Is Cholesteryl Acetate safe in cosmetics?
Cholesteryl Acetate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Cholesteryl Acetate
INCI: CHOLESTERYL ACETATE
Cholesteryl Acetate (CAS 604-35-3) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent (emollient, cholesterol ester for barrier repair). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 604-35-3 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent (emollient, cholesterol ester for barrier repair)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
InChIKey
XUGISPSHIFXEHZ-VEVYEIKRSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR reviewed cholesterol and derivatives — concluded safe as used (1986, reaffirmed 2004 and 2024)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cholesteryl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Viscosity modifier
Expert Verdict
Expert safety assessment and concern-level summary for Cholesteryl Acetate.
Chemical Function
Softener and conditioner
Viscosity modifier
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3138728
Frequently Asked Questions
Is Cholesteryl Acetate allowed in the EU?
Cholesteryl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cholesteryl Acetate do in cosmetics?
Cholesteryl Acetate functions as: Skin conditioning agent (emollient, cholesterol ester for barrier repair). It is classified as a cosmetic ingredient in our database. CAS number: 604-35-3.
Is Cholesteryl Acetate used outside cosmetics?
Cholesteryl Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cholesteryl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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