NOAEL Studies Cosmetic Ingredient

CI 18050 NOAEL Studies

CAS: 3734-67-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=6024; RecordID=ARPathway2016_1176; DatasetName=ARPathway2016; DTXSID=DTXSID9044663; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9044663
ToxValDB_ECHA_IUCLID 11 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =20 mg/kg bw/day Mouse oral subchronic; 3 months subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7e01; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17290/7/6/2?documentUUID=6a32a780-0425-462e-8647-5b0fab27a772; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15848019:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a891985a2f5179bf9b7a86ad65d4043e
ToxValDB_ECHA_IUCLID LOAEL =50 mg/kg bw/day Rat oral subchronic; 2 months subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7e05; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17290/7/6/2?documentUUID=6a32a780-0425-462e-8647-5b0fab27a772; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15848193:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9a4fc9ec755d7dab18f81acccdbd14f8
ToxValDB_ECHA_IUCLID NOAEL =10 mg/kg bw/day Rat oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac26e4b0a7c65d1bd9a2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17290/7/9/3?documentUUID=6a32a780-0425-462e-8647-5b0fab27a772; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822341_15822413_15823340:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_beacba568bfda5b15e5692351c813d29
ToxValDB_ECHA_IUCLID NOAEL =11.4 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8f6e4b0a7c65d21ae6f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17290/7/9/2?documentUUID=6a32a780-0425-462e-8647-5b0fab27a772; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15857774:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1e5c00282dde3f44073e3cfba77a2975
ToxValDB_ECHA_IUCLID NOAEL =25 mg/kg bw/day Rat oral - developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac26e4b0a7c65d1bd99c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17290/7/9/3?documentUUID=6a32a780-0425-462e-8647-5b0fab27a772; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15824800:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c14d5fc5ad108c6de9fa4bbb2466c6bd
ToxValDB_ECHA_IUCLID NOAEL =100 mg/kg bw/day Rat oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1d0e4b0a7c65d23057f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17290/7/9/3?documentUUID=6a32a780-0425-462e-8647-5b0fab27a772; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822341_15822413_15823340:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_66d34152fd87161e6f21d0dfa0131f2e
ToxValDB_ECHA_IUCLID NOAEL =129 mg/kg bw/day Rat oral - developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac26e4b0a7c65d1bd9a4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17290/7/9/3?documentUUID=6a32a780-0425-462e-8647-5b0fab27a772; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15823285:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ca256911f5cd09e780a9c7d34211a566
ToxValDB_ECHA_IUCLID NOAEL =937.5 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8f6e4b0a7c65d21ae47; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17290/7/9/2?documentUUID=6a32a780-0425-462e-8647-5b0fab27a772; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857117_15862315:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d3335843a5025b9715872747a21f73b5
ToxValDB_ECHA_IUCLID NOAEL =1500 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b8261; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17290/7/9/2?documentUUID=6a32a780-0425-462e-8647-5b0fab27a772; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15861320:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b0f34aaa2e71a2e85785fadc7460cf7f
ToxValDB_ECHA_IUCLID NOAEL =2000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b8265; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17290/7/9/2?documentUUID=6a32a780-0425-462e-8647-5b0fab27a772; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857673_15857762_15860758:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b82f2ebe996fb13a6e835b939cbefaa4
ToxValDB_ECHA_IUCLID NOAEL =3000 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b8258; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17290/7/9/2?documentUUID=6a32a780-0425-462e-8647-5b0fab27a772; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857117_15862315:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_26e9deb69e828139f63beca6df4e8b26
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA BMDL (10) ~29 mg/kg bw/day Rat oral chronic; 104 weeks chronic LONG_REF=EFSA AFC (2007). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on the food colour Red 2G (E128) based on a request from the Commission related to the re-evaluation of all permitted food additives. doi:10.2903/j.efsa.2007.515.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on the food colour Red 2G (E128) based on a request from the Commission related to the re-evaluation of all permitted food additives; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2007.515; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; STUDY_GROUP=EFSA:15614214:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_90e8c6888fa38845505bc0b372540a64
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=0.1 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afa11e4b0d99f5a878ecf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/539; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=WHO JECFA ADI:15715272:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3766ea6f74df197b8313782700cb89eb
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3365R6427R UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H13N3O8S2.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3365R6427R"}
openFDA substances FDA UNII substance identifier 3365R6427R UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H13N3O8S2.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3365R6427R"}
openFDA substances FDA UNII substance identifier 3365R6427R UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H13N3O8S2.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3365R6427R"}
openFDA substances FDA UNII substance identifier 3365R6427R UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H13N3O8S2.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3365R6427R"}