Is Cellulase safe in cosmetics?
Cellulase has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Cellulase
Also known as: EINECS 232-734-4
INCI: CELLULASE
Cellulase (CAS 9012-54-8) is a cosmetic cosmetic ingredient functioning as Skin conditioning (enzyme-based exfoliation). NOAEL 1013.3 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 9012-54-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Cellulase is classified GHS Danger (H334) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning (enzyme-based exfoliation)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6S)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
InChIKey
FYGDTMLNYKFZSV-CSHPIKHBSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS for food use; permitted in cosmetics under general provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cellulase.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Cellulase across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health Hazard
Hazard Class and Category
Resp. Sens. 1
Hazard Statements
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-stain agent
Chemical reaction regulator
Cleaning agent
Pharmaceutical
Stabilizing agent
Viscosity modifier
Regulatory List Membership (1)
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Cellulase.
Regulatory Flags
potential-allergen
epa_safer_alternative
Known Synonyms
EINECS 232-734-4
Chemical Function
Cleaning agent
Chemical reaction regulator
Viscosity modifier
Pharmaceutical
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
SCIL (9/2019)
fracking; water
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
fda_gras_enriched
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Cellulase from Penicillium funiculosum
FDA GRAS
FDA has no questions
GRN
584
For use as a processing aid in brewing, baking and potable alcohol production.
View full food safety profile →Frequently Asked Questions
Is Cellulase allowed in the EU?
Cellulase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cellulase do in cosmetics?
Cellulase functions as: Skin conditioning (enzyme-based exfoliation). It is classified as a cosmetic ingredient in our database. CAS number: 9012-54-8.
Is Cellulase used outside cosmetics?
Cellulase also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Cellulase have different safety status in cosmetics vs industrial chemicals?
Cellulase is classified GHS Danger (H334) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Cellulase compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Same category
Skin conditioning (skin brightening/l...
4-Amino-3-Hydroxybutyric Acid
Excellent
Same category
Skin Conditioning
Acetyl Glycyl Beta-Alanine
Excellent
Same category
Skin conditioning agent with melanin ...
Acetyl Tripeptide-1
Excellent
Same category
Skin Conditioning
Acetylneuraminic Acid
Excellent
Same category
Skin Conditioning, Skin Protecting
Acetylphytosphingosine
Excellent
Same category
Skin Conditioning, Hair Conditioning;...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
(SH-Pentapeptide-10 6-Aminocaprooyl SH-Pentapeptide-11) SP
Moderate
Similar safety
Skin/hair conditioning (peptide-based...
1,2,3,4,4a,5,6,7-Octahydro-2,5,5-Trimethyl-2-Naphthol
Moderate
Similar safety
Fragrance ingredient
1,2,3,4,4a,7,8,8a-Octahydro-2,4a,5,8a-Tetramethyl-Naphthyl Formate
Moderate
Similar safety
Fragrance ingredient
Agarose
Good
Chemical family
Film forming, viscosity controlling
Alpha-Glucan
Excellent
Chemical family
Skin Conditioning, Film Forming, Hume...
Chitosan
Good
Chemical family
Film Former, Antimicrobial, Antioxida...
Is Cellulase in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Cellulase in your formulation.