NOAEL Studies Preservative

Caprylhydroxamic Acid NOAEL Studies

INCI: CAPRYLHYDROXAMIC ACID

CAS: 7377-03-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =10 % rat oral - developmental toxicity {"citation":"(10; 500; 50","dose":"The NOAEL of the test article (10% Caprylhydroxamic Acid in lactose) was determined to be 500 mg/kg bw/(corresponding to up to 50 mg/kg bw Caprylhydroxamic Acid).2 DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES Oral Groups of 18 mated female Wistar rats were dosed with 0, 50, 250, and 500 mg/kg bw/day 10% Caprylhydroxamic Acid (corresponding to 0, 5, 25,...","effect":"lanine aminotransferase activity and glucose and potassium levels in males, and there was a significant increase in leukocyte count and significant decreases in erythrocyte, hematocrit, and hemoglobin values in males and females. Spleen weights (absolute and relative to bw) were increased in males and females, and adrenal weights were significantly decreased in males. Slight atrophy in the epithelial cells of the renal glomeruli and hemosiderin deposits in the spleen were reported upon microscopic examination. The NOAEL of the test article (10% Caprylhydroxamic Acid in lactose) was determined to be 500 mg/kg bw/(corresponding to up to 50 mg/kg bw Caprylhydroxamic Acid).2 DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES Oral Groups of 18 mated female Wistar rats were dosed with 0, 50, 250, and 500 mg/kg bw/day 10% Caprylhydroxamic Acid (corresponding to 0, 5, 25, and 50 mg/kg bw Caprylhydroxamic Acid, respectively) by gavage on days 9 through 14 of gestation.2,27 The vehicle was 5% gum arabic solution. Twelve dams of the 0, 50, and 250 mg/kg bw/day groups, and all of the dams of the...","page":5,"pdf":"caphyd062020TR.pdf","row_type":"noael_study","study_id":"caphyd062020TR_noael_001"}
CIR Safety Assessment NOAEL =500 mg/kg bw/day rat oral 13-wk developmental toxicity {"citation":"1; 25; 2","dose":"In rats orally administered 1-[14C]-Caprylhydroxamic Acid, approximately 25% of the radioactivity was excreted as 14CO2 after 2 h, and by 24 h, 6.9% and 0.6% was excreted in the urine and the feces, respectively.","effect":"iver homogenates to caprylic acid and hydroxylamine. In rats orally administered 1-[14C]-Caprylhydroxamic Acid, approximately 25% of the radioactivity was excreted as 14CO2 after 2 h, and by 24 h, 6.9% and 0.6% was excreted in the urine and the feces, respectively. The oral LD50 of Caprylhydroxamic Acid is reported to be > 8820 mg/kg in rats. In a 13-wk study in which groups of 20 rats were dosed by gavage with up to 2500 mg/kg bw/day 10% Caprylhydroxamic Acid in lactose, with 5% aq. gum arabic as the vehicle, the NOAEL of the test article was determined to be 500 mg/kg bw/day (corresponding to up to 50 mg/kg bw Caprylhydroxamic Acid). Changes in some clinical chemistry parameters and organ weights (specifically an increase in absolute and relative spleen weight) were observed in the high dose group. A solution of Caprylhydroxamic Acid (10% in 5% gum arabic solution) was administered to groups of 18 mated rats, at doses up to 500 mg/kg bw/day, on days 9 – 14 of gestation. The majority of the dams were killed on day 20 of gestation; some were allowed to litter naturally. There was...","page":9,"pdf":"caphyd062020TR.pdf","row_type":"noael_study","study_id":"caphyd062020TR_noael_002"}
CIR Safety Assessment NOAEL =10 % rat oral - developmental toxicity {"citation":"(10; 500; 50","dose":"The NOAEL of the test article (10% Caprylhydroxamic Acid in lactose) was determined to be 500 mg/kg bw/(corresponding to up to 50 mg/kg bw Caprylhydroxamic Acid).2 DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES Oral Groups of 18 mated female Wistar rats were dosed with 0, 50, 250, and 500 mg/kg bw/day 10% Caprylhydroxamic Acid (corresponding to 0, 5, 25,...","effect":"lanine aminotransferase activity and glucose and potassium levels in males, and there was a significant increase in leukocyte count and significant decreases in erythrocyte, hematocrit, and hemoglobin values in males and females. Spleen weights (absolute and relative to bw) were increased in males and females, and adrenal weights were significantly decreased in males. Slight atrophy in the epithelial cells of the renal glomeruli and hemosiderin deposits in the spleen were reported upon microscopic examination. The NOAEL of the test article (10% Caprylhydroxamic Acid in lactose) was determined to be 500 mg/kg bw/(corresponding to up to 50 mg/kg bw Caprylhydroxamic Acid).2 DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES Oral Groups of 18 mated female Wistar rats were dosed with 0, 50, 250, and 500 mg/kg bw/day 10% Caprylhydroxamic Acid (corresponding to 0, 5, 25, and 50 mg/kg bw Caprylhydroxamic Acid, respectively) by gavage on days 9 through 14 of gestation.2,27 The vehicle was 5% gum arabic solution. Twelve dams of the 0, 50, and 250 mg/kg bw/day groups, and all of the dams of the...","page":5,"pdf":"caphyd062020TR.pdf","row_type":"noael_study","study_id":"caphyd062020TR_noael_001"}
CIR Safety Assessment NOAEL =500 mg/kg bw/day rat oral 13-wk developmental toxicity {"citation":"1; 25; 2","dose":"In rats orally administered 1-[14C]-Caprylhydroxamic Acid, approximately 25% of the radioactivity was excreted as 14CO2 after 2 h, and by 24 h, 6.9% and 0.6% was excreted in the urine and the feces, respectively.","effect":"iver homogenates to caprylic acid and hydroxylamine. In rats orally administered 1-[14C]-Caprylhydroxamic Acid, approximately 25% of the radioactivity was excreted as 14CO2 after 2 h, and by 24 h, 6.9% and 0.6% was excreted in the urine and the feces, respectively. The oral LD50 of Caprylhydroxamic Acid is reported to be > 8820 mg/kg in rats. In a 13-wk study in which groups of 20 rats were dosed by gavage with up to 2500 mg/kg bw/day 10% Caprylhydroxamic Acid in lactose, with 5% aq. gum arabic as the vehicle, the NOAEL of the test article was determined to be 500 mg/kg bw/day (corresponding to up to 50 mg/kg bw Caprylhydroxamic Acid). Changes in some clinical chemistry parameters and organ weights (specifically an increase in absolute and relative spleen weight) were observed in the high dose group. A solution of Caprylhydroxamic Acid (10% in 5% gum arabic solution) was administered to groups of 18 mated rats, at doses up to 500 mg/kg bw/day, on days 9 – 14 of gestation. The majority of the dams were killed on day 20 of gestation; some were allowed to litter naturally. There was...","page":9,"pdf":"caphyd062020TR.pdf","row_type":"noael_study","study_id":"caphyd062020TR_noael_002"}
CIR Safety Assessment NOAEL =10 % rat oral - developmental toxicity {"citation":"(10; 500; 50","dose":"The NOAEL of the test article (10% Caprylhydroxamic Acid in lactose) was determined to be 500 mg/kg bw/(corresponding to up to 50 mg/kg bw Caprylhydroxamic Acid).2 DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES Oral Groups of 18 mated female Wistar rats were dosed with 0, 50, 250, and 500 mg/kg bw/day 10% Caprylhydroxamic Acid (corresponding to 0, 5, 25,...","effect":"lanine aminotransferase activity and glucose and potassium levels in males, and there was a significant increase in leukocyte count and significant decreases in erythrocyte, hematocrit, and hemoglobin values in males and females. Spleen weights (absolute and relative to bw) were increased in males and females, and adrenal weights were significantly decreased in males. Slight atrophy in the epithelial cells of the renal glomeruli and hemosiderin deposits in the spleen were reported upon microscopic examination. The NOAEL of the test article (10% Caprylhydroxamic Acid in lactose) was determined to be 500 mg/kg bw/(corresponding to up to 50 mg/kg bw Caprylhydroxamic Acid).2 DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES Oral Groups of 18 mated female Wistar rats were dosed with 0, 50, 250, and 500 mg/kg bw/day 10% Caprylhydroxamic Acid (corresponding to 0, 5, 25, and 50 mg/kg bw Caprylhydroxamic Acid, respectively) by gavage on days 9 through 14 of gestation.2,27 The vehicle was 5% gum arabic solution. Twelve dams of the 0, 50, and 250 mg/kg bw/day groups, and all of the dams of the...","page":5,"pdf":"caphyd062020TR.pdf","row_type":"noael_study","study_id":"caphyd062020TR_noael_001"}
CIR Safety Assessment NOAEL =500 mg/kg bw/day rat oral 13-wk developmental toxicity {"citation":"1; 25; 2","dose":"In rats orally administered 1-[14C]-Caprylhydroxamic Acid, approximately 25% of the radioactivity was excreted as 14CO2 after 2 h, and by 24 h, 6.9% and 0.6% was excreted in the urine and the feces, respectively.","effect":"iver homogenates to caprylic acid and hydroxylamine. In rats orally administered 1-[14C]-Caprylhydroxamic Acid, approximately 25% of the radioactivity was excreted as 14CO2 after 2 h, and by 24 h, 6.9% and 0.6% was excreted in the urine and the feces, respectively. The oral LD50 of Caprylhydroxamic Acid is reported to be > 8820 mg/kg in rats. In a 13-wk study in which groups of 20 rats were dosed by gavage with up to 2500 mg/kg bw/day 10% Caprylhydroxamic Acid in lactose, with 5% aq. gum arabic as the vehicle, the NOAEL of the test article was determined to be 500 mg/kg bw/day (corresponding to up to 50 mg/kg bw Caprylhydroxamic Acid). Changes in some clinical chemistry parameters and organ weights (specifically an increase in absolute and relative spleen weight) were observed in the high dose group. A solution of Caprylhydroxamic Acid (10% in 5% gum arabic solution) was administered to groups of 18 mated rats, at doses up to 500 mg/kg bw/day, on days 9 – 14 of gestation. The majority of the dams were killed on day 20 of gestation; some were allowed to litter naturally. There was...","page":9,"pdf":"caphyd062020TR.pdf","row_type":"noael_study","study_id":"caphyd062020TR_noael_002"}
CIR Safety Assessment NOAEL =10 % rat oral - developmental toxicity {"citation":"(10; 500; 50","dose":"The NOAEL of the test article (10% Caprylhydroxamic Acid in lactose) was determined to be 500 mg/kg bw/(corresponding to up to 50 mg/kg bw Caprylhydroxamic Acid).2 DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES Oral Groups of 18 mated female Wistar rats were dosed with 0, 50, 250, and 500 mg/kg bw/day 10% Caprylhydroxamic Acid (corresponding to 0, 5, 25,...","effect":"lanine aminotransferase activity and glucose and potassium levels in males, and there was a significant increase in leukocyte count and significant decreases in erythrocyte, hematocrit, and hemoglobin values in males and females. Spleen weights (absolute and relative to bw) were increased in males and females, and adrenal weights were significantly decreased in males. Slight atrophy in the epithelial cells of the renal glomeruli and hemosiderin deposits in the spleen were reported upon microscopic examination. The NOAEL of the test article (10% Caprylhydroxamic Acid in lactose) was determined to be 500 mg/kg bw/(corresponding to up to 50 mg/kg bw Caprylhydroxamic Acid).2 DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES Oral Groups of 18 mated female Wistar rats were dosed with 0, 50, 250, and 500 mg/kg bw/day 10% Caprylhydroxamic Acid (corresponding to 0, 5, 25, and 50 mg/kg bw Caprylhydroxamic Acid, respectively) by gavage on days 9 through 14 of gestation.2,27 The vehicle was 5% gum arabic solution. Twelve dams of the 0, 50, and 250 mg/kg bw/day groups, and all of the dams of the...","page":5,"pdf":"caphyd062020TR.pdf","row_type":"noael_study","study_id":"caphyd062020TR_noael_001"}
CIR Safety Assessment NOAEL =500 mg/kg bw/day rat oral 13-wk developmental toxicity {"citation":"1; 25; 2","dose":"In rats orally administered 1-[14C]-Caprylhydroxamic Acid, approximately 25% of the radioactivity was excreted as 14CO2 after 2 h, and by 24 h, 6.9% and 0.6% was excreted in the urine and the feces, respectively.","effect":"iver homogenates to caprylic acid and hydroxylamine. In rats orally administered 1-[14C]-Caprylhydroxamic Acid, approximately 25% of the radioactivity was excreted as 14CO2 after 2 h, and by 24 h, 6.9% and 0.6% was excreted in the urine and the feces, respectively. The oral LD50 of Caprylhydroxamic Acid is reported to be > 8820 mg/kg in rats. In a 13-wk study in which groups of 20 rats were dosed by gavage with up to 2500 mg/kg bw/day 10% Caprylhydroxamic Acid in lactose, with 5% aq. gum arabic as the vehicle, the NOAEL of the test article was determined to be 500 mg/kg bw/day (corresponding to up to 50 mg/kg bw Caprylhydroxamic Acid). Changes in some clinical chemistry parameters and organ weights (specifically an increase in absolute and relative spleen weight) were observed in the high dose group. A solution of Caprylhydroxamic Acid (10% in 5% gum arabic solution) was administered to groups of 18 mated rats, at doses up to 500 mg/kg bw/day, on days 9 – 14 of gestation. The majority of the dams were killed on day 20 of gestation; some were allowed to litter naturally. There was...","page":9,"pdf":"caphyd062020TR.pdf","row_type":"noael_study","study_id":"caphyd062020TR_noael_002"}
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =10700 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_9840; row=14702; data_type=In Vivo; mixture=Chemical; chemical_name=Octanamide, N-hydroxy-; preferred_name=Octanamide, N-hydroxy-; dtxsid=DTXSID8074609; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8074609; source_file=acute_oral.xlsx
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier UPY805K99W UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H17NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UPY805K99W"}
openFDA substances FDA UNII substance identifier UPY805K99W UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H17NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UPY805K99W"}
openFDA substances FDA UNII substance identifier UPY805K99W UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H17NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UPY805K99W"}
openFDA substances FDA UNII substance identifier UPY805K99W UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H17NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UPY805K99W"}