Is CI 44090 safe in cosmetics?
CI 44090 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: prohibited. 1 toxicological study endpoint(s) are available in our database.
CI 44090
CI 44090 (CAS 3087-16-9) is a cosmetic cosmetic ingredient functioning as Colorant. Reported NOAEL =1000 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 3087-16-9 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
sodium 4-[[4-(dimethylamino)phenyl]-(4-dimethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]-3-hydroxynaphthalene-2,7-disulfonate
InChIKey
WDPIZEKLJKBSOZ-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Not an approved FDA D&C or FD&C color additive for cosmetics in the US. Green S is banned as a food/cosmetic colorant by the FDA.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 44090.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for CI 44090. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Green
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (IV - Colorants)
BRIN Brazil/India Cosmetics
India: Permitted Colorant
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Evaluation
GREEN S | 1974 | NO ADI ALLOCATED | Previous temporary ADI withdrawn. | NMRS 54/TRS 557-JECFA 18/17 | FAS 6/NMRS 54A-JECFA 18/89
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for CI 44090.
Regulatory Flags
not-fda-approved
eu-food-colorant-e142
synthetic-dye
triphenylmethane-dye
purity-criteria-required
jecfa_concern
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to CI 44090 by CAS number or substance name.
Studies
1
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Chemical Function
Dye
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2028349
Frequently Asked Questions
Is CI 44090 allowed in the EU?
CI 44090 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 44090 do in cosmetics?
CI 44090 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 3087-16-9.
What is the NOAEL for CI 44090?
The NOAEL (No Observed Adverse Effect Level) for CI 44090 is =1000 mg/kg bw/day based on a developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is CI 44090 used outside cosmetics?
CI 44090 also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 44090 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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