Is Cholesteryl Oleate safe in cosmetics?
Cholesteryl Oleate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Cholesteryl Oleate
Also known as: Cholest-5-en-3-ol (3β)-, 3-[(9Z)-9-octadecenoate], Cholest-5-en-3-ol (3β)-, 9-octadecenoate, (Z)-, Cholesterol, oleate, Cholest-5-en-3-beta-yl oleate, Cholest-5-en-3-ol (3β)-, (9Z)-9-octadecenoate (+12 more)
INCI: CHOLESTERYL OLEATE
Cholesteryl Oleate (CAS 303-43-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent (emollient); lipid-identical component found in skin. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 303-43-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent (emollient); lipid-identical component found in skin surface lipids
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] (Z)-octadec-9-enoate
InChIKey
RJECHNNFRHZQKU-RMUVNZEASA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA permitted for cosmetic use; no restrictions. Not CIR-reviewed as standalone, but parent cholesterol assessed safe as used (CIR 1986, reaffirmed 2004, 2024 re-review)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cholesteryl Oleate.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Softener and conditioner
Regulatory List Membership (1)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Cholesteryl Oleate.
Known Synonyms
Cholest-5-en-3-ol (3β)-, 3-[(9Z)-9-octadecenoate]
Cholest-5-en-3-ol (3β)-, 9-octadecenoate, (Z)-
Cholesterol, oleate
Cholest-5-en-3-beta-yl oleate
Cholest-5-en-3-ol (3β)-, (9Z)-9-octadecenoate
Oleic acid, cholesteryl ester
Cholesteryl cis-9-octadecenoate
Oleoylcholesterol
Cholesterol 3β-oleate
Cholesteryl oleic ester
Cholest-5-en-3-β-yl oleate
NSC 18186
Yofco LC-CO-D
CE(18:1)
EC No.: 206-142-1
206-142-1
EINECS 206-142-1
Chemical Function
Softener and conditioner
Fragrance
Regulatory Lists
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CHOLESTERYL OLEATE
ChEMBL ID
CHEMBL1097567
Frequently Asked Questions
Is Cholesteryl Oleate allowed in the EU?
Cholesteryl Oleate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cholesteryl Oleate do in cosmetics?
Cholesteryl Oleate functions as: Skin conditioning agent (emollient); lipid-identical component found in skin surface lipids. It is classified as a cosmetic ingredient in our database. CAS number: 303-43-5.
Is Cholesteryl Oleate used outside cosmetics?
Cholesteryl Oleate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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