Is CI 12490 (Pigment Red 5 / Permanent Carmine FB) safe in cosmetics?
CI 12490 (Pigment Red 5 / Permanent Carmine FB) has a safety rating of "MODERATE" in our database. EU status: restricted. US status: prohibited.
Moderate
Cosmetic Ingredient
CI 12490 (Pigment Red 5 / Permanent Carmine FB)
Also known as: 2-Naphthalenecarboxamide, N-(5-chloro-2,4-dimethoxyphenyl)-4-[2-[5-[(diethylamino)sulfonyl]-2-methoxyphenyl]diazenyl]-3-hydroxy-, 2-Naphthalenecarboxamide, N-(5-chloro-2,4-dimethoxyphenyl)-4-((5-((diethylamino)sulfonyl)-2-methoxyphenyl)azo)-3-hydroxy-, N-(5-Chloro-2,4-dimethoxyphenyl)-4-((5-((diethylamino)sulphonyl)-2-methoxyphenyl)azo)-3-hydroxynaphthalene-2-carboxamide, EINECS 229-107-2, UNII-91OZU993LX
INCI: CI 12490
CI 12490 (Pigment Red 5 / Permanent Carmine FB) (CAS 6410-41-9) is a cosmetic cosmetic ingredient functioning as Colorant. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 6410-41-9 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
N-(5-chloro-2,4-dimethoxyphenyl)-4-[[5-(diethylsulfamoyl)-2-methoxyphenyl]diazenyl]-3-hydroxynaphthalene-2-carboxamide
InChIKey
LMULDSDQRQVZMW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
prohibited
US Notes
Not listed on FDA-approved color additives list (21 CFR Parts 73/74/82). Identified in FDA Import Alert 53-06 as no certifiable equivalent — non-permitted. Use in US cosmetics constitutes adulteration under the FD&C Act.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 12490 (Pigment Red 5 / Permanent Carmine FB).
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1347
(EC) 2013/344
Annex IV — Permitted Colorants
Product type: Red
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1347
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
India: Permitted Colorant
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | banned | - | all cosmetics |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
colorant
{"Common_Name": "D&C Orange No. 5", "Chemical_Name": "Dibromodinitrofluorescein disodium", "CAS_Number": "596-03-2", "Colorant_Type": "Synthetic Dye", "Approved_Uses": "Lipstick, external cosmetics", "Max_Concentration_%": "No limit", "EU_Status": "Not approved", "US_FDA_Status": "Approved 21 CFR 74.255", "Notes": "US only"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Fragrance
Pigment
Regulatory List Membership (4)
EU Banned in Cosmetics
EU Regulated in Personal Care
IFRA Fragrance Transparency List
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for CI 12490 (Pigment Red 5 / Permanent Carmine FB).
Regulatory Flags
eu-annex-iv
eu-annex-ii-hair-dye-prohibited
not-fda-approved
fda-import-alert-53-06
azo-dye
aromatic-amine-precursor
hair-dye-prohibited-eu
mucous-membrane-concern
eu_banned_cosmetics
ifra_fragrance
eu_cosing_listed
Known Synonyms
2-Naphthalenecarboxamide, N-(5-chloro-2,4-dimethoxyphenyl)-4-[2-[5-[(diethylamino)sulfonyl]-2-methoxyphenyl]diazenyl]-3-hydroxy-
2-Naphthalenecarboxamide, N-(5-chloro-2,4-dimethoxyphenyl)-4-((5-((diethylamino)sulfonyl)-2-methoxyphenyl)azo)-3-hydroxy-
N-(5-Chloro-2,4-dimethoxyphenyl)-4-((5-((diethylamino)sulphonyl)-2-methoxyphenyl)azo)-3-hydroxynaphthalene-2-carboxamide
EINECS 229-107-2
UNII-91OZU993LX
Chemical Function
Dye
Fragrance
Pigment
Regulatory Lists
IFRA Transparency
inert_ingredient; non_food_use; Pesticides
Europe; Personal care
banned; Europe; Personal care
Arts and crafts/Office supplies - body paint - tattoo ink; Europe
Arts and crafts/Office supplies - body paint - tattoo ink; Europe
Arts and crafts/Office supplies - body paint - tattoo ink; Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is CI 12490 (Pigment Red 5 / Permanent Carmine FB) allowed in the EU?
CI 12490 (Pigment Red 5 / Permanent Carmine FB) EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 12490 (Pigment Red 5 / Permanent Carmine FB) do in cosmetics?
CI 12490 (Pigment Red 5 / Permanent Carmine FB) functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 6410-41-9.
Is CI 12490 (Pigment Red 5 / Permanent Carmine FB) used outside cosmetics?
CI 12490 (Pigment Red 5 / Permanent Carmine FB) also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 12490 (Pigment Red 5 / Permanent Carmine FB) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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