Is CI 44045 safe in cosmetics?
CI 44045 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: prohibited.
Moderate
Cosmetic Ingredient
CI 44045
Also known as: Methanaminium, N-[4-[[4-(dimethylamino)phenyl][4-(phenylamino)-1-naphthalenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chloride, Methanaminium, N-[4-[[4-(dimethylamino)phenyl][4-(phenylamino)-1-naphthalenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chloride (1:1), (4-((4-Anilino-1-naphthyl)(4-(dimethylamino)phenyl)methylene)cyclohexa-2,5-dien-1-ylidene)dimethylammonium chloride, N-(4-((4-(Dimethylamino)phenyl)(4-(phenylamino)-1-naphthalenyl)methylene)-2,5- cyclohexadien-1-ylidene)-N-methylmethanaminium, chloride, ADC Victoria Blue B (+15 more)
CI 44045 (CAS 2580-56-5) is a cosmetic cosmetic ingredient functioning as Colorant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 2580-56-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
CI 44045 is classified GHS Danger (H302, H317, H318, H319, H400, H410, H301, H351) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Colorant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
[4-[bis[4-(dimethylamino)phenyl]methylidene]naphthalen-1-ylidene]-phenylazanium chloride
InChIKey
LLWJPGAKXJBKKA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Not listed as a permitted FDA D&C or FD&C color additive; not approved for cosmetic use in the US.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 44045.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
Yes (since 18-Jun-2012)
Hazard classification: Restricted (Annex XVII)
SVHC reason: Carcinogenic (Article 57a)
Substance of Very High Concern (SVHC)
Included: 18-Jun-2012
Carcinogenic (Article 57a)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1340
(EC) 2013/344
Annex IV — Permitted Colorants
Product type: Blue
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1340
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
India: Permitted Colorant
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (3)
EU Banned in Cosmetics
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for CI 44045.
Regulatory Flags
restricted-application-site
not-for-mucous-membranes
not-fda-approved
synthetic-dye
triarylmethane-dye
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
Methanaminium, N-[4-[[4-(dimethylamino)phenyl][4-(phenylamino)-1-naphthalenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chloride
Methanaminium, N-[4-[[4-(dimethylamino)phenyl][4-(phenylamino)-1-naphthalenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chloride (1:1)
(4-((4-Anilino-1-naphthyl)(4-(dimethylamino)phenyl)methylene)cyclohexa-2,5-dien-1-ylidene)dimethylammonium chloride
N-(4-((4-(Dimethylamino)phenyl)(4-(phenylamino)-1-naphthalenyl)methylene)-2,5- cyclohexadien-1-ylidene)-N-methylmethanaminium, chloride
ADC Victoria Blue B
Aizen Victoria Blue B Base
Aizen Victoria Blue BH
Calcozine Blue B
EINECS 219-943-6
Hecto Blue B
Hekto Blue B
Hidaco Victoria Blue B
Hidaco Victoria Blue B Base
Mitsui Victoria Blue B
NSC 11245
Symulex Blue BOF
Tertrophene Blue
Tungstate Blue Toner BT-311
Victoria Blue B
Victoria Blue BA
Chemical Function
Dye
Regulatory Lists
Europe; Personal care
banned; Europe; Personal care
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is CI 44045 allowed in the EU?
CI 44045 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 44045 do in cosmetics?
CI 44045 functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 2580-56-5.
Is CI 44045 used outside cosmetics?
CI 44045 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does CI 44045 have different safety status in cosmetics vs industrial chemicals?
CI 44045 is classified GHS Danger (H302, H317, H318, H319, H400, H410, H301, H351) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check CI 44045 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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