NOAEL Studies Active Ingredient

Camphor NOAEL Studies

INCI: CAMPHOR

CAS: 76-22-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 800 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 0.5 mg/L - Inhalation - In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=3008; Record_ID=acute_inhalation_3569; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5030955; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.5; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5030955; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5030955
ECHA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL =400 mg/kg bw/day Mouse dermal - subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d6fe4b096bca8775c83; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24627/7/6/4?documentUUID=e38159ef-7bb1-4f5c-967c-3c5e0e2f6429; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826181_15826182:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_71a7a54989b4f5c2eb26c87ed5115bb8
ECHA NOAEL =1000 mg/kg bw/day Mouse dermal - subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d6fe4b096bca8775c83; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24627/7/6/4?documentUUID=e38159ef-7bb1-4f5c-967c-3c5e0e2f6429; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826181_15826182:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c1f7a84231b7b8884e4600c7372ab338
ECHA NOAEL =250 mg/kg bw/day Rat dermal - subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f5ee4b096bca877d446; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24627/7/6/4?documentUUID=e38159ef-7bb1-4f5c-967c-3c5e0e2f6429; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15826835:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dc8f17c1bd87b2bd252a3d2cc4b3dbd9
ECHA NOAEL =6000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab95e4b0a7c65d1baf0d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13464/7/9/2?documentUUID=341f03c9-2697-4a75-b830-b55fb7de2def; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=P0: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15860908:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ffeb9835058066acdab4c4924f53e3da
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =17.632 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630567:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bb96c990f0320b599c22018b3ed78631
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 5TJD82A1ET UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H16O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5TJD82A1ET"}
openFDA substances FDA UNII substance identifier 5TJD82A1ET UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H16O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5TJD82A1ET"}
openFDA substances FDA UNII substance identifier 5TJD82A1ET UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H16O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5TJD82A1ET"}
openFDA substances FDA UNII substance identifier 5TJD82A1ET UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H16O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5TJD82A1ET"}