Is Chamazulene safe in cosmetics?
Chamazulene has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Chamazulene
Also known as: 4-05-00-01736, Azulene, 7-ethyl-1,4-dimethyl-, BRN 1306577, Camazulene, Chamazulen (+5 more)
INCI: CHAMAZULENE
Chamazulene (CAS 529-05-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 529-05-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
7-ethyl-1,4-dimethylazulene
InChIKey
GXGJIOMUZAGVEH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA has no specific restrictions. CIR has concluded data are insufficient for azulene, which is distinct from chamazulene and guaiazulene.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Chamazulene.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Chamazulene.
Known Synonyms
4-05-00-01736
Azulene, 7-ethyl-1,4-dimethyl-
BRN 1306577
Camazulene
Chamazulen
Dimethulen
Dimethulene
1,4-Dimethyl-7-ethylazulene
EINECS 208-449-6
UNII-Z439UH6E5F
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CHAMAZULENE
ChEMBL ID
CHEMBL495665
Frequently Asked Questions
Is Chamazulene allowed in the EU?
Chamazulene EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Chamazulene do in cosmetics?
Chamazulene functions as: Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 529-05-5.
Is Chamazulene used outside cosmetics?
Chamazulene also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Chamazulene compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Same category
Skin conditioning (skin brightening/l...
4-Amino-3-Hydroxybutyric Acid
Excellent
Same category
Skin Conditioning
Acetyl Glycyl Beta-Alanine
Excellent
Same category
Skin conditioning agent with melanin ...
Acetyl Tripeptide-1
Excellent
Same category
Skin Conditioning
Acetylneuraminic Acid
Excellent
Same category
Skin Conditioning, Skin Protecting
Acetylphytosphingosine
Excellent
Same category
Skin Conditioning, Hair Conditioning;...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
(SH-Pentapeptide-10 6-Aminocaprooyl SH-Pentapeptide-11) SP
Moderate
Similar safety
Skin/hair conditioning (peptide-based...
1,2,3,4,4a,5,6,7-Octahydro-2,5,5-Trimethyl-2-Naphthol
Moderate
Similar safety
Fragrance ingredient
1,2,3,4,4a,7,8,8a-Octahydro-2,4a,5,8a-Tetramethyl-Naphthyl Formate
Moderate
Similar safety
Fragrance ingredient
Genistein Glucoside
Moderate
Chemical family
Skin conditioning; antioxidant
Myricetin
Moderate
Chemical family
Antioxidant, skin conditioning
O-TOLUALDEHYDE
Good
Chemical family
Perfuming
Is Chamazulene in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Chamazulene in your formulation.