Is CHLORHEXIDINE DIACETATE safe in cosmetics?
CHLORHEXIDINE DIACETATE has a safety rating of "MODERATE" in our database. EU status: restricted. US status: restricted.
Moderate
Cosmetic Ingredient
CHLORHEXIDINE DIACETATE
Also known as: Chlorohexidine diacetate, Tetraazatetradecanediimidamide, N,N′′-bis(4-chlorophenyl)-3,12-diimino-, diacetate, Biguanide, 1,1′-hexamethylenebis[5-(p-chlorophenyl)-, diacetate 2,4,11,13-, 2,4,11,13-Tetraazatetradecanediimidamide, N,N′′-bis(4-chlorophenyl)-3,12-diimino-, acetate (1:2), 10,040 Diacetate (+15 more)
CHLORHEXIDINE DIACETATE (CAS 56-95-1) is a cosmetic cosmetic ingredient functioning as Antimicrobial, Oral Care, Preservative. EU Regulation 1223/2009 status: restricted, max V/42. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 56-95-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
CHLORHEXIDINE DIACETATE is classified GHS Danger (H317, H318, H334, H301, H302, H319, H400, H410) in the chemicals database but is restricted in EU cosmetics at max V/42.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antimicrobial, Oral Care, Preservative
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
acetic acid;(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine
InChIKey
WDRFFJWBUDTUCA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
V/42
US US Status
restricted
US Notes
CIR: SQ - IJT 30(Suppl. 2):73-127, 2011
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CHLORHEXIDINE DIACETATE.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LEL | =15.63 mg/kg-day | Rat | oral | short-term (developmental) | ToxRefDB |
| LEL | >62.5 mg/kg-day | Rat | oral | short-term (developmental) | ToxRefDB |
| LOAEL | =31.25 mg/kg-day | Rat | oral | short-term (developmental) | ToxRefDB |
| LOAEL | >62.5 mg/kg-day | Rat | oral | short-term (developmental) | ToxRefDB |
| NEL | >=62.5 mg/kg-day | Rat | oral | short-term (developmental) | ToxRefDB |
| NOAEL | =15.63 mg/kg-day | Rat | oral | short-term (developmental) | ToxRefDB |
| NOAEL | >=62.5 mg/kg-day | Rat | oral | short-term (developmental) | ToxRefDB |
| LEL | =250 mg/kg-day | Rat | oral | short-term (developmental) | ToxRefDB |
| LEL | >2000 mg/kg-day | Rat | oral | short-term (developmental) | ToxRefDB |
| LEL | =250 mg/kg-day | Rabbit | dermal | subchronic | ToxRefDB |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | permitted_preservative | 0.3 | 0.3% as chlorhexidine |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
preservative
{"preservative_class": "Biguanide", "antimicrobial_spectrum_bacteria_gp": "Excellent", "antimicrobial_spectrum_bacteria_gn": "Good", "antimicrobial_spectrum_yeast": "Yes", "antimicrobial_spectrum_mold": "Moderate", "mic_staph_aureus_ppm": "32", "mic_e_coli_ppm": "85", "mic_pseudomonas_ppm": "105", "mic_candida_albicans_ppm": "160", "mic_aspergillus_niger_ppm": "420", "challenge_test_pass_concentra…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Preservative
Expert Verdict
Expert safety assessment and concern-level summary for CHLORHEXIDINE DIACETATE.
Regulatory Flags
cosing-sourced
eu-restricted
preservative
needs-enrichment
Known Synonyms
Chlorohexidine diacetate
Tetraazatetradecanediimidamide, N,N′′-bis(4-chlorophenyl)-3,12-diimino-, diacetate
Biguanide, 1,1′-hexamethylenebis[5-(p-chlorophenyl)-, diacetate 2,4,11,13-
2,4,11,13-Tetraazatetradecanediimidamide, N,N′′-bis(4-chlorophenyl)-3,12-diimino-, acetate (1:2)
10,040 Diacetate
Bactigras
1,6-Bis(5-(p-chlorophenyl)biguandino)hexane diacetate
1,6-Bis(p-chlorophenylbiguanido)hexane diacetate
Bis(p-chlorophenyldiguanidohexane) diacetate
Caswell No. 481E
Chlorhexidine acetate
1,6-Di(4'-chlorophenyldiguanidino)hexane diacetate
EINECS 200-302-4
EPA Pesticide Chemical Code 045502
1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) diacetate
1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) diacetate
1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide)diacetate
Hibitane diacetate
NSC 526936
UNII-5908ZUF22Y
Chemical Function
Biocide
Preservative
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Australia
inert_ingredient; non_food_use; Pesticides
active_ingredient; Europe; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Frequently Asked Questions
Is CHLORHEXIDINE DIACETATE allowed in the EU?
CHLORHEXIDINE DIACETATE EU regulatory status: restricted. Maximum allowed concentration: V/42. This is based on EU Regulation 1223/2009 and its amendments.
What does CHLORHEXIDINE DIACETATE do in cosmetics?
CHLORHEXIDINE DIACETATE functions as: Antimicrobial, Oral Care, Preservative. It is classified as a cosmetic ingredient in our database. CAS number: 56-95-1.
Is CHLORHEXIDINE DIACETATE used outside cosmetics?
CHLORHEXIDINE DIACETATE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does CHLORHEXIDINE DIACETATE have different safety status in cosmetics vs industrial chemicals?
CHLORHEXIDINE DIACETATE is classified GHS Danger (H317, H318, H334, H301, H302, H319, H400, H410) in the chemicals database but is restricted in EU cosmetics at max V/42.
Compliance Tools
Check CHLORHEXIDINE DIACETATE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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