Is CI 73000 safe in cosmetics?
CI 73000 has a safety rating of "MODERATE" in our database. EU status: restricted. US status: restricted.
Moderate
Cosmetic Ingredient
CI 73000
Also known as: C.I Vat Blue 1, C.I. 73000, 2-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,2- dihydro-3H-indol-3-one, 2-(3-Oxo-1,3-dihydro-2H-indol-2-ylidene)-1,2-dihydro-3H-indol-3-one, 11669 Blue (+15 more)
CI 73000 (CAS 482-89-3) is a cosmetic cosmetic ingredient functioning as Colorant. NOAEL 0.87 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 482-89-3 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(3-hydroxy-1H-indol-2-yl)indol-3-one
InChIKey
QQILFGKZUJYXGS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
FDA permanently listed as D&C Blue No. 6 (21 CFR 73.3119, 74.1109) for use in surgical sutures only (collagen, polypropylene, polydioxanone sutures) with strict concentration limits (0.2–0.5%); not approved for general cosmetic use; EU-regulated under Annex IV
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 73000.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for CI 73000 across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Blue
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (IV - Colorants)
BRIN Brazil/India Cosmetics
India: Permitted Colorant
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | All products |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
colorant
{"Common_Name": "D&C Blue No. 4", "Chemical_Name": "Alphazurine FG", "CAS_Number": "6408-78-2", "Colorant_Type": "Synthetic Dye", "Approved_Uses": "All cosmetics", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved 21 CFR 74.104", "Notes": "Indophenol dye"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Surface modifier
Expert Verdict
Expert safety assessment and concern-level summary for CI 73000.
Regulatory Flags
not-for-general-cosmetics
fda-device-sutures-only
natural-origin
vat-dye
regulatory-verification-needed
Known Synonyms
C.I Vat Blue 1
C.I. 73000
2-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,2- dihydro-3H-indol-3-one
2-(3-Oxo-1,3-dihydro-2H-indol-2-ylidene)-1,2-dihydro-3H-indol-3-one
11669 Blue
2,2'-Bis(2,3-dihydro-3-oxoindolylidene)
Bezema Indigo AXX-FL
C.I. Natural Blue 1
D+C Blue No. 6
Dystar Indigo Gr
Indigo Powder W
Indigotin (natural)
Japan Blue 201
Natural Blue 1
Reduced Dark Blue VB
Vat Dark Blue VB
Indigotine
C Blue 22
Vat Blue 1
3H-Indol-3-one, 2-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro-(Indigo Blue)
Chemical Function
Dye
Surface modifier
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
Medical/dental
Europe; Other direct contact consumer goods; residue
Environmental Research
Australian Status
AICIS status: listed
Frequently Asked Questions
Is CI 73000 allowed in the EU?
CI 73000 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 73000 do in cosmetics?
CI 73000 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 482-89-3.
Is CI 73000 used outside cosmetics?
CI 73000 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 73000 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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