo_629; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2044765; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|RIFM 1972; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1973; Not available; 10.1016/0015-6264(73)90252-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2044765
NTP_ICE_skin_sensitization Induction dose per skin area 3240 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2178; Record_ID=skin_sensitization_invivo_629; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2044765; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=3240; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|RIFM 1972; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1973; Not available; 10.1016/0015-6264(73)90252-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2044765
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2185; Record_ID=skin_sensitization_invivo_629; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2044765; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|RIFM 1972; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1973; Not available; 10.1016/0015-6264(73)90252-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2044765
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =275 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=EFSA FEEDAP (2017). Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species. doi:10.2903/j.efsa.2017.4672.; TITLE=Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2017.4672; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA:15621615:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a593bd18f58b252c972f9a710b5ae5c4
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =2.35 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630735:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7e9a3846c5caab2138cf9a3d2f086bbb
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier LFJ36XSV8K UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LFJ36XSV8K"}
openFDA substances FDA UNII substance identifier LFJ36XSV8K UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LFJ36XSV8K"}
openFDA substances FDA UNII substance identifier LFJ36XSV8K UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LFJ36XSV8K"}
openFDA substances FDA UNII substance identifier LFJ36XSV8K UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LFJ36XSV8K"}