NOAEL Studies Emollient

Carnauba Wax NOAEL Studies

INCI: COPERNICIA CERIFERA (CARNAUBA) WAX

CAS: 8015-86-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS_DB 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 250 mg/kg bw/day dog oral 196 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 161 day Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 8800 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =250 mg/kg bw/day Dog oral: feed 196 days chronic/long term toxicity EFSA ANS - 2012 - OutputID 496 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive - doi:10.2903/j.efsa.2012.2880
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =250 mg/kg bw/day Dog oral: feed 196 days chronic/long term toxicity EFSA ANS - 2012 - OutputID 496 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive - doi:10.2903/j.efsa.2012.2880
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =670 mg/kg bw/day Rat oral: unspecified - reproduction toxicity EFSA ANS - 2012 - OutputID 496 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive - doi:10.2903/j.efsa.2012.2880
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =670 mg/kg bw/day Rat oral: unspecified - reproduction toxicity EFSA ANS - 2012 - OutputID 496 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive - doi:10.2903/j.efsa.2012.2880
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =1500 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA ANS - 2012 - OutputID 496 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive - doi:10.2903/j.efsa.2012.2880
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =1500 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA ANS - 2012 - OutputID 496 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive - doi:10.2903/j.efsa.2012.2880
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =8800 mg/kg bw/day Rat oral: feed 91 days subchronic EFSA ANS - 2012 - OutputID 496 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive - doi:10.2903/j.efsa.2012.2880
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =8800 mg/kg bw/day Rat oral: feed 91 days subchronic EFSA ANS - 2012 - OutputID 496 - no adverse effect observed at single/highest dose - Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive - doi:10.2903/j.efsa.2012.2880
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI <=7 mg/kg bw Consumers - - ADI EFSA CONTAM - 2012 - OutputID 2163 - Consumers - Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part III of III. - doi:10.2903/j.efsa.2012.2984
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI <=7 mg/kg bw Consumers - - ADI EFSA CONTAM - 2012 - OutputID 2163 - Consumers - Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part III of III. - doi:10.2903/j.efsa.2012.2984
ToxValDB_EFSA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =250 mg/kg bw/day Dog oral chronic; 28 weeks chronic LONG_REF=EFSA ANS (2012). Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive. doi:10.2903/j.efsa.2012.2880.; TITLE=Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2012.2880; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614337:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f34ec3caddfb5ba52345a63453dde653
ToxValDB_EFSA NOAEL =670 mg/kg bw/day Rat oral - reproduction developmental LONG_REF=EFSA ANS (2012). Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive. doi:10.2903/j.efsa.2012.2880.; TITLE=Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2012.2880; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614336:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8d1af853fc488fb31a60d8359ec0b100
ToxValDB_EFSA NOAEL =1500 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA ANS (2012). Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive. doi:10.2903/j.efsa.2012.2880.; TITLE=Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2012.2880; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614338:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_be507014f5f672edb974f927175f4ef3
ToxValDB_EFSA NOAEL =8800 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=EFSA ANS (2012). Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive. doi:10.2903/j.efsa.2012.2880.; TITLE=Scientific Opinion on the re-evaluation of carnauba wax (E 903) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2012.2880; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614339:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_366c3e78f6b53794ca315d588533272d
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=7 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afb94e4b0d99f5a87b366; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/939; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=WHO JECFA ADI:15715381:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7d9e6ed383a3e299682af28f8cc5ca35
openFDA substances 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier R12CBM0EIZ UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"R12CBM0EIZ"}
openFDA substances FDA UNII substance identifier R12CBM0EIZ UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"R12CBM0EIZ"}
openFDA substances FDA UNII substance identifier R12CBM0EIZ UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"R12CBM0EIZ"}
openFDA substances FDA UNII substance identifier R12CBM0EIZ UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"R12CBM0EIZ"}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}