NOAEL Studies Cosmetic Ingredient

Cineole (Eucalyptol) NOAEL Studies

INCI: EUCALYPTOL (CINEOLE / 1,8-CINEOLE ARE COMMON SYNONYMS)

CAS: 470-82-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 200 mg/kg bw/day rat oral 3 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =1000 mg/kg bw Rat oral: gavage 35 days subchronic EFSA - 2020 - OutputID 3638 - organ weights - systemic - Safety and efficacy of essential oil, oleoresin and tincture from Zingiber officinale Roscoe when used as sensory additives in feed for all animal species - doi:10.2903/j.efsa.2020.6147
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =562.5 mg/kg bw/day Mouse oral: capsule 28 days short-term toxicity EFSA FEEDAP - 2012 - OutputID 2156 - other - hepatotoxicity - Scientific Opinion on the safety and efficacy of aliphatic and alicyclic ethers (chemical group 16) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2967
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =562.5 mg/kg bw/day Mouse oral: capsule 28 days short-term toxicity EFSA FEEDAP - 2012 - OutputID 2156 - other - hepatotoxicity - Scientific Opinion on the safety and efficacy of aliphatic and alicyclic ethers (chemical group 16) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2967
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =1000 mg/kg bw Rat oral: gavage 35 days subchronic EFSA - 2020 - OutputID 3638 - organ weights - systemic - Safety and efficacy of essential oil, oleoresin and tincture from Zingiber officinale Roscoe when used as sensory additives in feed for all animal species - doi:10.2903/j.efsa.2020.6147
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=882; RecordID=ARPathway2016_1224; DatasetName=ARPathway2016; DTXSID=DTXSID4020616; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020616; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020616
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7495; Record_ID=skin_sensitization_invivo_1698; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=16.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4020616; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90094-2|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020616; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020616
NTP_ICE_skin_sensitization Induction dose per skin area 10370 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7448; Record_ID=skin_sensitization_invivo_1698; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=16.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4020616; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=10370; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90094-2|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020616; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020616
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=7498; Record_ID=skin_sensitization_invivo_1698; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=16.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4020616; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90094-2|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4020616; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4020616
ToxValDB_ECHA_IUCLID 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =250 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d17de4b0a7c65d22ed6f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/9/3?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15822236:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e4a19aed6ec8c35bd96e27686a26e160
ToxValDB_ECHA_IUCLID LOAEL =100 mg/kg bw/day Rat oral subchronic; 50 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cba8e4b0a7c65d227045; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID:15838757:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6a98f46e7c9ce8b71978ba5cb4f7517f
ToxValDB_ECHA_IUCLID NOAEL =64.15 mg/kg bw/day Mouse oral short-term; 30 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9f5e4b0a7c65d21f8e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15829976:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_234bdd1a290db11e357d6611546e5d52
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =562.5 mg/kg bw/day Mouse oral short-term; 28 days short-term LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of aliphatic and alicyclic ethers (chemical group 16) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2967.; TITLE=Scientific Opinion on the safety and efficacy of aliphatic and alicyclic ethers (chemical group 16) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2967; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=other; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=EFSA:15620808:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_25ea10b789fc1d8b21c503d4cd45895b
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =7.05 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630732:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2b02b952264b36a4a773f0641732995f
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier RV6J6604TK UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RV6J6604TK"}
openFDA substances FDA UNII substance identifier RV6J6604TK UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RV6J6604TK"}
openFDA substances FDA UNII substance identifier RV6J6604TK UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RV6J6604TK"}
openFDA substances FDA UNII substance identifier RV6J6604TK UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RV6J6604TK"}