NOAEL Studies Cosmetic Ingredient

Caprylyl Alcohol NOAEL Studies

INCI: CAPRYLYL ALCOHOL

CAS: 111-87-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 2564 mg/kg bw/day rat oral 90 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 650 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >3200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1080; row=11721; data_type=In Vivo; mixture=Chemical; chemical_name=1-Octanol; preferred_name=1-Octanol; dtxsid=DTXSID7021940; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021940; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1081; row=11722; data_type=In Vivo; mixture=Chemical; chemical_name=1-Octanol; preferred_name=1-Octanol; dtxsid=DTXSID7021940; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021940; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Fu 0.647 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2767; Record_ID=adme_parameters_2063; Data_Type=Measured; DTXSID=DTXSID7021940; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.647; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021940
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=1254; RecordID=ARPathway2016_582; DatasetName=ARPathway2016; DTXSID=DTXSID7021940; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021940
NTP_ICE_eye_irritation 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_eye_irritation Draize rabbit irritation score 41 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2028; Record_ID=eye_irritation_144; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7021940; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=41; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021940
NTP_ICE_eye_irritation GHS Classification 2 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2029; Record_ID=eye_irritation_144; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7021940; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021940
NTP_ICE_eye_irritation Intensity 0.16 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2034; Record_ID=eye_irritation_1286; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7021940; Assay=Vitrigel; Endpoint=Intensity; Response=0.16; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021940
NTP_ICE_eye_irritation Lag time 10 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2033; Record_ID=eye_irritation_1286; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7021940; Assay=Vitrigel; Endpoint=Lag time; Response=10; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021940
NTP_ICE_eye_irritation Plateau level 29 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2035; Record_ID=eye_irritation_1286; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7021940; Assay=Vitrigel; Endpoint=Plateau level; Response=29; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021940
NTP_ICE_skin_irritation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_irritation Positive reaction 17.9 % Human Dermal - In Vivo; Four-hour Human Patch Test sheet=Data_invivo; excel_row=1347; Record_ID=skin_irritation_invivo_56; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7021940; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=17.90; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021940
NTP_ICE_skin_irritation Positive reaction 16.4 % Human Dermal - In Vivo; Four-hour Human Patch Test sheet=Data_invivo; excel_row=1348; Record_ID=skin_irritation_invivo_57; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID7021940; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=16.40; Response_Unit=%; Species=Human; Reference=Robinson et al. 2001; 11422260; 10.1034/j.1600-0536.2001.045001001.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021940
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3732; Record_ID=skin_sensitization_invivo_925; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021940; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90067-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021940
NTP_ICE_skin_sensitization Induction dose per skin area 1296 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3730; Record_ID=skin_sensitization_invivo_925; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021940; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1296; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90067-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021940
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3736; Record_ID=skin_sensitization_invivo_925; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021940; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90067-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021940
ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =130 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bbad4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2096/7/9/3?documentUUID=e731448f-4c87-4e5e-aa4f-90b6daeffd79; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821958_15822186_15822674_15823035:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_93bb44590fac990770cda0d940356fe6
ToxValDB_ECHA_IUCLID NOAEC >400 mg/m3 Rat inhalation - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d18ae4b0a7c65d22f0b3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13265/7/9/3?documentUUID=171c170e-088c-4954-9f1c-ae8663447f79; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821206_15821247_15821495_15821533:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_47f66e8f52f602874834dcd353433244
ToxValDB_ECHA_IUCLID NOAEL ~210 mg/kg bw/day Mouse injection - chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d2179b3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2008/7/8?documentUUID=41ec3767-330f-4e0a-afb5-8f19d03196f3; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816230_15816628_15817990_15818434:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fed4b88d80a6745f221d9605c2e2ad45
ToxValDB_ECHA_IUCLID NOAEL =1300 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabc5e4b0a7c65d1bbad4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2096/7/9/3?documentUUID=e731448f-4c87-4e5e-aa4f-90b6daeffd79; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820600_15820848_15821361_15821746_15823417:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f75bd94e2784af4ce96f8292d2f2c070
ToxValDB_ECHA_IUCLID NOAEL =130 mg/kg bw/day Rat oral - short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d22040c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13265/7/6/2?documentUUID=171c170e-088c-4954-9f1c-ae8663447f79; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831945_15839276_15841461_15842920:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6b47f35f53849771329f0052679da657
ToxValDB_ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX NOEL =10 mmol/kg Rat oral short-term; 1.75 days short-term LONG_REF=Fundam. Appl. Toxicol.15(3): 429-440 Ray,S.D., and H.M. Mehendale Potentiation of CCL4 and CHCL3 Hepatotoxicity and Lethality by Various Alcohols 1990; TITLE=Potentiation of CCL4 and CHCL3 Hepatotoxicity and Lethality by Various Alcohols; AUTHOR=Ray,S.D., and H.M. Mehendale; DOI=10.1016/0272-0590(90)90029-j; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=78954; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Enzyme(s): Alanine transaminase (ALT)|Enzyme(s): Aspartate aminotransferase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15604187:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3e4f43b4bafef647c6ba432f1d39e9a7
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =106 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633889_15633890:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d9670e0f5017d668e473806e9a191f9d
ToxValDB_GESTIS_DNEL DNEL systemic =176 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633889_15633890:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_92132ca81a77b6c7b27ddedd4f5a089e
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier NV1779205D UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NV1779205D"}
openFDA substances FDA UNII substance identifier NV1779205D UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NV1779205D"}
openFDA substances FDA UNII substance identifier NV1779205D UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NV1779205D"}
openFDA substances FDA UNII substance identifier NV1779205D UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NV1779205D"}